全文获取类型
收费全文 | 7646篇 |
免费 | 441篇 |
国内免费 | 53篇 |
专业分类
耳鼻咽喉 | 95篇 |
儿科学 | 150篇 |
妇产科学 | 45篇 |
基础医学 | 1025篇 |
口腔科学 | 141篇 |
临床医学 | 580篇 |
内科学 | 2010篇 |
皮肤病学 | 127篇 |
神经病学 | 482篇 |
特种医学 | 381篇 |
外科学 | 1371篇 |
综合类 | 22篇 |
一般理论 | 1篇 |
预防医学 | 312篇 |
眼科学 | 81篇 |
药学 | 387篇 |
中国医学 | 14篇 |
肿瘤学 | 916篇 |
出版年
2023年 | 79篇 |
2022年 | 107篇 |
2021年 | 280篇 |
2020年 | 158篇 |
2019年 | 219篇 |
2018年 | 246篇 |
2017年 | 168篇 |
2016年 | 222篇 |
2015年 | 185篇 |
2014年 | 269篇 |
2013年 | 310篇 |
2012年 | 446篇 |
2011年 | 512篇 |
2010年 | 278篇 |
2009年 | 199篇 |
2008年 | 324篇 |
2007年 | 384篇 |
2006年 | 363篇 |
2005年 | 349篇 |
2004年 | 342篇 |
2003年 | 283篇 |
2002年 | 320篇 |
2001年 | 183篇 |
2000年 | 201篇 |
1999年 | 201篇 |
1998年 | 57篇 |
1997年 | 55篇 |
1996年 | 38篇 |
1995年 | 41篇 |
1994年 | 46篇 |
1993年 | 39篇 |
1992年 | 125篇 |
1991年 | 111篇 |
1990年 | 114篇 |
1989年 | 103篇 |
1988年 | 99篇 |
1987年 | 88篇 |
1986年 | 74篇 |
1985年 | 66篇 |
1984年 | 61篇 |
1983年 | 42篇 |
1982年 | 26篇 |
1981年 | 21篇 |
1980年 | 21篇 |
1979年 | 41篇 |
1978年 | 19篇 |
1977年 | 30篇 |
1975年 | 24篇 |
1972年 | 18篇 |
1969年 | 18篇 |
排序方式: 共有8140条查询结果,搜索用时 15 毫秒
991.
992.
T Hirata K Akagi S Baba F Tsurumi T Nakata T Ikeda H Doi 《Journal of cardiothoracic surgery》2012,7(1):77
ABSTRACT: Congenital pulmonary arteriovenous fistula (PAVF) is a rare disease which causes hypoxemia by shunting deoxygenated blood from the pulmonary artery into pulmonary venous return. Lung transplantation is the most effective therapy to treat severe, diffuse PAVF. However, the availability of lungs for transplantation is limited in most parts in the world. For patients with diffuse PAVF affecting only one side of the lungs, ipsilateral pulmonary artery banding (PAB) is an effective treatment, but not yet standard of care. We report successful treatment of a patient with diffuse left-sided PAVF with PAB. We believe that PAB is an effective therapy for severe unilateral PAVF and may serve as a bridge to lung transplantation. 相似文献
993.
Fupin Hu Jessica A. O'Hara Jesabel I. Rivera Yohei Doi 《Antimicrobial agents and chemotherapy》2014,58(11):6953-6957
We characterized 30 community-associated extended-spectrum-β-lactamase-producing Escherichia coli isolates collected from five hospitals in the United States. Nineteen sequence types were identified. All sequence type 131 (ST131) isolates had the fimH30 allele. IncFII-FIA-FIB was the most common replicon type among the blaCTX-M-carrying plasmids, followed by IncFII-FIA and IncA/C. Restriction analysis of the IncFII-FIA-FIB and IncFII-FIA plasmids yielded related profiles for plasmids originating from different hospitals. The plasmids containing blaCTX-M or blaSHV were stably maintained after serial passages. 相似文献
994.
995.
Reem Almaghrabi Cornelius J. Clancy Yohei Doi Binghua Hao Liang Chen Ryan K. Shields Ellen G. Press Nicole M. Iovine Bethany M. Townsend Marilyn M. Wagener Barry Kreiswirth M. Hong Nguyen 《Antimicrobial agents and chemotherapy》2014,58(8):4443-4451
We measured in vitro activity of plazomicin, a next-generation aminoglycoside, and other aminoglycosides against 50 carbapenem-resistant Klebsiella pneumoniae strains from two centers and correlated the results with the presence of various aminoglycoside-modifying enzymes (AMEs). Ninety-four percent of strains were sequence type 258 (ST258) clones, which exhibited 5 ompK36 genotypes; 80% and 10% of strains produced Klebsiella pneumoniae carbapenemase 2 (KPC-2) and KPC-3, respectively. Ninety-eight percent of strains possessed AMEs, including AAC(6′)-Ib (98%), APH(3′)-Ia (56%), AAC(3)-IV (38%), and ANT(2″)-Ia (2%). Gentamicin, tobramycin, and amikacin nonsusceptibility rates were 40, 98, and 16%, respectively. Plazomicin MICs ranged from 0.25 to 1 μg/ml. Tobramycin and plazomicin MICs correlated with gentamicin MICs (r = 0.75 and 0.57, respectively). Plazomicin exerted bactericidal activity against 17% (1× MIC) and 94% (4× MIC) of strains. All strains with AAC(6′)-Ib were tobramycin-resistant; 16% were nonsusceptible to amikacin. AAC(6′)-Ib combined with another AME was associated with higher gentamicin, tobramycin, and plazomicin MICs than AAC(6′)-Ib alone (P = 0.01, 0.0008, and 0.046, respectively). The presence of AAC(3)-IV in a strain was also associated with higher gentamicin, tobramycin, and plazomicin MICs (P = 0.0006, P < 0.0001, and P = 0.01, respectively). The combination of AAC(6′)-Ib and another AME, the presence of AAC(3)-IV, and the presence of APH(3′)-Ia were each associated with gentamicin resistance (P = 0.0002, 0.003, and 0.01, respectively). In conclusion, carbapenem-resistant K. pneumoniae strains (including ST258 clones) exhibit highly diverse antimicrobial resistance genotypes and phenotypes. Plazomicin may offer a treatment option against strains resistant to other aminoglycosides. The development of molecular assays that predict antimicrobial responses among carbapenem-resistant K. pneumoniae strains should be a research priority. 相似文献
996.
Louise M. Oleksiuk M. Hong Nguyen Ellen G. Press Cassaundra L. Updike Jessica A. O'Hara Yohei Doi Cornelius J. Clancy Ryan K. Shields 《Antimicrobial agents and chemotherapy》2014,58(2):1195-1199
We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistin-doripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill, −5.74 versus −2.88; P = 0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (−5.65 versus −2.43; P = 0.04). 相似文献
997.
998.
Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial effects in many inflammatory disorders. Although the mechanism of eicosapentaenoic acid and docosahexaenoic acid action is still not fully defined in molecular terms, recent studies have revealed that, during the course of acute inflammation, omega-3 polyunsaturated fatty acid-derived anti-inflammatory mediators including resolvins and protectins are produced. This review presents recent advances in understanding the formation and action of these mediators, especially focusing on the LC-MS/MS-based lipidomics approach and recently identified bioactive products with potent anti-inflammatory property. 相似文献
999.
Junya Sakamoto Yosuke Morimoto Shun Ishii Jiro Nakano Yoshitaka Manabe Minoru Okita Toshiyuki Tsurumoto 《Journal of Physical Therapy Science》2014,26(2):203-208
[Purpose] The aim of this study was to examine the incidence and patterns of referred
pain in patients with hip disease, as well as the nerve distribution in the hip and knee
joints of 2 cadavers. [Subjects and Methods] A total of 113 patients with hip joint
disease were included in the investigation. The incidence of regional pain and referred
pain patterns were evaluated before and after arthroplasty. Two cadavers were
macroscopically observed to verify the nerve innervation of the hip and knee joints.
[Results] Anterior knee pain was observed preoperatively in 13.3% (in resting) and 33.6%
(in motion) of the patients, which was comparable with the incidence of greater trochanter
pain. In addition, the preoperative incidence rates of knee pain in resting and motion
markedly decreased postoperatively. Of note is the remarkable incidence of pain radiating
to the ventral lower limb. An anteromedial innervation was determined in the cadavers by
the articular branches of the obturator and femoral nerve, which supply small branches to
the knee joints. [Conclusion] Our results suggest that the distribution of the incidence
of pain among the patients with hip disease is diverse owing to the sensory distribution
of the femoral and obturator nerves.Key words: Hip joint disease, Referred pain, Macroscopic anatomy 相似文献
1000.
There is a risk of unnecessary extensive incision because of swelling after the subcutaneous injection; however, removing completely the injected organophosphate by making a skin incision before the appearance of toxic symptoms could reduce sequelae. 相似文献