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101.
Ekici A Yilmaz S Ekici M Kalpaklioğlu F Karadeniz Y Arslan M Iteginli A Kara T Kurtipek E 《Clinical science (London, England : 1979)》2003,105(2):181-185
The perception of dyspnoea differs between subjects with obstructive pulmonary diseases, partly because the underlying mechanisms for bronchoconstriction are different. We investigated the perception of bronchoconstriction in subjects with bronchiectasis, asthma and chronic bronchitis and possible contributing factors. Forty-seven non-smoking subjects with bronchiectasis, 50 subjects with asthma and 31 with chronic bronchitis were challenged with histamine. The Borg score was assessed before and after each challenge. The perception score corresponding to a fall in the forced expiratory volume in 1 s (FEV(1)) by 20% (PS(20)) was calculated. The mean values of DeltaBorg/DeltaFEV(1) (the Borg score change divided by the change in FEV(1) as a percentage of the baseline FEV(1)) and PS(20) of subjects with bronchiectasis and chronic bronchitis were significantly lower than in subjects with asthma after histamine challenge. The ratio of non-perceivers was higher in bronchiectasis (25.5%) and in chronic bronchitis (32.3%) than in asthma (4.0%). When all subjects were considered, DeltaBorg/DeltaFEV(1) values were significantly related to female sex ( r (2)=11.5%, P =0.0001), but not to age, duration of the disease, PD(20) or baseline FEV(1)%. The present study indicates that perception of histamine-induced bronchoconstriction is lower in patients with bronchiectasis and chronic bronchitis than in asthmatic patients, and that sex partially contributes to this difference. 相似文献
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105.
Hasan Ari Selma Ari Ercan Erdoğan Osman Tiryakioğlu Yasemin Üstündağ Kağan Huysal Vedat Koca Tahsin Bozat 《Heart and vessels》2010,25(1):19-26
The aim of this study is to investigate if serum asymmetric dimethylarginine (ADMA) levels can predict restenosis and major
adverse cardiac events (MACE) in patients who undergo percutaneous coronary interventions. The most important cause of restenosis
following percutaneous coronary intervention is neointimal hyperplasia. Nitric oxide (NO) prevents the neointimal hyperplasia
growing. Asymmetric dimethylarginine is a competitive inhibitor of NO synthesis. The effect of ADMA on the restenosis has
not yet been investigated. A total of 105 (80 male and 25 female) patients were included in our study. All patients underwent
elective percutaneous transluminal coronary angioplasty (PTCA) with bare metal stent implantation or direct stenting for one
coronary artery between September 2004 and January 2006. All patients were clinically followed for a period of 6 months, and
a control angiography was performed at the end of this period. The probrain natriuretic peptide (pro-BNP), high-sensitivity
Creactive protein (hs-CRP), and ADMA levels of the patients were evaluated before the procedure and 6 months afterwards. Biochemical
parameters and angiographic features were evaluated in order to determine if they could predict the development of restenosis
and MACE by using univariate and multivariate Cox regression analysis. The 65 (61.9%) patients (50 males and 15 females) who
had not developed restenosis were designated as Group 1. The 27 (25.7%) patients (21 males and 6 females) who had developed
restenosis were designated as Group 2. In terms of predicting the development of restenosis, the presence of diabetes mellitus
(hazard ratio [HR]: 2.78; confidence interval [CI]: 1.25–6.20; P = 0.01), type of lesion (HR: 1.89; CI: 1.01–3.55; P = 0.04), form of procedure (HR: 0.30; CI: 0.11–0.81; P = 0.01), and ADMA (HR: 4.08; CI: 1.73–9.62; P = 0.001) were found to be significant in univariate Cox regression analysis. In contrast, only the levels of ADMA were found
to be a significant predictor of restenosis in the multivariate Cox regression analysis (HR: 3.02; CI: 1.16–7.84; P = 0.02). The restenosis prediction of ADMA levels continued after excluding the patients with diabetes mellitus in the univariate
and multivariate Cox regression analysis (HR: 5.23; CI: 1.99–13.76; P = 0.001 and HR: 5.61; CI: 1.79–17.62; P = 0.003, respectively). Regarding the development of cardiac events, hs-CRP (HR: 1.03; CI: 1.00–1.06; P = 0.01) and ADMA (HR: 17.1; CI: 3.06–95.8; P = 0.001) were found to be significantly correlated with adverse cardiac events in univariate Cox regression analysis, whereas
only ADMA levels were significant in the multivariate Cox regression analysis (HR: 2.83; CI: 1.27–6.31; P = 0.01). The levels of ADMA obtained before the procedure predict the development of restenosis and MACE in patients who
underwent elective PTCA and bare metal stent procedures. 相似文献
106.
INTRODUCTION: A major problem in ocular therapeutics with classical formulations is the maintenance of an effective drug concentration at the site of action for a long period of time. Enhancement of ocular bioavailability with increased dose penetration and longer retention time at desired sites can be achieved by recent formulations. Chitosan stands out with its unique structural advantageous characteristics for different types of formulations like in situ gelling systems, micro- and nanoparticles, inserts, etc. AREAS COVERED: In this review, the authors focus on ocular therapeutics and the characteristics that make chitosan more acceptable in ocular applications. EXPERT OPINION: Chitosan seems to be one of the most promising polymeric carriers for both hydrophilic and lipophilic drugs for ocular application. 相似文献
107.
Kilic A Aktas Z Bedir O Gumral R Bulut Y Stratton C Tang YW Basustaoglu AC 《Annals of clinical and laboratory science》2011,41(2):161-166
Carbapenem resistance in Enterobacteriaceae isolates has been reported from Turkey and is most often mediated by OXA-48 type carbapenemases. We report the identification and characterization of four carbapenem-resistant isolates (three Klebsiella pneumoniae and one Escherichia coli) among 515 clinical Enterobacteriaceae isolates collected during a 7-month study period in Ankara, Turkey. The four isolates were recovered from blood and urine specimens in patients with varied clinical manifestations. They had distinct pulsed-field gel electrophoresis patterns and harbored a variety of β-lactamases including bla(TEM-1), bla(SHV-12) genes, bla(SHV-11), and/or bla(CTX-M-15). PCR and sequencing analysis revealed that the bla(OXA-48) gene was present in all four isolates. Our data indicated that the OXA-48-type carbapenemase was the only mechanism for carbapenem resistance in our hospital. 相似文献
108.
Selma Sönmez Ergün Yasemin Balsever Kural Özlem Su Ünal Egeli Nesimi Büyükbabani 《European journal of plastic surgery》2009,32(5):249-252
Actinomycosis is a rare disease caused by a microorganism of the normal oral flora. Infection is characterized by swollen
tissues and sinuses from which pus drains containing characteristic sulfur granules. Since actinomycosis is a tumorous infection
of skin and subcutaneous tissue, this chronic lesion can occasionally mimic neoplasia. A male patient is presented; he had
a tumor-like lesion of the left mental region that was initially diagnosed as tumor recurrence, but proved to be an Actinomyces infection on histopathologic examination. Excellent therapeutic response was obtained with a combination of antibiotic therapy,
surgical debridement, and mandibular curettage. Vestibuloplasty–commissuroplasty was also performed. 相似文献
109.
Dorothea Bornholdt Frank Oeffner Arne Knig Rudolf Happle Yasemin Alanay Jeffrey Ascherman Paul J. Benke María del Carmen Boente Ineke van der Burgt Nicolas Chassaing Ian Ellis Christina Raissa I. Francisco Patricia Della Giovanna Ben Hamel Cristina Has Kaatje Heinelt Andreas Janecke Wolfgang Kastrup Bart Loeys Ingo Lohrisch Carlo Marcelis Yasmin Mehraein Marie Eleanore O. Nicolas Dana Pagliarini Mauro Paradisi Annalisa Patrizi Maria Piccione Hildegunde Piza‐Katzer Bettina Prager Katrina Prescott Juliane Strien G. Eda Utine Marc S. Zeller Karl‐Heinz Grzeschik 《Human mutation》2009,30(5):E618-E628
110.
Simultaneous sudden infant death syndrome 总被引:1,自引:0,他引:1
Balci Y Tok M Kocaturk BK Yenilmez C Yirulmaz C 《Journal of Forensic and Legal Medicine》2007,14(2):87-91
The simultaneous sudden deaths of twins rarely occur and therefore it has received limited attention in the medical literature. When the deaths of the twins meet the defined criteria for sudden infant death syndrome (SIDS) independently and take place within the same 24 h range it can be called as simultaneous SIDS (SSIDS). The case(s): Twin girls (3.5-month-old) were found dead by their mother in their crib, both in supine position. The infants were identical twins and delivered at a hospital by cesarean section. Both infants were healthy and did not have any serious medical history. Two days prior to the incident, the twins had received the second dose of oral polio, DPT and the first dose of hepatitis B vaccines and they had fever on the first day of the vaccination and been given teaspoonful of acetaminophen. Death scene investigation, judicial investigation, parental assessment, macroscopic and microscopic autopsy findings and the toxicological analysis did not yield any specific cause of death. The case(s) were referred to a supreme board composed of multidisciplinary medical professionals at the Institute of Forensic Medicine, Ministry of Justice, in Istanbul. The Board decided that the available data was consistent with SIDS. These SIDS case(s) are presented because twin SIDS are rare and this is the first time that a simultaneous twin SIDS have been reported in Turkey. Simultaneous SIDS cases have many implications regarding definition, diagnosis and medico-legal approach. 相似文献