Examination of lymph and bile composition following experimental liver transplantation in rat

The lymph flow of the thoracic duct, the protein content of the lymph, bile flow and bile composition are studied during the first three hours of the recirculation phase in experimental liver transplantation. It is established that the lymph flow and the protein content of the thoracic duct decrease as a result of the interruption of hepatic lymph flow of a high protein concentration. The change in bile composition and flow is due to the reduced bile acid excretion of the transplanted hepatic tissue.     

Therapeutic experiences with Budd-Chiari syndrome: report of 100 cases

One-hundred cases of Budd-Chiari syndrome were treated from December 1982 to March 1988. There were 62 males and 38 females. Their ages ranged from 15 to 62 years averaged 32.6 years Seventy-six cases had intractable ascites, 56 had esophageal varices and 22 had upper gastrointestinal bleeding. There were 37 cases with membranous obstruction, 57 with occlusion of the inferior vena cava above the confluence of the hepatic veins and 6 with occlusion of hepatic veins. Eighty-one cases (81%) were operated upon. Operative mortality was 8.6% (7/81). Follow-up from 2 to 63 months revealed that 60 operated cases (74.1%) had good results, while 11 of 19 (58%) patients treated conservatively died within two months after admission. It is concluded that the operative procedure must be tailored to the etiology and pathology. The mesoatrial shunt is the operation of choice for occlusion of the retrohepatic IVC and hepatic veins, the cava-atrial shunt for occlusion of the IVC and patent hepatic veins, membranotomy for IVC web, and the meso-caval shunt for intrahepatic venous occlusion. For those who also have superior vena cava compression syndrome, an innominate-atrial shunt should be added.     

CURATIVE EFFECT OF LICORICE ACID ZINC ON CHILDREN WITH LOW SERUM ZINC

Zinc is closely related to children's health and growth.' We selected 120 children with low serum zinc. Adopting random double-blind method, we treated two groups of children,. 60 each, with sulphate zinc syrup and licorice acid zinc capsules respectively.     

Lung cancer and prior tuberculosis infection in Shanghai

In a population-based case-control study of lung cancer in Shanghai involving interviews during 1984-86 with 1,405 cancer patients and 1,495 controls, a significant 50% elevation in the risk of lung cancer, adjusted for cigarette smoking, was observed among persons who had a history of tuberculosis. Among those diagnosed with tuberculosis within the past 20 years, the risk exceeded 2.5-fold. In males the lung cancers tended to occur on the same side as the previous tuberculosis infection. For both sexes, the effect of recent tuberculosis was most apparent for adenocarcinoma and peripheral tumours. No relationship was found between lung cancer risk and the type of tuberculosis therapy, including use of isoniazid. The findings suggest that tuberculosis may predispose to lung cancer, with the association most apparent among recent survivors of the infection.     

Axonal transport of dopamine D1 receptors in the rat brain

Binding of a specific dopamine D₁ receptor antagonist,¹²⁵I-SCH 23982, was measured in rat brain sections by quantitative autoradiography at various time intervals, following a knife cut through the striatonigral pathway. Twenty-four hours after lesioning, accumulations of D₁ receptor binding sites were found in sagittal sections both rostral and caudal to the lesion site. No other regions studied (caudate-putamen, nucleus accumbens, olfactory tubercle, and substantia nigra pars reticulata) showed any change in D₁ receptor binding 24h after the lesion. In brain sections obtained 10 days after lesioning, only the substantia nigra pars reticulata had a significant decrease in D₁ receptors ipsilateral to the lesion. These findings suggest the possibility of a presence of bidirectional axonal transport of D₁ receptors in rat striatonigral pathway.     

Biochemical, clinical and genetic analysis of various aminoacidopathies (non-ketotic hyperglycemia, maple syrup urine disease, histidinemia, tyrosinemia)]

The genetical types were classified according to the clinical findings and biochemical results in cases of 13 newborn/children suffering from various aminoacidopathies. The genetical types were: 3 neonatal and 4 infantile types were found out of 7 non-ketotic disease (MSUD) patient was infantile type with 9.1 per cent keto acid decarboxylase activity in leukocyte homogenate. Among the 3 histidinemic patients 1 was severe neonatal type and 2 cases were chronic types. The 2 treated tyrosinemic children proved to be type III. (chronic with rickets).