Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy

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康复运动操联合牵引在老年腰椎间盘突出症患者中的应用效果研究

目的探讨康复运动操联合牵引在老年腰椎间盘突出症患者中的应用效果及对腰椎活动度的影响。 方法选择2018年10月至2019年9月老年腰椎间盘突出症患者86例作为对象，随机分为对照组（n=43例）和观察组（n=43例）。对照组采用常规牵引治疗，观察组在对照组基础上联合康复运动操治疗，4周治疗后对患者效果进行评估，比较两组视觉模拟疼痛（VAS）评分、炎症因子水平、腰椎活动度及满意度。 结果观察组治疗后1、2、3、4周VAS评分低于对照组（P<0.05）；观察组治疗后4周IL-1β、TNF-α及TXB2水平均低于对照组（P<0.05）；观察组治疗后4周前屈、后伸、侧屈均高于对照组（P<0.05）；观察组治疗后4周遵医治疗、康复运动、定期复查、治疗效果及治疗形式满意度均高于对照组（P<0.05）。 结论康复运动操联合牵引能减轻老年腰椎间盘突出症患者疼痛，提高患者腰椎活动度，且两种方法干预能降低机体炎症瀑布联级反应，提高患者治疗满意度，值得推广应用。     

Effects of Ginkgo biloba extract EGb761 on neural differentiation of stem cells offer new hope for neurological disease treatment

Stem cell transplantation has brought new hope for the treatment of neurological diseases.The key to stem cell therapy lies in inducing the specific differentiation of stem cells into nerve cells.Because the differentiation of stem cells in vitro and in vivo is affected by multiple factors,the final differentiation outcome is strongly associated with the microenvironment in which the stem cells are located.Accordingly,the optimal microenvironment for inducing stem cell differentiation is a hot topic.EGb761 is extracted from the leaves of the Ginkgo biloba tree.It is used worldwide and is becoming one of the focuses of stem cell research.Studies have shown that EGb761 can antagonize oxygen free radicals,stabilize cell membranes,promote neurogenesis and synaptogenesis,increase the level of brain-derived neurotrophic factors,and replicate the environment required during the differentiation of stem cells into nerve cells.This offers the possibility of using EGb761 to induce the differentiation of stem cells,facilitating stem cell transplantation.To provide a comprehensive reference for the future application of EGb761 in stem cell therapy,we reviewed studies investigating the influence of EGb761 on stem cells.These started with the composition and neuropharmacology of EGb761,and eventually led to the finding that EGb761 and some of its important components play important roles in the differentiation of stem cells and the protection of a beneficial microenvironment for stem cell transplantation.     

案例式立体教学法在腹部提压心肺复苏培训中的应用研究

目的探讨案例式立体教学法在腹部提压心肺复苏培训中的应用效果。 方法选取2018年在南方医科大学附属郑州人民医院进行全科医师规范化培训的60名学员为研究对象，根据学员工号，采用数字奇偶法将其分为实验组和对照组，每组30名。实验组学员采用案例式立体教学法，对照组学员采用传统教学方法，培训结束后采用考核和问卷调查的方法对教学效果进行评估分析。 结果实验组学员理论成绩为(89.83±5.33)分，对照组学员理论成绩为(86.17±6.52)分，差异有统计学意义(P<0.05)。实验组学员技能成绩为(84.17±5.43)分，对照组学员技能成绩为(78.50±5.44)分，差异有统计学意义(P<0.05)。问卷调查结果显示，案例式立体教学法在增强学习兴趣、提高思维能力、深化学习印象、增强思考主动性、强化理论与临床桥接方面的满意度均优于传统教学法，差异均有统计学意义(均P<0.05)。 结论案例式立体教学法应用于全科医师的腹部提压心肺复苏培训，有利于提高学员理论成绩和技能成绩，有利于提高思维能力、增强思考主动性、增加学习兴趣、深化学习印象和强化理论与临床桥接。     

肠旋转不良型左侧阑尾炎腹腔镜切除一例

正患者女,40岁,身高160 cm,体质量52 kg,因2 d前无明显诱因出现左下腹部持续性绞痛,于2018年10月19日急诊入院,体温37.7℃,脉搏112次/分,伴稍恶心,无呕吐、放射痛、发热,无腹泻、血便,无尿频、尿痛等症状。1 d前曾在当地社区医院以"急性肠炎"给予抗感染、解痉等治疗,自觉症状有所缓解,次日午间症状再次加重。查体:左下腹压痛(+)、反跳痛(+),局部腹肌紧张明显。行腹部CT平扫检查示:结肠走行反位,右半结肠位于左上腹,阑尾增粗伴周围渗出,周围间隙模糊,阑尾最粗约1.7 cm,临近盲肠壁稍增厚;胃腔大部分位于右侧,十二指肠垂直下行,可见Ladd束带;肝脏体积明显增大;脾脏受推挤,位于左侧肾上腺前方(图1～3)。诊     

布地奈德联合特布他林对慢性阻塞性肺疾病患者肺功能的影响

目的:探究布地奈德与特布他林联合应用于慢性阻塞性肺疾病(COPD)患者中的治疗效果,并探究其对患者肺功能的影响。方法:选取某院2018年4月~2019年3月收治的COPD患者(n=82例)为实验对象,依据不同的治疗方法,将入选患者分为联合组及单一组,每组41例,其中单一组采用特布他林治疗,联合组采用特布他林联合布地奈德治疗。观察两组患者的治疗效果、不良反应及其治疗前后的肺功能改善情况。结果:联合组的治疗总有效率为95.12%,与单一组的75.61%比较,两者差异显著(χ^2=6.248,P<0.05)。联合组治疗后FEV1为(2.46±0.97)L,显著高于单一组[(1.35±0.32)L,P<0.05];FVC为(2.84±0.66)L,显著高于单一组[(2.26±0.15)L,P<0.05];FEV1/FVC为(65.51±8.96),显著高于单一组[(58.31±7.93),P<0.05]。联合组的总不良反应率为7.32%,低于单一组的12.20%,但差异不显著(χ^2=0.554,P>0.05)。结论:布地奈德结合特布他林治疗COPD具有较好的治疗效果,可显著改善患者的肺功能,减少不良反应,安全性高。     

Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING

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Exercise training‐induced visceral fat loss in obese women: The role of training intensity and modality

Visceral fat loss in response to four‐cycle ergometer training regimens with explicit differences in exercise intensity and modality was compared. Fifty‐nine obese young women (body fat percentage ≥ 30%) were randomized to a 12‐week intervention consisting of either all‐out sprint interval training (SIT_all‐out, n = 11); supramaximal SIT (SIT₁₂₀, 120% O_2peak, n = 12); high‐intensity interval training (HIIT₉₀, 90% O_2peak, n = 12), moderate‐intensity continuous training (MICT, 60% O_2peak, n = 11), or no training (CON, n = 13). The total work done per training session in SIT₁₂₀, HIIT₉₀, and MICT was confined to 200 kJ, while it was deliberately lower in SIT_all‐out. The abdominal visceral fat area (AVFA) was measured through computed tomography scans. The whole‐body and regional fat mass were assessed through dual‐energy X‐ray absorptiometry. Pre‐, post‐, and 3‐hour post‐exercise serum growth hormone (GH), and epinephrine (EPI) were measured during selected training sessions. Following the intervention, similar reductions in whole‐body and regional fat mass were found in all intervention groups, while the reductions in AVFA resulting from SIT_all‐out, SIT₁₂₀, and HIIT₉₀ (>15 cm²) were greater in comparison with MICT (<3.5 cm², P < .05). The AVFA reductions among the SITs and HIIT groups were similar, and it was concomitant with the similar exercise‐induced releases of serum GH and EPI. CON variables were unchanged. These findings suggest that visceral fat loss induced by interval training at or above 90% O_2peak appeared unresponsive to the change in training intensity. Nonetheless, SIT_all‐out is still the most time‐efficient strategy among the four exercise‐training regimes for controlling visceral obesity.