Clinical Diagnostic Implications of Body Fluid MiRNA in Oral Squamous Cell Carcinoma: A Meta-Analysis

Oral cancer, predominantly oral squamous cell carcinoma (OSCC), is one of the most leading causes of cancers worldwide. Due to a low 5-year survival rate, highly effective methods for the early detection of OSCC are totally needed. MicroRNAs (miRNAs), as promising biomarkers, can bring insights into tumorigenesis of oral cancers. However, studies on the accuracy of miRNAs detection in OSCC have inconsistent conclusions, leading us to conduct this meta-analysis. The aim of this study was to systematically review the articles investigating the diagnostic value of miRNAs in OSCC.The PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), Web of Science were searched (updated to June 11th, 2015) to identify all articles evaluating the diagnostic yield of miRNAs for OSCC. The pooled sensitivity, specificity, and other diagnostic parameters were used to assess the performance of miRNAs assays on OSCC detection. Statistical analysis was conducted by employing the R software.The present meta-analysis comprised 23 studies from 10 articles, including 598 OSCC patients and 320 healthy individuals, available for analysis. The summary receiver operator characteristic (SROC) curve was plotted. Meanwhile, the pooled diagnostic parameters and the area under curve (AUC) were calculated based on all included studies. The pooled diagnostic parameters calculated from all 23 studies were as follows: pooled sensitivity of 0.759 (95% CI: 0.701–0.809), pooled specificity of 0.773 (95% CI: 0.713–0.823) and AUC of 0.832, which indicates a relatively high diagnostic accuracy of miRNAs in differentiating OSCC patients from healthy controls. Meanwhile, In addition, subgroup analyses were conducted to access the heterogeneity between studies, which is based on specimen (serum/plasma/blood/saliva/ tissue) and ethnicity (Asian/Caucasian).In summary, our meta-analysis suggests that miRNAs might be used in noninvasive screening tests for OSCC, which needs further large-scale studies to be validated.     

深圳市制造企业90后新招产线员工心理弹性、应对方式与心理健康间的关系

目的探讨深圳市3家制造企业新招90后产线员工心理弹性、应对方式和心理健康间是否存在某种关系。方法在深圳市3家制造企业选取入职一周的新招90后产线员工,以其入职日期为单位进行整群抽样。应用心理弹性量表CDRISC、简易应对方式问卷SCSQ以及一般健康问卷GHQ-20三个量表分别测量其心理弹性、应对方式以及心理健康,并利用结构方程模型软件Amos 17.0进行路径分析。结果心理弹性与心理健康呈正相关关系(P<0.01);心理弹性和心理健康与积极应对呈正相关关系(P<0.01);心理弹性和心理健康与消极应对呈负相关关系(P<0.01);结构方程模型结果表明:心理弹性既可以直接影响心理健康,又可以通过积极应对和消极应对的中介作用间接影响心理健康。结论深圳市制造企业新招产线员工的心理弹性、应对方式与心理健康间存在线性相关关系,且心理弹性通过积极应对和消极应对对心理健康起着部分间接的作用。     

Treatment of An Acute Severe Cadmium Poisoning Patient Combined with Multiple Organ Dysfunction Syndromes by Integrated Chinese and Western Medicines: A Case Report

正Cadmium(Cd), a toxic heavy metal commonly found in the environment, can cause toxic reactions at a dose of 30 mg. Cd is absorbed into the body mainly through the respiratory tract, digestive tract,     

难治性胃食管反流病临证研究

难治性胃食管反流病是临床疑难病,症状反复,缠绵难愈,治疗棘手。中医药治疗“反酸”“吞酸”证历久源远,充分挖掘古籍,深研病机,提炼治法,发挥中医药特色,对治疗本病意义深远。     

小汤山地区0-3岁儿童喂养情况及母亲孕期贫血情况与贫血的关系

目的了解北京市小汤山地区儿童贫血分布情况,并指出合理化预防措施。方法采用日本产西斯美康xs-800i全血细胞分析仪,检测0-3岁儿童末梢血的血红蛋白含量。结果 2013年儿保门诊0~3岁儿童体检人数为1334人,其中贫血患儿为176名,贫血的发病率是13.19%。其中,本地儿童616人,贫血发病率是9.42%;流动儿童718人,贫血发病率是16.43%,二者间有统计学差异(P0.01);男性儿童贫血发病率为13.02%,女性贫血发病率13.46%,二者间无统计学差异(P0.01);6个月-1岁儿童贫血发病率为35.79%,1-2岁为4.48%,2-3岁为2.61%,三组间有统计学差异(P0.01),纯母乳喂养儿童贫血人数为47人,贫血的发病率是6.15%,混合喂养儿童贫血人数为29人,贫血的发病率是8.19%,人工喂养喂养儿童贫血人数为100人,贫血的发病率是46.30%,三者差异存在统计学意义(P0.01);母孕期贫血儿童贫血人数为97人,贫血的发病率是18.29%,母孕期无贫血儿童贫血人数为79人,贫血的发病率是10.75%,三者差异存在统计学意义(P0.01)。结论本地区0~3岁儿童贫血患病比6个月-1岁儿童显著增高,流动儿童比本市儿童贫血患病率显著增高,此外母孕期贫血及婴儿喂养方式的不同也是影响儿童贫血的原因,加强流动儿童管理,正确指导6个月后婴儿家长的喂养方法及加强预产妇孕期营养指导应成为今后工作的重点。