全文获取类型
收费全文 | 34590篇 |
免费 | 3594篇 |
国内免费 | 2504篇 |
专业分类
耳鼻咽喉 | 214篇 |
儿科学 | 476篇 |
妇产科学 | 391篇 |
基础医学 | 4223篇 |
口腔科学 | 621篇 |
临床医学 | 4466篇 |
内科学 | 5384篇 |
皮肤病学 | 314篇 |
神经病学 | 1553篇 |
特种医学 | 1151篇 |
外国民族医学 | 29篇 |
外科学 | 3739篇 |
综合类 | 6033篇 |
现状与发展 | 9篇 |
一般理论 | 3篇 |
预防医学 | 2407篇 |
眼科学 | 932篇 |
药学 | 3786篇 |
32篇 | |
中国医学 | 2006篇 |
肿瘤学 | 2919篇 |
出版年
2024年 | 169篇 |
2023年 | 700篇 |
2022年 | 1677篇 |
2021年 | 2100篇 |
2020年 | 1458篇 |
2019年 | 1250篇 |
2018年 | 1224篇 |
2017年 | 1143篇 |
2016年 | 1049篇 |
2015年 | 1564篇 |
2014年 | 1952篇 |
2013年 | 1757篇 |
2012年 | 2504篇 |
2011年 | 2811篇 |
2010年 | 1728篇 |
2009年 | 1369篇 |
2008年 | 1725篇 |
2007年 | 1820篇 |
2006年 | 1693篇 |
2005年 | 1614篇 |
2004年 | 1152篇 |
2003年 | 1113篇 |
2002年 | 974篇 |
2001年 | 787篇 |
2000年 | 762篇 |
1999年 | 767篇 |
1998年 | 453篇 |
1997年 | 467篇 |
1996年 | 353篇 |
1995年 | 341篇 |
1994年 | 331篇 |
1993年 | 177篇 |
1992年 | 225篇 |
1991年 | 227篇 |
1990年 | 238篇 |
1989年 | 182篇 |
1988年 | 152篇 |
1987年 | 120篇 |
1986年 | 124篇 |
1985年 | 94篇 |
1984年 | 70篇 |
1983年 | 39篇 |
1982年 | 27篇 |
1981年 | 22篇 |
1979年 | 20篇 |
1977年 | 16篇 |
1975年 | 14篇 |
1974年 | 19篇 |
1972年 | 13篇 |
1969年 | 13篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
目的 探讨脾结核的临床特点、诊断和治疗。方法 回顾性分析经临床、手术及病理证实的11例脾结核的临床特征。结果 11例患者中,男7例,女4例,平均年龄29岁。6例术后证实,5例经内科保守治疗后证实。多数患者表现为发热、消瘦、血沉增快、贫血、脾肿大,B超发现脾脏肿大11例,其中8例脾内多发占位,3例为孤立性占位;7例行CT检查,6例发现脾脏多发性大小不等的结节状低密度灶,1例为单发类圆形低密度影,边缘不清,增强扫描病灶内部无强化;6例患者伴后腹膜、脾门区等淋巴结肿大,5例患者伴其它脏器结核。结论 不明原因发热、消瘦、血沉增快、贫血、脾肿大为脾结核的主要临床表现,腹部B超和腹部CT能对脾结核作出较准确的判断,脾结核患者经正规治疗可治愈。 相似文献
102.
103.
104.
A total 37 patients with Crohn's disease who underwent intraoperative endoscopy during resection of the affected intestine were evaluated in this study. The average age of the patients at surgery was 23.2 years. The residual lesions in the remaining intestine identified by intraoperative endoscopy were classified according to their pathologic profiles into three groups: A, B and C. In group A, comprising patients with longitudinal ulcers and/or a cobblestone appearance, 10 of 12 patients had recurrence. In 5 of these 10, the residual lesions were exacerbated and 2 required a further operation. The remaining 5 patients showed recurrence at the site of previous anastomosis and 2 of these 5 required additional surgery.In group B, comprising patients with small ulcers, aphthoid ulcers, or scars, and group C, comprising patients with no residual lesions, recurrence was observed in 13 of 16, and 3 of 9 patients, respectively. The recurrent lesions were all found proximal to, or at the site of previous anastomosis. Additional operations were performed on 3 of the group B patients. The findings of this study revealed that recurrence requiring additional surgery is more frequent at the site of anastomosis, regardless of the endoscopic appearance of the residual lesions. 相似文献
105.
巢式聚合酶链反应检测脑脊液中单纯疱疹病毒DNA 总被引:1,自引:0,他引:1
应用巢式聚合酶链反应(PCR)检测患者脑脊液(CSF)中单纯疱疹病毒1型(HSV-1)DNA。23例经鞘内HSV-1特异性IgG抗体检测阳性的“HSV-1型性脑炎(HSE)”中19例PCR阳性,4例阴性患者病程均超过1个月。22例IgG阴性的“散发性脑炎”中7例PCR阳性,此7例皆于发病1周内检查CSF,其中2例取材于发病当日。1周后复查7例患者,CSF PCR仍为阳性,IgG皆阴性,提示PCR适用于HSE的早期诊断。 相似文献
106.
Adultacuteleukemia (AL)isoneofthemostcommonmalignanttumorsofhematology .Withtherecentprogressinchemotherapyandsupportivether apy ,theremissionandsurvivalrateinALhavebeenmarkedlyimproved .However ,drugresistanceandrelapsearestillimportantfactorsaffectinglongsur vivalofthese patients .Theabnormalregulationofcellcycleisanotherfactorthatcannotbeignoredex ceptformultipledrugresistance (MDR) .WedetectcyclinA ,multidrugresistantgene (mdrl) ,topoiso meraseⅡα(TopⅡα)andbcl 2inadultpatientswithA… 相似文献
107.
全身(全淋巴)照射后100例医源性急性放射病的临床分析 总被引:1,自引:1,他引:0
在造血干细胞移植治疗肿瘤过程中用全身照射(TBI)或全淋巴照射(TLI)预处理,研究受照不同剂量患者发生医源性急性放射病严重程度,治疗方法和造血恢复及相关合并症。方法100例患者(白血病91例,其他肿瘤9例)接受500~1000cGyTBI或TLI和超大剂量化疗作预处理。结果均发生医源性急性放射病,白细胞降至(0~0.15)×109/L,骨髓空虚,合并各种感染和出血。经造血干细胞移植,抗感染,应用GM-CSF或G-CSF积极支持治疗及保护隔离措施,92例造血恢复,8例死于不同感染和出血。结论造血干细胞的移植起主要治疗作用,不同造血因子用于治疗急性放射病,可能是一种有希望的方法 相似文献
108.
109.
回顾分析 65例脑脊液鼻漏病例。随访 3个月~ 1 0年 ,其中 2 6例经保守治疗痊愈 ,治愈率 40 %。 3 9例经保守治疗无效的患者 9例自动离院 ;行开颅手术修补 7例 ,其中 3例治愈 ;行鼻外入路修补术 3例 ,全部治愈 ;经鼻内镜修补术 2 0例 ,其中 1次手术治愈 1 9例 ,2次手术治愈 1例。经鼻内镜脑脊液鼻漏修补术的成功率为 1 0 0 % ,其中 1次修补成功率为 95 %。结果提示 :鼻内镜下脑脊液鼻漏修补术是外科治疗脑脊液鼻漏的首选术式 相似文献
110.
Li Hongyun Yao Yongming SHI Zhiguo Dong Ning Yu Yan Lu Lianrong Sheng Zhiyong 《感染、炎症、修复》2002,3(1):8-16
GTP-cyclohydrolase I (GTP-CHI) is the first and rate-limiting enzyme for the de novo biosynthesis of biopterin. The present study was to observe the effect of 2,4-diamino-6-hydroxy-pyrimidine (DAHP),an inhibtor of GTP-CHI, on the development of postburn Staphylococcus aureus sepsis. Methods: 56 male Wistar rats were randomly divided into four groups as follows: normal control group (n= 10), scald control group(n= 10),pos tburn sepsis group (n= 20) and DA HP treatment group (n= 16). In the scald control group, rats were subjected to a 20% total body surface area (TBSA) Ⅲ° scald injury, then sacrificed at 24 hrs. In the postburn sepsis group (n=20), rats were inflicted with 20% TBSA Ⅲ° scald followed by Staphylococcus aureus challenge, and they were further divided into 2 and 6 hrs groups. In the DAHP treatment group (n= 16), animals were intraperitoneally injected with a dose of 1g/kg DAHP prior to Staphylococcus aureus challenge, and then further divided into 2, 6 hrs groups. Tissue samples from liver, kidneys, lungs and heart were collected to determine GTP-CHI, inducible nitric oxide synthase (iNOS) and tumor necrosis factor-α (TNF-α) mRNA expression. Meanwhile, biopterin and nitric oxide (NO) levels in these tissues were also measured. Results: After the scald injury followed by Staphylococcus aureus challenge, GTP-CHI mRNA expression and biopterin levels significantly elevated in various tissues such as liver, heart, kidneys and lungs, so did the values of iNOS mRNA expression and NO formation (P<0.01). Pretreatment with DAHP could significantly reduce GTP-CHI/biopterin induction (P<0. 05~0. 01), and the up-regulation of iNOS/NO was also suppressed. Furthermore, DAHP administration could also inhibit the gene expression of TNF-α. 2 hrs after septic challenge, TNF-α mRNA expression in liver, kidneys and lungs in DAHP-treated group were 35.7%, 37.3% and 33.0% of those in postburn septic group, respectively. Additionally, in animals without DAHP treatment, the 6-hour mortality was 55.6% (20/36), while it was only 25.0% in DAHP-treated animals (4/16, P=0. 08). Conclusions: Early treatment with DAHP might be a potential strategy to prevent the development of postburn Staphylococcal sepsis, which appears to be associated with down-regulation of biopterin and NO formation by DAHP. 相似文献