全文获取类型
收费全文 | 44097篇 |
免费 | 4682篇 |
国内免费 | 3410篇 |
专业分类
耳鼻咽喉 | 461篇 |
儿科学 | 575篇 |
妇产科学 | 598篇 |
基础医学 | 4490篇 |
口腔科学 | 736篇 |
临床医学 | 5632篇 |
内科学 | 6136篇 |
皮肤病学 | 475篇 |
神经病学 | 1847篇 |
特种医学 | 1617篇 |
外国民族医学 | 15篇 |
外科学 | 4310篇 |
综合类 | 8848篇 |
现状与发展 | 18篇 |
一般理论 | 5篇 |
预防医学 | 3966篇 |
眼科学 | 1133篇 |
药学 | 4918篇 |
50篇 | |
中国医学 | 2815篇 |
肿瘤学 | 3544篇 |
出版年
2024年 | 157篇 |
2023年 | 591篇 |
2022年 | 1598篇 |
2021年 | 2093篇 |
2020年 | 1621篇 |
2019年 | 1423篇 |
2018年 | 1464篇 |
2017年 | 1512篇 |
2016年 | 1337篇 |
2015年 | 2013篇 |
2014年 | 2479篇 |
2013年 | 2566篇 |
2012年 | 3441篇 |
2011年 | 3596篇 |
2010年 | 2657篇 |
2009年 | 2282篇 |
2008年 | 2551篇 |
2007年 | 2561篇 |
2006年 | 2352篇 |
2005年 | 2164篇 |
2004年 | 1869篇 |
2003年 | 2099篇 |
2002年 | 1791篇 |
2001年 | 1408篇 |
2000年 | 978篇 |
1999年 | 787篇 |
1998年 | 453篇 |
1997年 | 447篇 |
1996年 | 277篇 |
1995年 | 282篇 |
1994年 | 249篇 |
1993年 | 160篇 |
1992年 | 168篇 |
1991年 | 155篇 |
1990年 | 123篇 |
1989年 | 99篇 |
1988年 | 73篇 |
1987年 | 62篇 |
1986年 | 58篇 |
1985年 | 49篇 |
1984年 | 22篇 |
1983年 | 25篇 |
1982年 | 13篇 |
1981年 | 13篇 |
1979年 | 12篇 |
1977年 | 10篇 |
1976年 | 7篇 |
1974年 | 7篇 |
1973年 | 8篇 |
1972年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
妊娠胆汁淤积症(ICP)是一种在妊娠期出现的以皮肤搔痒和黄疸为特征的较常见的并发症, 易导致早产、胎儿窘迫、死胎、新生儿死亡及产后出血等,严重影响围产儿安 全。思美泰是一种治疗ICP的新药,疗效显著。现将1998年10月~2000年10月收治的60例ICP 随机应用思美泰和门冬氨酸钾镁治疗,报道如下:
1 资料和方法
1.1 临床资料来源
60例ICP均为本院住院病人,年龄22~35岁,平均26.7岁,初产妇52人,经产妇8人,均有皮 肤搔痒和肝功能异常,肝类病原学指标全部阴性,并排除妊高征肝损,急性脂肪肝及药物性 肝炎。随机分为2组,2组病例年龄、病情、肝功能损害程度和孕周无显著差异。
1.2 治疗方案
治疗组采用德国基诺药厂生产的思美泰注射液1g,由稀释液溶解加入5%葡萄糖注射液250ml 中静滴,每日1次,持续4周。对照组采用杭州民生药厂生产的门冬氨酸钾镁注射液30ml加入 5%葡萄糖注射液250ml中静滴,每日1次,持续4周。2组基础药物相同,包括Vitc、复方益 肝灵及中药茵陈汤。
1.3 疗效判断
疗效判断标准分为3组:①显效:用药后患者症状、体征明显改善,生化(谷丙转氨酶、总 胆红素、总胆汁酸)恢复正常或降至治疗前基础的50%以上;②有效:症状体征改善,生化指 标有下降,但未降至基础的50%;③无效:症状体征及生化指标没有改善或有加重者。显效 和有效合计称为有效病例,据此计算有效率。 相似文献
62.
目的 :探讨肾衰透析患者拔牙的安全性。 方法 :对 42例肾衰血透患者行 98次拔牙手术 ,共拔除患牙 12 2颗 ,术前采取全口洁治、服用抗生素、控制血压等措施 ,术后加强局部止血处理 ,预防出血、感染及心血管系统等并发症的发生。 结果 :透析组术后出血 44次 ,拔牙创口血块充盈不良或脱落 2 7次 ;对照组分别为 4和 5次 (94次手术 ,P<0 .0 5 )。拔牙创口定期观察 1个月 ,均愈合良好。 结论 :慢性肾衰患者通过透析 ,尿毒症得到控制和改善时 ,在作好围拔牙期处理的情况下 ,行拔牙手术是安全可行的 相似文献
63.
新型免疫抑制剂霉酚酸酯治疗狼疮性肾炎 总被引:23,自引:0,他引:23
目的观察新型免疫抑制剂霉酚酸酯(M.MF)治疗狼疮性肾炎的临床疗效和安全性。方法经肾活检证实的20例狼疮性肾炎,给予糖皮质激素联合MMF治疗。MMF初始剂量1.0~1.5g/d,治疗时间321个月,平均(10.9±6.2)个月。结果MMF治疗后24h尿蛋白定量从治疗前的平均5.55g下降至1.54g;d清白蛋白治疗前平均26.87g升至39g;6/8例肾功能不全患者3个月内Scr恢复正常;d清自身抗体产生明显减少,补体上升,其中ANA转阴率3个月达63%,6个月达81%;抗ds-DNA由治疗前23.77IU/ml下降至9.19IU/ml;2例重复活检,肾小球活动性病变明显减轻。MMF治疗的不良反应较少,偶有白细胞减少、感染、带状疱疹等。结论MMF对于各型狼疮性肾炎,尤其是Ⅳ型重症狼疮,经传统治疗无效者均有较好疗效,且长期应用不良反应少。 相似文献
64.
65.
Jingqi Zhang Shibo Zhu Liyu Zhang Wen Fu Jinhua Hu Zhao Zhang Wei Jia 《Translational andrology and urology》2021,10(5):2084
BackgroundThe effect of caudal block (CB) on the incidence of urethroplasty complications in hypospadias repair remains controversial. The evidence is conflicting, and some confounding bias issues need to be addressed. We sought to study a more homogenous group of distal hypospadias patients undergoing primary tubularized incised plate (TIP) repair by a senior pediatric urology surgeon in the past 2 years to examine the relationship between urethroplasty complications and the use of CB.MethodsWe reviewed our database to identify consecutive patients who had undergone hypospadias repairs by a senior director surgeon at our Center between January 2018 and November 2020. To be eligible to participate in the study, patients had to meet the following inclusion criteria: (I) have distal hypospadias; (II) have undergone a primary TIP repair; and (III) have attended follow-up appointments for a minimum period of 6 months. The primary outcome was the development of urethroplasty complications during the follow-up period. The principal variable of interest was whether or not CB was used perioperatively. The patients were categorized into a CB group (general anesthesia combined with CB) or a control group (general anesthesia only). Other potential risk factors were analyzed, including patient age at operation, patient weight, glans width, and the length of the urethral plate defect.ResultsThirty (12.2%) of the distal patients developed postoperative surgical complications. The postoperative surgical complication rates were similar between the different anesthesia groups. Weight, the length of the urethral plate length, and glans width did not contribute to the risk. Age was the only independent risk factor for postoperative surgical complications, and the complication rates increased in older patients.ConclusionsOur data from consecutive TIP repairs in distal hypospadias patients indicated no association between the use of CB anesthesia and the postoperative urethroplasty complication rate. Patients who were older in age when they underwent surgery had a higher risk of complications. 相似文献
66.
Wen MC Wei CH Hu ZQ Srivastava K Ko J Xi ST Mu DZ Du JB Li GH Wallenstein S Sampson H Kattan M Li XM 《The Journal of allergy and clinical immunology》2005,116(3):517-524
BACKGROUND: Chinese herbal medicine has a long history of human use. A novel herbal formula, anti-asthma herbal medicine intervention (ASHMI), has been shown to be an effective therapy in a murine model of allergic asthma. OBJECTIVE: This study was undertaken to compare the efficacy, safety, and immunomodulatory effects of ASHMI treatment in patients with moderate-severe, persistent asthma with prednisone therapy. METHODS: In a double-blind trial, 91 subjects underwent randomization. Forty-five subjects received oral ASHMI capsules and prednisone placebo tablets (ASHMI group) and 46 subjects received oral prednisone tablets and ASHMI placebo capsules (prednisone group) for 4 weeks. Spirometry measurements; symptom scores; side effects; and serum cortisol, cytokine, and IgE levels were evaluated before and after treatment. RESULTS: Posttreatment lung function was significantly improved in both groups as shown by increased FEV(1) and peak expiratory flow findings (P<.001). The improvement was slightly but significantly greater in the prednisone group (P<.05). Clinical symptom scores, use of beta(2)-bronchodilators, and serum IgE levels were reduced significantly, and to a similar degree in both groups (P<.001). T(H)2 cytokine levels were significantly reduced in both treated groups (P<.001) and were lower in the prednisone-treated group (P<.05). Serum IFN-gamma and cortisol levels were significantly decreased in the prednisone group (P<.001) but significantly increased in the ASHMI group (P<.001). No severe side effects were observed in either group. CONCLUSION: Anti-asthma herbal medicine intervention appears to be a safe and effective alternative medicine for treating asthma. In contrast with prednisone, ASHMI had no adverse effect on adrenal function and had a beneficial effect on T(H)1 and T(H)2 balance. 相似文献
67.
68.
三味中药配伍应用对改善烫伤小鼠受损免疫功能的作用 总被引:1,自引:0,他引:1
目的 观察对烫伤小鼠受损免疫功能具有调理作用的单味中草药 ,经过配伍应用后的协同作用。方法 采用 1 .0 3 4× 1 0 5 Pa的蒸气烫伤 1 0s ,烫伤面积 1 6% ,深度为Ⅲ度的致伤模型烫伤动物。通过观察MΦ的吞噬功能、枯否细胞清除能力、MΦ抗原提呈功能、血清TNF量、淋巴细胞增殖反应及IL 2产生能力、小鼠抗体产生能力、PMNH2 O2 释放量及PMN溶菌酶释放量、血清补体的趋化作用和聚集作用等指标 ,籍以了解单味中药与配伍中药对烧 (烫 )伤小鼠受损免疫功能的调理作用。结果 单味中药三七(PP) ,金银花 (LJ)和虎杖 (PC)对小鼠受损免疫功能有一定的改善作用。PC +LJ、PP +PC、PP +LJ等二味配伍的中药 ,除少数指标外 ,均比单味药的作用好。而PP +LJ+PC三味配伍药的调理作用 ,比单味药和二味配伍药的调理作用更佳。结论 单味中药经配伍应用后对烧 (烫 )伤小鼠严重受损的免疫系统功能 ,具有比单味药更好的协同调理作用。 相似文献
69.
70.
以电化学方法合成了聚合漆酚(EPU),并用EPU与二异丙氧基锌作用生成漆酚金属螯合物「EPU-Zn(Ⅱ)」,采用原子发射光谱(AES)、FT-IR、DMTA、TG-DTA和XPS等对其进行表征,探讨其结构与性质。证明了螯合物中存在着因Zn(Ⅱ)和EPU配位作用而引起的交联,故难溶于绝大多数的有机溶剂,玻璃化转变温度和耐热性能的提高。 相似文献