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41.
The cellular and regional distribution of glutathione (GSH) and GSH-related enzyme systems involved in cellular defense against reactive oxygen species and electrophilic xenobiotics in the nervous system has been extensively studied. However, little is known about the subcellular distribution of GSH systems in brain tissue and cultured neural cells. The present study investigates the distribution of mitochondrial and cytosolic GSH and GSH-related enzymes in cultured cerebellar astrocytes and granule cells, and compares them with levels in the adult rat cerebellum. Cytosolic GSH levels and cytosolic activities of glutathione reductase (GR), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in astrocytes were 57, 153, 245, and 92% higher than those found in granule cells, respectively. In contrast, granule cells contained significantly higher mitochondrial GSH levels than astrocytes. Granule cells also demonstrated comparable mitochondria/cytosolic concentrations of GSH and GR, GPX and GST activities to those observed in the cerebellar tissue, whereas ratios in astrocytes were markedly lower. Although in vitro treatments with 100 μM ethacrynic acid depleted both cytosolic and mitochondrial GSH in cultured astrocytes and granule cells in a time-dependent fashion, cellular GSH in granule cells was more resistant to the GSH-depleting agent than astrocytes. These results suggest that although GSH and GSH-related enzymes are abundant in cytosolic compartments of astrocytes, mitochondrial pools are relatively small. Since brain mitochondria are sites of significant hydrogen peroxide generation, the mitochondrial localization of GSH and its associated enzymes in neural cells provide important defenses against toxic oxygen species in the nervous system. Differences in subcellular distribution of GSH systems in individual neural cell types may provide a basis for selective cellular and/or subcellular expression of neurotoxicity. 相似文献
42.
甲基强的松龙对低温保存大鼠肝脏的保护作用 总被引:2,自引:1,他引:1
应用Wistar大鼠肝脏离体灌流模型,用CMU—1号液,含有甲基强的松龙的CMU—1号液,以及缺血前预用甲基强的松龙后再用CMU—1号液分别对肝脏进行灌洗保存。检测LDH、ALT、肝组织匀浆SOD活性和MDA含量,并观察肝组织结构。结果表明:甲基强的松龙对低温保存的离体大鼠肝脏具有保护作用 相似文献
43.
复方栀子冲剂栀子甙薄层扫描测定 总被引:11,自引:0,他引:11
应用薄层扫描法测定了复方栀子冲剂中栀子甙的含量,对实验条件,以正交试验法进行优选,确定了最佳方案,排除了干扰,得到了满意的效果。 相似文献
44.
Ye Guoji Machiko Orita Kako Tashiro Hiroko Abe 《Naunyn-Schmiedeberg's archives of pharmacology》1994,349(3):318-323
The effects of glycyrrhetinic acid (GA), an aglycon of glycyrrhizin extracted from the roots of Glycyrrhizae radix, on puromycin aminonucleoside (PA) nephrosis were studied in rats. Urine protein excretion in female rats (130g–150g) receiving PA (50 mg/kg) alone was significantly elevated on the 2nd day after injection of PA and reached a peak on the 14th day. Urinary protein on the 14th day was reduced to 74% in animals treated with GA (20 mg/kg) starting on the 2nd day after injection of PA. The increase in serum cholesterol and the decrease in serum protein were also suppressed by GA. Observation by electron microscopy revealed that the degree of abnormality in glomerular epithelial cells, i.e. loss or fusion of foot processes, was lower in the rats treated with GA after PA injection than in the rat treated with PA alone. Moreover, pretreatment with GA did not suppress urinary protein excretion but when it was given at the same time as PA and after PA a significant decrease in urinary protein excretion was observed.
Correspondence to: H. Abe at the above address 相似文献
45.
脊髓手术中体感诱发电位监测的临床研究 总被引:3,自引:0,他引:3
报告30例脊髓手术中体感诱发电位(SEP)连续监测的临床研究结果。SEP记录包括脊髓SEP(SSEP)和皮层SEP(SCEP)。麻醉药物对SEP有一定程度影响,SCEP相对较大。认为,至少术中SEP潜伏期延长不超过8%和波幅降低不超过50%,不会引起术后并发症,超过该范围由于病例较少,尚不能肯定与预后的关系,需进一步探讨。 相似文献
46.
本文在分析黑龙江省妇幼保健机构设置现状的基础上,论述了在社会主义市场经济新形势下,妇幼保健机构发展的指导思想、模式与对策。 相似文献
47.
急性肠系膜静脉血栓形成16例临床分析 总被引:1,自引:0,他引:1
目的 分析急性肠系膜静脉血栓形成 (ASMVT)的临床特征和诊断方法。方法 对北京友谊医院 1985年 10月至 2 0 0 2年 10月确诊的 16例ASMVT的临床资料进行分析 ,并结合文献 ,总结ASMVT的临床特征和诊断方法。结果 16例ASMVT患者 ,年龄 19~ 6 4岁 (平均 4 5 9岁 )。主要症状有腹痛 ( 16 / 16 )、腹胀 ( 16 / 16 )、呕吐 ( 10 / 16 )、发热 ( 8/ 16 ) ,主要体征有腹部膨隆 ( 16 / 16 )、腹膜刺激征( 16 / 16 )。误诊率 75 % ( 12 / 16 ) ,死亡率 4 4 % ( 7/ 16 )。结论 ASMVT的临床表现有一定的特征 ,早期彩色超声检查、诊断性腹腔穿刺、结合CT或肠系膜上动脉造影异常发现可对ASMVT做出正确的诊断 ,早期手术可以降低死亡率 相似文献
48.
目的:探讨Mirizzi综合征的发病机理、临床表现、影像学诊断及术前诊断的重要价值.方法:查阅了大量的相关资料文献,进行对比、分析、总结归纳.结果:Mirizzi综合征是胆道系统感染的一种特殊类型,临床少见,极易造成漏诊和误诊,在术中造成不必要的胆道损伤和胆总管探查,影像学检查在诊断此综合征方面有较多的独特优势.结论:Mirizzi综合征术前可以通过影像学检查尤其是超声检查明确诊断. 相似文献
49.
卓见 《中国医学文摘:外科学分册英文版》2007,16(2):141-141
Objective To compare the safety and short-term efficacy of thulium laser resection of the prostate-Tangerine technique (TmLRP-TT) and treatment of benign prostatic hyperplasia (BPH) patients.Methods A total of 124 patients who were diagnosed with BPH were randomly divided into 2 groups: 相似文献
50.