全文获取类型
收费全文 | 7394篇 |
免费 | 473篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 43篇 |
儿科学 | 224篇 |
妇产科学 | 81篇 |
基础医学 | 1028篇 |
口腔科学 | 149篇 |
临床医学 | 531篇 |
内科学 | 1884篇 |
皮肤病学 | 253篇 |
神经病学 | 627篇 |
特种医学 | 271篇 |
外科学 | 824篇 |
综合类 | 38篇 |
一般理论 | 1篇 |
预防医学 | 376篇 |
眼科学 | 170篇 |
药学 | 549篇 |
中国医学 | 16篇 |
肿瘤学 | 839篇 |
出版年
2024年 | 4篇 |
2023年 | 75篇 |
2022年 | 126篇 |
2021年 | 235篇 |
2020年 | 145篇 |
2019年 | 179篇 |
2018年 | 238篇 |
2017年 | 188篇 |
2016年 | 236篇 |
2015年 | 239篇 |
2014年 | 329篇 |
2013年 | 384篇 |
2012年 | 568篇 |
2011年 | 600篇 |
2010年 | 327篇 |
2009年 | 286篇 |
2008年 | 516篇 |
2007年 | 543篇 |
2006年 | 417篇 |
2005年 | 428篇 |
2004年 | 437篇 |
2003年 | 378篇 |
2002年 | 391篇 |
2001年 | 56篇 |
2000年 | 54篇 |
1999年 | 55篇 |
1998年 | 82篇 |
1997年 | 60篇 |
1996年 | 59篇 |
1995年 | 27篇 |
1994年 | 33篇 |
1993年 | 31篇 |
1992年 | 28篇 |
1991年 | 17篇 |
1990年 | 25篇 |
1989年 | 12篇 |
1988年 | 13篇 |
1987年 | 14篇 |
1986年 | 11篇 |
1985年 | 8篇 |
1984年 | 11篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1973年 | 2篇 |
1970年 | 5篇 |
排序方式: 共有7904条查询结果,搜索用时 15 毫秒
11.
The sentinel node (SN) concept was originally proposed by several pioneers in the middle of the last century. After Donald Morton and his colleagues demonstrated the clinical significance of the SN concept in melanoma, it attracted vast attention in surgical oncology. At recent international conferences, a number of new approaches in this field for various solid tumors have been reported. Now, there are several possible applications with different technological aspects, such as individualized surgical management of solid tumors, multidisciplinary treatments, and novel therapeutic approaches. This article provides an overview of the future potential of SN technology. 相似文献
12.
Masashi Kato Shinji Sato Misako Suzuki Hiroko Oka Yuko Kaneko Hidekata Yasuoka Takaki Nojima Akira Suwa Michito Hirakata Yasuo Ikeda 《Nihon Rinshō Men'eki Gakkai kaishi》2004,27(5):345-349
A 52 year-old woman noticed general fatigue, polyarthralgia, and muscle weakness of lower extremities in October 2001. In December, she felt difficulty in walking due to muscle weakness. In January 2002, she admitted another hospital because of dyspnea on exertion and edema of lower extremities. Laboratory test revealed leukocytopenia, the elevation of creatine kinase and positive anti-U1-RNP antibodies. Her chest computed tomography (CT) showed severe interstitial pneumonia. Cardiac echogram revealed that she had pericardial effusion and pulmonary hypertension. Then she was transferred to Keio University Hospital and she was diagnosed as having mixed connective tissue disease (MCTD) manifestating myositis, interstitial pneumonia, pulmonary hypertension and pericarditis. Prednisolone (PSL) 60mg daily following to methylprednisolone (mPSL) pulse therapy was begun and her symptoms were gradually improved. In middle of February, she complained of high fever over 39.0 degrees C. Bacterial culture tests were negative and laboratory data indicated pancytopenia and a high level of serum ferritin. Bone marrow aspiration revealed hemophagocytosis in bone marrow specimens and she was diagnosed as having hemophagocytic syndrome associated with MCTD. mPSL pulse therapy was not effective and intermittent cyclophosphamide pulse therapy (IV-CY) was performed resulting in improvement of the symptoms. This case suggested the effectiveness of IV-CY therapy in patients with corticosteroid-resistant HPS associated with connective tissue diseases. 相似文献
13.
Mayumi Matsuta Yuko Imamura Morimasa Matsuta Saiichi Kon Kohsuke Sasaki 《The Journal of dermatology》1994,21(1):14-19
We have applied DNA flow cytometric analysis to paraffin-embedded tissue sections of primary malignant melanomas. Conventionally, flow cytometric analysis of paraffin-embedded tissue sections has been done by the method of Hedley et al. We added ultrasound treatment to the method of Hedley et al. and a lower value of coefficient of variation was shown. Furthermore, a new technique, fluorescence in situ hybridization with a chromosome-specific repetitive DNA probe, was used for the analysis of chromosomal numerical aberrations in the same paraffin-embedded tissue sections. The DNA flow cytometric analysis showed that in 8 cases six primary malignant melanomas were of the aneuploid pattern and two cases of lentigo maligna (melamona in situ) were of the diploid pattern. By fluorescence in situ hybridization, the two cases with the diploid pattern had spots/nucleus of 1.28 and 1.12, and those with the aneuploid pattern had spots/nucleus from 2.01 to 2.27. Only one nodular melanoma in an aneuploid case showed spots/nucleus of 1.71. These data indicate that fluorescence in situ hybridization with chromosome-specific repetitive DNA probes can serve as a cytogenetic tool for the analysis of interphase nuclei of solid human tumors and may be useful for the study of tumor cell heterogeneity. 相似文献
14.
15.
Progressive multifocal leukoencephalopathy (PML) is caused by opportunistic infection of JC virus which belongs to Papovavirus, and presents with progressive demyelinating lesion in the central nervous system. PML was originally reported as a rare complication of hematologic disorders, but later greatly increased in number in association with acquired immunodeficeincy syndrome (AIDS). Original neuropathological features of PML consist of demyelination lacking inflammatory reaction or necrosis, accompanying oligodendroglial nuclear inclusions in the periphery of demyelination. The lesion is preferentially localized to gray-white junction of the cerebral hemisphere and manifests as characteristic demyelinating lesion, called scallopping. Detection of JC virus is essential for the final diagnosis of PML and is achieved via immunohistochemical detection of JC virus with antibodies raised against their components, ultrastructural demonstration of virions characteristic of JC virus, or detection with in-situ hybridization of the genome of JC virus. JC virus can replicate only in oligodendroglial cells, but astrocytes are frequently infected by the virus. The resume of immunological function through therapeutic intervention develops new pathology in PML, exhibiting severe inflammatory reaction with edema and necrosis. This new pathological feature is called immune reconstruction syndrome and clinically presents with severe progression in symptoms of the central nervous system. Nevertheless, treatment of PML is directed for the elimination of the viruses by host immune system. The modification of the above immune reconstruction syndrome is essential for successful outcome of such therapeutic trial. 相似文献
16.
Movement of the lateral and medial poles of the working condyle during mastication in patients with unilateral posterior crossbite. 总被引:1,自引:0,他引:1
Shouichi Miyawaki Yuko Tanimoto Yoshiko Araki Akira Katayama Takuo Kuboki Teruko Takano-Yamamoto 《American journal of orthodontics and dentofacial orthopedics》2004,126(5):549-554
Patients with unilateral posterior crossbite often show reverse sequential jaw movement patterns on the frontal view during mastication on the crossbite side. Recent studies show that such patients are prone to suffer from temporomandibular joint (TMJ) disc displacement, particularly the lateral portion. The purpose of this study was to examine the movement of the lateral and medial poles of the working condyle during mastication in such patients. Subjects were 12 consecutive patients with unilateral posterior crossbites and without TMJ disc displacements and 12 normal subjects. An optoelectronic jaw-tracking system with 6 degrees of freedom was used to record the motion of the lateral and medial poles of the working condyle during mastication of standardized hard, gummy jelly. The data from the first 10 cycles were analyzed. The lateral and medial poles of the condyle on the crossbite side moved more in the medial direction and less in the lateral direction during mastication in the crossbite patients than the condyle in the normal subjects. The lateral pole of the working condyle moved more in the posterior and inferior directions and less in the anterior direction than the medial pole in all subjects. These results suggest that these condylar movements in patients with unilateral posterior crossbites might be related to the susceptibility to TMJ disc displacement, particularly the lateral portion. 相似文献
17.
Conclusions Reduced utilization of fatty acids at rest often is observed in severely ischemic myocardium and possibly postischemic myocardium
despite normal perfusion at rest. The role of metabolic imaging in identifying postischemic insult as ischemic memory imaging
has been the focus of recent investigations. A number of reports from Japan show quite acceptable diagnostic accuracy of BMIPP
imaging for detecting coronary patients without prior MI. In addition, recent data indicate that BMIPP imaging has prognostic
value when applied in patients with documented or suspected coronary disease. The major advantage of BMIPP imaging is to demonstrate
ischemic myocardium as an area of altered metabolism at rest. Thus this study is of clinical importance for elderly patients
or for patients not suitable for a stress study. Furthermore, this radiopharmaceutical tracer may hold promise in demonstrating
early alteration of energy metabolism in a variety of myocardial disorders. 相似文献
18.
19.
Yasuaki Antoku Eisuke Hanada Kouhei Akazawa Yuko Kenjo Yoshiaki Nose 《Journal of medical systems》1997,21(4):211-218
SOHO (Small Office/Home Office) has recently become popular, as it makes working at home possible. Computers or Local Area Networks(LAN) connected to the office network from home are necessary for the implementation of this concept. Kyushu University has begun a service connecting home computers to the campus LAN for researchers, staff and students of the Faculty of Medicine. We have two different telephone connection methods. One connects the campus LAN and the home computer LAN using routers through the Integrated Services Digital Network (ISDN). The other connects computers at home to the workstation in the university, using modems and the PPP (Point to Point Protocol) through a public telephone analog line. This paper outlines our university SOHO connection system and discusses the merits and demerits of using telephone line connections. 相似文献
20.
Toshimichi Hasegawa Yuko Tazuke Yasuhiro Iwasaki Osamu Monta Junichi Sumimura Hiroshi Koyama Toru Dezawa 《Surgery today》1997,27(12):1191-1194
We report herein the case of a premature infant with esophageal atresia (EA) and a tracheoesophageal fistula (TEF) associated
with cardiac anomalies who was successfully treated by an early ligation of the TEF following gastrostomy, and delayed repair
of the esophagus. A 1212-g male was born prematurely at 31 gestational weeks, at which time he was diagnosed as having EA
with TEF and patent ductus arteriosus (PDA), ventricular septal defect (VSD), and atrial septal defect (ASD). A gastrostomy
was initially performed but following extubation he gradually became tachypneic. A chest roentogenogram revealed atelectasis
and ground-glass appearance, and reintubation was required. Ligation of the TEF was performed 53h after his birth. Following
the improvement of his respiratory condition through ventilatory support and the intratracheal administration of pulmonary
surfactant, he underwent repair of the esophagus on the 6th day of life. Postoperatively, he suffered from heart failure,
but was treated with peritoneal dialysis and pharmacological closure of the PDA. Weaning the infant from the ventilator proved
difficult, but it was finally achieved when he had reached a weight of 2268g at 3 months of age by enteral feeding. Our experience
of this case demonstrates that early ligation of TEF should be performed for a premature infant with EA and TEF before respiratory
distress syndrome (RDS) has developed. If a gastrostomy is required to prevent gastric distention, it should be followed by
simultaneous or immediate ligation of the TEF. 相似文献