阿莫西林颗粒治疗小儿感染性疾病1983例

目的:评价阿莫西林颗粒(再林)对小儿感染性疾病的疗效及安全性.方法:采用随机对照开放试验,试验组1 983例,口服阿莫西林颗粒40～80mg·kg-1,tid;对照组693例,口服头孢拉定干混悬剂6.25～12.5mg·kg-1,tid,疗程7～14d.结果:试验组痊愈率和总有效率分别为69.49%和91.88%,优于对照组的35.93%和60.46%(P＜0.05);细菌清除率试验组96.67%,对照组83.33%,2组比较差异有极显著性(P＜0.01);不良反应发生率试验组1.46%,对照组4.91%,差异有极显著性(P＜0.01).结论:阿莫西林颗粒治疗儿科感染性疾病疗效较好,在服药前需详细询问青霉素及其他药物过敏史,首剂应在医护人员密切观察下服药.     

淀粉对转移因子胶囊质量控制方法的影响

目的考查淀粉对转移因子胶囊在251与280nm波长处的吸光度的比值(纯度检查)的影响。方法选取不同的淀粉并对比2种不同的样品处理方法对测定结果的影响。结果淀粉的存在确实能使转移因子胶囊在251与280nm波长处的吸光度的比值降低,且造成结果不稳定。结论测定含淀粉转移因子胶囊的样品时,宜先将样品制成较高质量浓度,滤去不溶或微溶辅料后,稀释至适宜的质量浓度测定,以尽可能减少辅料的干扰。     

路由监控分析系统的设计和实现

BGP和OSPF是目前网络中普遍使用的域间和域内路由协议,路由协议的运行状态直接影响网络性能.本文设计和实现了一个通用的路由监控分析系统,能实时收集路由信息,自动生成域间域内拓扑,提供历史拓扑信息的浏览和重放、拓扑图的比较、路由信息的解析和统计等功能,并能够分析路由收敛和稳定性,从而辅助网管人员掌握网络路由系统实时运行状况,做出相应的管理决策.     

Application of deliberate hypotension with nitroglycerin and esmolol in patients undergoing laparocholisystectomy

目的 探讨硝酸甘油复合艾司洛尔控制性降压在腹腔镜胆囊切除术(LC)中应用的效果.方法 66例LC患者术中MAP超过100 mm Hg,随机均分为A组(硝酸甘油降压)、B组(硝酸甘油+艾司洛尔降压)和C组(不行降压).三组均采用气管内插管全身麻醉.记录气腹前(T1)、气腹后5 min(T2)、15 min(T3)、30 min(T4)以及解除气腹后5 min(T5) MAP、HR和心率收缩压乘积(RPP).结果 C组气腹后各时间点MAP、HR、RPP均显著高于气腹前(P＜0.01);A组在降压期间各时间点的HR及RPP均较降压前明显升高(P＜0.01);B组降压期的HR及RPP较降压前及A、C两组显著降低(P＜0.01).结论 硝酸甘油复合艾司洛尔控制性降压较单用硝酸甘油降压更能有效降低患者心肌耗氧量、提高围术期的安全性.     

中西医结合治疗急性脑卒中后抑郁症临床观察

脑卒中后抑郁(PSD)是卒中急性期最常见的并发症之一,可明显影响患者康复锻炼的主动性和神经功能的恢复,增加卒中患者的病死率[1]。并成为阻碍患者神经功能及日常生活能力恢复的重要因素,使患者的生存质量下降,因此备受神经内科、心理科和康复科医生的关注。2005年3月~2007年3月     

Association of Gut Microbiota Enterotypes with Blood Trace Elements in Women with Infertility

Infertility is defined as failure to achieve pregnancy within 12 months of unprotected intercourse in women. Trace elements, a kind of micronutrient that is very important to female reproductive function, are affected by intestinal absorption, which is regulated by gut microbiota. Enterotype is the classification of an intestinal microbiome based on its characteristics. Whether or not Prevotella-enterotype and Bacteroides-enterotype are associated with blood trace elements among infertile women remains unclear. The study aimed to explore the relationship between five main whole blood trace elements and these two enterotypes in women with infertility. This retrospective cross-sectional study recruited 651 Chinese women. Whole blood copper, zinc, calcium, magnesium, and iron levels were measured. Quantitative real-time PCR was performed on all fecal samples. Patients were categorized according to whole blood trace elements (low levels group, <5th percentile; normal levels group, 5th‒95th percentile; high levels group, >95th percentile). There were no significant differences in trace elements between the two enterotypes within the control population, while in infertile participants, copper (P = 0.033), zinc (P < 0.001), magnesium (P < 0.001), and iron (P < 0.001) in Prevotella-enterotype was significantly lower than in Bacteroides-enterotype. The Chi-square test showed that only the iron group had a significant difference in the two enterotypes (P = 0.001). Among infertile patients, Prevotella-enterotype (Log(P/B) > −0.27) predicted the low levels of whole blood iron in the obesity population (AUC = 0.894; P = 0.042). For the high levels of iron, Bacteroides-enterotype (Log(P/B) <−2.76) had a predictive power in the lean/normal group (AUC = 0.648; P = 0.041) and Log(P/B) <−3.99 in the overweight group (AUC = 0.863; P = 0.013). We can infer that these two enterotypes may have an effect on the iron metabolism in patients with infertility, highlighting the importance of further research into the interaction between enterotypes and trace elements in reproductive function.     

细胞角蛋白19-2G2和细胞角蛋白19片段抗原在非小细胞肺癌化疗疗效评估中的价值

目的 评价血清肿瘤标志物细胞角蛋白19-2G2(CK-2G2)和细胞角蛋白19片段抗原(Cyfra21-1)在非小细胞肺癌(NSCLC)疗效评估中的临床应用价值.方法 应用化学发光法检测124例NSCLC(腺癌74例,鳞癌50例)患者化疗前、化疗1个周期和2个周期血清中CK-2G2和Cyfra21-1的水平.经正态性检验,CK-2G2和Cyfra21-1水平为偏态分布资料,以M(QR)表示,组间和化疗前后比较采用秩和检验.结果 腺癌和鳞癌患者化疗1个周期后CK-2G2和Cyfra21-1的水平明显下降[腺癌患者分别为0.77(0.03 ～ 55.85)U/L比1.86(0.02 ～ 55.60)U/L、1.88(0.15 ～ 18.65)μg/L比2.35(0.14 ～22.32)μg/L;鳞癌患者分别为1.67(0.04～218.60)U/L比4.75(0.05 ～ 226.30)U/L、2.12(0.12 ～ 20.65)μg/L比4.07(0.11～40.21)μg/L].疾病进展患者(9例)化疗1个周期后CK-2G2和Cyfra21-1的水平明显升高(P＜0.01);疾病稳定患者(49例)和部分缓解患者(66例)化疗1个周期后CK-2G2的水平明显下降(P＜0.01);化疗2个周期后与化疗1个周期后比较,NSCLC患者CK-2G2和Cyfa21-1的水平无明显变化(P＞0.05).结论 肿瘤标志物CK-2G2和Cyfra21-1可作为NSCLC化疗早期疗效评价参考指标.     

青刺果多糖的提取及含量测定

目的 研究青刺果多糖的提取工艺并测定多糖的含量.方法 采用正交实验,进行水提醇沉法的优选;以葡萄糖标准液绘制标准曲线,用苯酚-硫酸,紫外分光光度法于490 nm波长处测定青刺果多糖的含量.结果 多糖的最佳提取条件为100℃.料液比为1:20,提取时间8 h,乙醇终浓度为85%.测定青刺果多糖含量最高达36.44%.结论 最佳提取条件得率高,测定方法准确,对青刺果多糖含量的测定获得较满意结果.