全文获取类型
收费全文 | 1624篇 |
免费 | 67篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 48篇 |
儿科学 | 82篇 |
妇产科学 | 28篇 |
基础医学 | 100篇 |
口腔科学 | 55篇 |
临床医学 | 121篇 |
内科学 | 526篇 |
皮肤病学 | 70篇 |
神经病学 | 80篇 |
特种医学 | 41篇 |
外科学 | 329篇 |
综合类 | 8篇 |
预防医学 | 24篇 |
眼科学 | 66篇 |
药学 | 50篇 |
中国医学 | 1篇 |
肿瘤学 | 71篇 |
出版年
2023年 | 12篇 |
2022年 | 24篇 |
2021年 | 33篇 |
2020年 | 15篇 |
2019年 | 25篇 |
2018年 | 24篇 |
2017年 | 20篇 |
2016年 | 38篇 |
2015年 | 38篇 |
2014年 | 74篇 |
2013年 | 74篇 |
2012年 | 113篇 |
2011年 | 103篇 |
2010年 | 61篇 |
2009年 | 61篇 |
2008年 | 123篇 |
2007年 | 171篇 |
2006年 | 119篇 |
2005年 | 114篇 |
2004年 | 101篇 |
2003年 | 73篇 |
2002年 | 64篇 |
2001年 | 38篇 |
2000年 | 26篇 |
1999年 | 27篇 |
1998年 | 7篇 |
1997年 | 4篇 |
1996年 | 10篇 |
1995年 | 8篇 |
1994年 | 7篇 |
1993年 | 3篇 |
1992年 | 11篇 |
1991年 | 7篇 |
1990年 | 7篇 |
1989年 | 8篇 |
1988年 | 3篇 |
1987年 | 11篇 |
1986年 | 6篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1977年 | 2篇 |
1975年 | 2篇 |
1973年 | 2篇 |
1970年 | 2篇 |
1967年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有1700条查询结果,搜索用时 15 毫秒
91.
3C syndrome: another case 总被引:2,自引:0,他引:2
92.
93.
Ozhan H Akdemir R Yazici M Gündüz H Duran S Uyan C 《Emergency medicine journal : EMJ》2004,21(6):742-744
An unusual type of food poisoning is commonly seen in the Black Sea coast of Turkey attributable to andromedotoxin containing toxic honey ingestion. This study is a retrospective case series of 19 patients admitted to an emergency department in 2002, poisoned by "mad" honey. All of the patients had the complaints of nausea, vomiting, sweating, dizziness, and weakness, several hours after ingesting "mad" honey. Physical examination showed hypotension in 15 patients, sinus bradycardia in 15, and complete atrioventricular block (AVB) in four patients on admission. Two patients with bradycardia and two with AVB fell and injured their heads. Three of them presented with local haematoma. One patient had a 6 cm cut on his head without any neurological deficit and his cranial computed tomography imaging was normal. Hypotension and conduction disorders resolved with atropine treatment, resulting in complete recovery within 24 hours. 相似文献
94.
Burhan Özalp Ömer Berköz Mustafa Aydınol 《Journal of plastic surgery and hand surgery》2018,52(1):7-13
Objective: The aim of this study was to assess the efficacy of suction-assisted liposuction (SAL) in Simon grade 2b gynecomastia and its effect on sternal notch to nipple areola (SNN) distance.Methods: A retrospective analysis was performed on 21 patients with grade 2b gynecomastia who underwent SAL. Preoperative and postoperative SNN distances of the patients were measured, the results were analysed using a Mann–Whitney U test and a p-value <.05 was accepted as statistically significant. Aesthetic results were evaluated by the surgical team considering five criteria: breast size, breast shape, nipple-areolar complex positioning, scarring, and skin tightness of the breast envelope. A 10-point Likert scale was used to assess patient satisfaction with SAL surgery.Results: All of the patients were followed up for an average period of 17.8 months (range?=?12–28 months). The mean amount of lipoaspirate was 232?mL per breast (range?=?190–310?mL). The mean preoperative SNN distance was 22.3?cm (range?=?20–23.5?cm), whereas postoperative was 21.3?cm (range?=?19.2–22.8?cm); the difference was statistically significant (p?.05). There was one case of nipple areola necrosis, three hypoesthesia, five persistent pains, and four slight buttonhole deformities. The aesthetic result was evaluated as very good by the surgical team, and the overall patient satisfaction rate in terms of breast shape and volume was 92%.Conclusions: It was concluded that SAL provides a good aesthetic outcome in patients with Simon grade 2b gynecomastia and shortens the SNN distance by 1?cm, but further clinical studies are required to support this conclusion. 相似文献
95.
96.
Numan Gorgulu Berna Yelken Yasar Caliskan Ali Elitok Arif Oguzhan Cimen Halil Yazici Huseyin Oflaz Ebru Golcuk Ahmet Ekmekci Aydin Turkmen Alaattin Yildiz Mehmet Sukru Sever 《Clinical transplantation》2010,24(5):678-684
Gorgulu N, Yelken B, Caliskan Y, Elitok A, Cimen AO, Yazici H, Oflaz H, Golcuk E, Ekmekci A, Turkmen A, Yildiz A, Sever MS. Endothelial dysfunction in hemodialysis patients with failed renal transplants.Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01160.x© 2009 John Wiley & Sons A/S. Abstract: Background: Endothelial dysfunction (ED) is a common precursor and denominator of cardiovascular events including development of atherosclerosis. In this cross‐sectional study, we aimed to investigate ED, measured by coronary flow reserve (CFR) in hemodialysis (nHD) patients who were never transplanted and patients with failed renal transplants restarting hemodialysis (fTx‐HD). Methods: Forty nHD (24 males, mean age 39 ± 9 yr) and 43 fTx‐HD patients (27 males, mean age 36 ± 9 yr) were included in the study. Clinical and biochemical parameters, including high‐sensitive C‐reactive protein (hs‐CRP) levels were determined. Also, CFR measurements were used to evaluate ED. Results: There were no significant differences regarding age, gender, smoking status, systolic and diastolic blood pressure levels, mean duration of HD treatment as well as Kt/V(urea) values between the two groups. Time spent on dialysis in the nHD group and dialysis duration following failure of renal allograft in the fTx‐HD group were similar. Serum creatinine, hemoglobin, hematocrit, calcium and phosphorus levels were similar between the two groups as well. When compared to nHD group, serum total cholesterol (139 ± 3 vs. 154 ± 3 mg/dL, p = 0.045), serum albumin (3.8 ± 0.3 g/dL vs. 4.1 ± 0.2 g/dL, p < 0.0001) and CFR (1.60 ± 0.2 vs. 1.75 ± 0.3, p = 0.028) levels were significantly lower, while serum hs‐CRP levels (11 ± 15 mg/L vs. 3 ± 4 mg/L, p = 0.001) were significantly higher in the fTx‐HD group. Serum hs‐CRP negatively correlated (r = ?0254, p = 0.021), while serum albumin positively correlated (r = 0402, p = 0.001) with CFR values. Conclusion: ED is more prominent in fTx‐HD than the nHD patients. Inflammation, caused by failed renal allograft can be responsible for this abnormality. 相似文献
97.
Cakir E Yilmaz A Demirag F Oguztuzun S Sahin S Yazici UE Aydin M 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2011,119(9):574-580
We evaluated the clinicopathological characteristics and prognostic significance of lung adenocarcinoma with micropapillary pattern (MPP) and analyzed the expression of apoptosis-related markers: caspase-3, bcl-2, and p53. A series of 166 lung adenocarcinoma that had been surgically resected between 2004 and 2009 were reviewed. Histopathologic patterns, presence of tumor necrosis, mitosis, lymphovascular and perineural invasion, the status of pleura, and tumor differentiation were examined. Of the 166 patients; 71 were stage I, 35 stage II, 51 stage III, and nine stage IV. Histologically they were divided into two groups: MPP-positive (n = 55) and MPP-negative (n = 111). The following items were significantly more frequent in the MPP positive group: female gender (p = 0.03), lymph node metastasis (p = 0.031), and pleural invasion (p = 0.045). Age, smoking status, tumor stage, lymphatic invasion, perineural invasion, mitotic count, and survival rates had no statistically significant difference between groups (p > 0.05). In MPP positive tumors, visceral pleural invasion was identified significantly more frequent than in MPP negative tumors, at stage I. Tumors with MPP showed elevated expressions of caspase-3 (94.5%), p53 (60%), and bcl-2 (54.5%). In MPP positive group, the expression of these three markers had no statistically significant impact on survival. In whole population, bcl-2 expression was correlated with a better outcome. We conclude that MPP is associated with poor prognostic factors both in early and late stages in lung adenocarcinoma. Bcl-2 provides prognostic information independent from the MPP. 相似文献
98.
Prominent ear deformity is a common congenital ear deformity. Prominent ear deformity includes components such as valgus of
concha, failure of scaphal folding, conchal hypertrophy, and prominent lobule. The deformity and the elastic properties of
the ear cartilage determine the method of surgical correction in each case. Concha-mastoid suture, conchal excision, and posterior
auricular muscle excision are different treatment options for mild to severe cases of conchal hypertrophy and valgus deformity.
In this article we present a method of conchal excision, combined with a posterior auricular muscle flap, to repair severe
conchal hypertrophy or valgus deformity. Six patients (11 ears) were operated on using this method. The results obtained were
satisfactory. Postoperative results at 6 months were satisfactory in all patients. The smoothness and the natural appearance
of the conchal bowls were notable in all patients. In contrast to the early methods of utilizing the posterior auricular muscle
by transposing to the scapha or excising, its usage as a muscle flap for conchal hypertrophy and valgus deformity may be a
promising option for the future. 相似文献
99.
Köseoğlu B Yilmaz E Ceylan K Uzun E Bayram I Hizli F 《International urology and nephrology》2009,41(1):85-91
Introduction The aim of the present study was to evaluate the effects of erythropoietin (EPO) on the histopathology of testes after unilateral
testicular torsion and detorsion.
Materials and methods Twenty-five male Sprague–Dawley rats weighing 120 g were used in this study. The rats were randomly divided into three groups,
a sham group consisting of five rats and the other two groups consisting of ten rats. In group 1 (sham group), right orchiectomy
with no additional intervention was performed. In group 2 (T/D group), torsion was created by rotating the testis 720° in
a clockwise direction for 4 h. After a 4-h torsion period, the right testis was detorted and replaced into the scrotum for
4 h. After the torsion, 0.5 cc 0.9% NaCl solution was injected once and three times in a week (total 12 doses). In group 3
(T/D + erythropoietin; EPO group), the same surgical procedure was done as in group 1, but EPO 1,000 IU/kg was injected just
before the detorsion and three times in a week. At the end of each procedure, bilateral orchiectomies were performed for the
histopathological examinations in all groups.
Results We examined the testes weight, vascularization of the region between the seminiferous tubules, percentage of necrotic seminipherous
tubules, and maturation of spermatogenesis in terms of necrosis, sertoli cells, maturation arrest of spermatogenesis, hypospermatogenesis,
and normal spermatogenesis of torsioned testis tissues with and without EPO treatment. Extremely significant differences in
testicular weight were observed in group 1 compared to groups 2 and 3 (P < 0.001).
Conclusion Administration of EPO significantly influenced the rescue of testicular function by preserving the intact seminiferous tubular
morphology, lowering the percentage of necrotic seminipherous tubules, and significantly reducing histological damage (P < 0.05). 相似文献
100.
Abaci A Sen N Yazici H Tulmac M Türkoglu S Tavil Y Yalcin R 《Coronary artery disease》2007,18(6):463-469
OBJECTIVES: Diabetic patients tend to have more extensive and diffuse coronary artery disease (CAD) that may contribute to the less favorable outcomes in them. The aim of this study was to elucidate the predictors of the angiographic severity and extent of CAD in patients with diabetes. METHODS: A total of 203 diabetic patients (116 men; mean age, 61.9+/-10.8) who were referred for a first coronary angiogram were included. The extent and severity of CAD was assessed in several ways. The first was a simple classification in one-vessel, two-vessel, and three-vessel disease scoring system. The total numbers of segments with > or = 20 and > or = 50% stenosis were calculated as CASS 20 and CASS 50 scores, respectively. Hamsten and Gensini scores were also calculated. RESULTS: Of the 203 patients included in the study, 175 (86.2%) had CAD. Multivariate ordinal logistic regression analysis showed that age (Wald 5.741, P=0.017), glomerular filtration rate (Wald 5.032, P=0.025), previous myocardial infarction (Wald 10.955, P=0.001), and family history of CAD (Wald 7.236, P=0.007) were independent predictors of the severity of CAD, as assessed by the clinical zero-vessel to three-vessel disease scoring system. On stepwise multiple linear regression analysis, glomerular filtration rate was an independent predictor of the CASS 20 (r=-0.221, P=0.004), CASS 50 (r=-0.239, P=0.005), Gensini (r=-0.328, P<0.001), and Hamsten (r=-0.320, P<0.001) scores. Previous myocardial infarction was an independent predictor of the CASS 50 (r=0.355, P<0.001), Gensini (r=0.350, P<0.001), and Hamsten (0.256, P<0.001) scores. Age and sex were independent predictors for the CASS 50 (r=0.174, P=0.039; r=0.172, P=0.016, respectively) and Hamsten (r=0.212, P=0.011; r=0.244, P=0.001, respectively) scores. CONCLUSION: Renal function is one of the most important factors associated with the extent and severity of coronary atherosclerosis, whereas classical coronary risk factors and the degree of metabolic control were not associated with the severity of coronary atherosclerosis in diabetic patients. 相似文献