深圳市南山区8～24月龄儿童基础免疫延迟接种影响因素的调查分析

采用按容量比例概率抽样法（PPS）随机抽取深圳市南山区30个居委会的210名8～24mon龄儿童,以被抽中儿童及其父母作为调查对象,对他们进行问卷调查。调查内容包括：儿童、父母一般情况,父母有关计划免疫知识和健康信念,计划免疫服务评价,儿童计划免疫情况等。对其中的184份有效问卷进行了分析,结果184名儿童“四苗”及时接税率为45．1％,以及时接种者为对照组,延迟接种者为观察组,进行Logistic回归分析。单因素分析结果显示：儿童出生在外地、是暂住户口、在外地居住3个月以上者、亲友中无从事医疗工作者是儿童“四苗”接种延迟的危险因素（P＜0.05）,父母亲文化程度越低,儿童出现“四苗”接种延迟的可能性越高,父母对有关的知识、信念得分愈高儿童发生“四苗”接种延迟的危险性也就愈小（P＜0．05）;其余因素对“四苗”接种延迟无显著影响。进一步的多因素Logstic回归分析,儿童出生地、亲戚朋友有无从事医疗工作、户口类型、信念得分四因素依次进入多元logisitic回归方程。     

19号染色体长臂部分重复致癫痫伴发育落后1例遗传及表型分析

目的:探讨1例癫痫伴运动发育落后的患儿的遗传学病因,为临床诊断和遗传咨询提供依据。方法:收集2020年1月因癫痫伴运动发育落后到河南省人民医院就诊的1例患儿及其父母外周血各2 mL,采用常规G显带分析患儿及其父母的外周血染色体核型,采用微阵列比较基因组杂交(aCGH)技术对患儿及其父母进行染色体片段重复/缺失进行分析。...     

Effect of acupuncture on adrenocortical hormone production: I. Variation in the ability for adrenocortical hormone production in relation to the duration of acupuncture stimulation.

The effect of acupuncture on adrenocortical hormone production in adult female albino rabbits of New Zealand strain was investigated. There was significant increase compared to the control cortisol and corticosterone following application of acupuncture at the locus Tsu-San-Li. In the non-locus group, such treatment resulted in only a transient raise followed by a significant fall in cortisol and corticosterone. Acupuncture treatment with electric current for 1 hour proved to be unique in that it gave rise to no biphasic change in the 14C uptake of the steroids. These results indicate that adrenal production of corticosterone and cortisol was enhanced by acupuncture and electroacupuncture at the Tsu-San-Li locus.     

2002—2010年上海市杨浦区居民肺癌发病与死亡分析

目的了解上海市崇明县肺癌发病及死亡的变化趋势,并根据现有发病数据预测今后肺癌发病趋势。方法收集崇明县1998—2013年肺癌发病和死亡数据及人口数据,分别计算粗发病率和死亡率、年龄别发病率和死亡率、世界人口标化发病率和死亡率以及年度变化百分比(APC)以描述年度变化趋势。结果1998—2013年崇明县肺癌发病7 275例,粗发病率为81.33/10万,男性、女性分别为122.36/10万、41.20/10万,男性明显高于女性。1998—2013年男性肺癌发病APC为1.70%,女性为4.97%;男、女标化的发病率均出现减缓趋势,女性发病增长速度高于男性,65岁以上老年人群发病增长速度高于青中年。1998—2013年崇明县肺癌死亡6 102例,粗死亡率为68.22/10万,男性、女性分别为103.91/10万、33.30/10万,男性明显高于女性。1998—2013年男性肺癌死亡APC为2.01%,女性为4.54%,女性死亡增长速度高于男性, 65岁以上老年人群女性死亡增长速度高于男性。结论崇明县肺癌粗发病率的增高主要受人口老龄化的影响,采取及时有效的预防措施将有助于降低崇明县肺癌的发病率和死亡率。     

Association between Serum Zinc and Toll-like-Receptor- Related Innate Immunity and Infectious Diseases in Well-Nourished Children with a Low Prevalence of Zinc Deficiency: A Prospective Cohort Study

Existing reports focus on zinc-associated immunity and infection in malnourished children; however, whether zinc also plays an important role in the immune homeostasis of the non-zinc-deficient population remained unknown. This study aimed to investigate the association between zinc status and toll-like receptor (TLR)-related innate immunity and infectious outcome in well-nourished children. A total of 961 blood samples were collected from 1 through 5 years of age. Serum zinc was analyzed, and mononuclear cells isolated to assess TNF-α, IL-6, and IL-10 production by ELISA after stimulation with TLR ligands. Childhood infections were analyzed as binary outcomes with logistic regression. The prevalence of zinc deficiency was 1.4–9.6% throughout the first 5 years. There was significant association between zinc and TLR-stimulated cytokine responses. Higher serum zinc was associated with decreased risk of ever having pneumonia (aOR: 0.94; 95% CI: 0.90, 0.99) at 3 years, and enterocolitis (aOR: 0.96; 95% CI: 0.93, 0.99) at 5 years. Serum zinc was lower in children who have had pneumonia before 3 years of age (72.6 ± 9 vs. 81.9 ± 13 μg/dL), and enterocolitis before 5 years (89.3 ± 12 vs. 95.5 ± 13 μg/dL). We emphasize the importance of maintaining optimal serum zinc in the young population.     

SNPs in the COX-2/PGES/EP signaling pathway are associated with risk of severe capecitabine-induced hand-foot syndrome

Cancer Chemotherapy and Pharmacology - Capecitabine is a widely used 5-fluorouracil oral prodrug. Hand-foot syndrome (HFS), one of the most common adverse events of capecitabine, impacts...     

Epstein‐Barr virus‐encoded latent membrane protein 1 promotes extracellular vesicle secretion through syndecan‐2 and synaptotagmin‐like‐4 in nasopharyngeal carcinoma cells

Increasing evidence indicates that extracellular vesicles (EVs) play an important role in cancer cell‐to‐cell communication. The Epstein‐Barr virus (EBV)‐encoded latent membrane protein 1 (LMP1), which is closely associated with nasopharyngeal carcinoma (NPC) pathogenesis, can trigger multiple cell signaling pathways that affect cell progression. Several reports have shown that LMP1 promotes EV secretion, and LMP1 trafficking by EVs can enhances cancer progression and metastasis. However, the molecular mechanism by which LMP1 promotes EV secretion is not well understood. In the present study, we found that LMP1 promotes EV secretion by upregulated syndecan‐2 (SDC2) and synaptotagmin‐like‐4 (SYTL4) through nuclear factor (NF)‐κB signaling in NPC cells. Further study indicated that SDC2 interacted with syntenin, which promoted the formation of the EVs, and SYTL4 is associated with the release of EVs. Moreover, we found that stimulation of EV secretion by LMP1 can enhance the proliferation and invasion ability of recipient NPC cells and tumor growth in vivo. In summary, we found a new mechanism by which LMP1 upregulates SDC2 and SYTL4 through NF‐κB signaling to promote EV secretion, and further enhance cancer progression of NPC.