全文获取类型
收费全文 | 51606篇 |
免费 | 4133篇 |
国内免费 | 441篇 |
专业分类
耳鼻咽喉 | 822篇 |
儿科学 | 1058篇 |
妇产科学 | 963篇 |
基础医学 | 8104篇 |
口腔科学 | 802篇 |
临床医学 | 4843篇 |
内科学 | 10298篇 |
皮肤病学 | 1687篇 |
神经病学 | 4407篇 |
特种医学 | 2927篇 |
外科学 | 5965篇 |
综合类 | 738篇 |
现状与发展 | 1篇 |
一般理论 | 16篇 |
预防医学 | 3346篇 |
眼科学 | 1353篇 |
药学 | 4394篇 |
中国医学 | 500篇 |
肿瘤学 | 3956篇 |
出版年
2023年 | 304篇 |
2022年 | 822篇 |
2021年 | 1354篇 |
2020年 | 744篇 |
2019年 | 1141篇 |
2018年 | 1297篇 |
2017年 | 1030篇 |
2016年 | 1499篇 |
2015年 | 1956篇 |
2014年 | 2324篇 |
2013年 | 2747篇 |
2012年 | 3894篇 |
2011年 | 3792篇 |
2010年 | 2338篇 |
2009年 | 1945篇 |
2008年 | 2748篇 |
2007年 | 2712篇 |
2006年 | 2423篇 |
2005年 | 2290篇 |
2004年 | 1949篇 |
2003年 | 1735篇 |
2002年 | 1598篇 |
2001年 | 1000篇 |
2000年 | 956篇 |
1999年 | 825篇 |
1998年 | 392篇 |
1997年 | 365篇 |
1996年 | 312篇 |
1995年 | 299篇 |
1994年 | 245篇 |
1993年 | 269篇 |
1992年 | 595篇 |
1991年 | 629篇 |
1990年 | 533篇 |
1989年 | 595篇 |
1988年 | 591篇 |
1987年 | 580篇 |
1986年 | 501篇 |
1985年 | 506篇 |
1984年 | 396篇 |
1983年 | 331篇 |
1982年 | 248篇 |
1981年 | 231篇 |
1980年 | 206篇 |
1979年 | 298篇 |
1978年 | 261篇 |
1977年 | 188篇 |
1974年 | 201篇 |
1973年 | 219篇 |
1972年 | 174篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
72.
73.
R Cotter R Johnson M Tumbelson J Dexter S Young C A Taylor F Cosmas W B Rowe L Lin 《JPEN. Journal of parenteral and enteral nutrition》1988,12(2):121-126
The ability of soybean oil lipid emulsions to affect essential fatty acid deficiency (EFAD) and plasma fatty acid distribution was studied in neonatal pigs. The test animals were maintained on a fat-free diet prior to administration of lipid emulsion. Plasma and red blood cell (RBC) membrane levels of essential [linoleic (C-18:2 omega 6) and arachidonic (C-20:4 omega 6)] and nonessential [palmitic (C-16, palmitoleic (C-16:1 omega 7), stearic (C-18), and oleic (C-18:1 omega 9)] fatty acids and the triene:tetraene ratio [5,8,11-eicosatrienoic acid (C-20:3 omega 9):arachidonic acid (C-20:4 omega 6)] were monitored to ascertain the establishment of EFAD and its correction. Nonessential fatty acids were studied, as these components of lipid therapy have received little attention. Results indicate that soybean oil emulsions are effective in reversing fatty acid profiles found in EFAD, and both essential and nonessential fatty acids are under strict metabolic control. 相似文献
74.
Eain M. Cornford Deborah Young James W. Paxton 《Cancer chemotherapy and pharmacology》1992,29(6):439-444
Summary The blood-brain barrier penetration of amsacrine and its analogs 9-({2-methoxy-4-[(methylsulfonyl)-amino]phenyl}amino)-,5-dimethyl-4-acridine carboxamide (CI-921) and M-[2-(dimethylamino)ethyl]-acridine-4-carboxamide (AC) was measured in the barbiturate-anesthetized mouse. After intracarotid administration, AC was almost completery extracted (90%) in a single transit through the brain capillaries, whereas CI-921 (20%) and amsacrine (15%) were moderately extracted. AC is retained in the brain; no loss of AC from the brain was apparent at 1, 2, 4, or 8 min after injection. In contrast, after intraportal administration, 75% of the AC, 94% of the CI-921, and 57% of the amsacrine was extracted in a single transit through the hepatic vasculature. Rather than being retained in the mouse liver, these acridine antitumor agents show time-dependent loss (t
1/2=10 min for amsacrine and AC, 24 min for CI-921). We conclude that unlike most antitumor agents, these acridine drugs appear to penetrate the blood-brain barrier readily.This study was supported by the Auckland Medical Research Foundation (New Zealand), by the Medical Research Foundation (New Zealand), by the National Science Foundation (United States/New Zealand Cooperative Science Program), by the United States Veterans Administration, and by NIH grant NS 25554 相似文献
75.
76.
The association between nitrate levels in public and private sources of drinking water and gastric cancer mortality in Wisconsin was investigated in a case-control study. All gastric cancer deaths of Wisconsin residents from 1982 through 1985 were compared with deaths from other causes (controls), and nitrate levels in the home drinking water of these residents were determined. Nitrate measures for public sources were obtained from historic nitrate data from municipal sources that existed in 1970. Nitrate measures for private water sources were obtained by testing the wells individually at the existing residences. Controls were matched individually to gastric cancer cases with respect to sex, year of birth, year of death, Wisconsin birth, and Wisconsin residency at the time of death. Matched-pair analyses were performed on the paired data, and the following levels of nitrate-nitrogen exposure were used as indicators of exposure: 0.5, 2.5, 5.0, and 10.0 mg/l. Matched-pair analysis was also performed for which private water supply constituted exposure. Odds ratios and 95% confidence intervals were, respectively, 0.92 (0.75, 1.12); 0.97 (0.74, 1.35); 0.86 (0.69, 1.08); 1.50 (0.12, 18.25); and 1.09 (0.82, 1.47) for exposure to private well-water sources. These results did not indicate an increased risk of gastric cancer at any level. 相似文献
77.
We tested the hypothesis that suppression of inward calcium current in presynaptic terminals is the cause of failure of synaptic transmission early during cerebral hypoxia. Postsynaptic responses in CA1 zone of hippocampal tissue slices were blocked either by the combined administration of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and 3-((+-)-2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP) or by lowering extracellular calcium concentration ([Ca2+]o). Repetitive orthodromic activation of central neurons caused transient decrease of [Ca2+]o (measured by ion selective microelectrodes) in neuropil, attributable to influx of Ca2+ in presynaptic terminals. Presynaptic [Ca2+]o responses were rapidly and reversibly suppressed when oxygen was withdrawn from hippocampal tissue slices. The 'resting' baseline level of [Ca2+]o declined at first gradually, then precipitously as in spreading depression (SD). Presynaptic volleys during high frequency train stimulation were also depressed somewhat before SD began. We conclude that (1) presynaptic Ca2+ currents fail during hypoxia, perhaps because 'resting' intracellular free Ca2+ activity is increased and, in part, also because of partial failure of presynaptic impulse conduction; (2) the influx of Ca2+ into brain cells in hypoxic spreading depression is not mediated by glutamate/aspartate dependent channels. 相似文献
78.
79.
80.
Osteonectin (SPARC, culture shock protein, BM-40) is a widely distributed glycoprotein which binds calcium and several extracellular matrix proteins, including interstitial collagens and thrombospondin, but whose physiologic role remains undefined. In the present studies, we have demonstrated that immunoreactive osteonectin is present in the distal cortical tubule and medullary tubules of murine kidney. We surveyed the renal epithelial cell lines LLC-PK1, MDCK, and OK for the expression of mRNA encoding osteonectin. We found that osteonectin mRNA is expressed by LLC-PK1 and OK cells but not by MDCK cells, as well as by adult kidney from several species. Calcitonin and vasopressin, agents which increase cAMP in these cells, were found to decrease steady-state osteonectin mRNA concentrations. We found that LLC-PK1 cells produced osteonectin protein, that the protein was localized to intracellular granules, and that the protein bound hydroxyapatite in vitro. Pulse-chase analysis revealed that osteonectin was secreted from the cell layer to the medium after a lag time of four to six hours and was secreted preferentially from the basolateral domain of the cell. The preferential secretion of the calcium-binding protein osteonectin from the renal epithelial cell is consistent with several possible functions, including a structural extracellular matrix protein, a participant in transepithelial ion transport, and an inhibitor of extracellular calcification. 相似文献