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91.
窥镜下激光治疗前列腺增生症   总被引:2,自引:0,他引:2  
Li Q  Liu J  Xu X  Hou Z  Zhuang H  Xue J  Wang J  Cao Y 《中华外科杂志》1999,37(6):361-363
目的 评价经尿道激光前列腺切除术(TULP)的疗效及其与前列腺大小的关系。方法 回顾分析了1988年至1998年10年,采用TULP治疗的469例前列腺增生症患者对手术技术、手术前后的症关改善情况进行比较,并对233例符合条件的患者TULP手术效果与前列腺大小的相关性进行了研究。结果 469例患者前列腺症状评分(IPSS)平均值由术前的26.7降到术后的14.2;最大尿流率平均值由6.2ml/s上  相似文献   
92.
OBJECTIVES: Airborne exposure to polycyclic aromatic hydrocarbons (PAH) in the potroom of an aluminum reduction plant was studied in relation to genotoxic or mutagenic effects, and the possibility of host genotypes of different metabolizing enzymes modifying associations between PAH exposure and genotoxic or mutagenic response was assessed. SUBJECTS AND METHODS: Ninety-eight male potroom workers and 55 male unexposed blue-collar workers constituted the study population. Micronuclei in CD4+ and CD8+ lymphocytes, DNA (deoxyribonucleic acid) single-strand breaks, hypoxanthine guanine phosphoribosyl transferase (HPRT) mutation frequency, and genotype for cytochrome P-4501A1, glutathione transferases M1, T1 and P1, and microsomal epoxide hydrolase were analyzed using peripheral mononuclear cells. Urine samples were collected for the analysis of 8-hydroxydeoxyguanosine. RESULTS: Micronuclei in peripheral CD4+ and CD8+ lymphocytes, DNA single-strand breaks, HPRT mutation frequency, and 8-hydroxydeoxyguanosine in urine did not differ between the potroom workers and the unexposed referents. With the exception of an observed exposure-response relationship for potroom workers with Tyr/Tyr genotype for microsomal epoxide hydrolase, between airborne PAH and CD8+ micronuclei, no correlations were found between any of the genotoxicity biomarkers and any of the exposure measures (airborne particulate PAH, airborne gas phase PAH, length of employment in the potroom, 1-hydroxypyrene in urine, or PAH-DNA adducts in peripheral lymphocytes), also when genotypes for biotransforamtion enzymes were considered. CONCLUSIONS: The results indicate that the employed biomarkers of mutagenic or genotoxic effects are not appropriate for surveillance studies of potroom workers exposed to current airborne levels of PAH. The significance of the correlation between airborne PAH and CD8+ micronuclei in Tyr/Tyr genotype subjects should be evaluated.  相似文献   
93.
目的探讨治疗臁疮的有效方药;方法应用白行研制的愈溃膏,采用外敷的方法,治疗臁疮80例,同期常规治疗45例作为对照;结果应用愈溃膏治疗80例患均取得较好效果,明显优于对照组;结论愈溃膏对于臁疮有较好疗效。  相似文献   
94.
目的:探讨腹腔镜下子宫切除的手术方法。方法:选择子宫肌瘤31例及子宫腺肌症3例为手术对象。8例作子宫全切除,26例为子宫次全切除。以电刀凝切方法分离子宫旁韧带,子宫的游离可达Ⅲ~Ⅳ级。结果:31例顺利完成手术,手术成功率91.2%。未发生邻近脏器损伤。结论:腹腔镜子宫切除手术创伤小,但难度较常规开放手术大,预防术中出血与邻近脏器损伤是手术成功的关键。  相似文献   
95.
PURPOSE: To determine whether dopamine receptor stimulation regulates Na,K-ATPase-mediated ion transport in cultured nonpigmented ciliary epithelium (NPE). METHODS: Using a rabbit NPE cell line, active Na-K transport activity was determined by measuring ouabain-sensitive potassium (86Rb) uptake in cell monolayers. Western blot analysis of membrane material obtained from cell homogenates was conducted to examine tyrosine phosphorylation of membrane proteins. RESULTS: Ouabain-sensitive potassium (86Rb) uptake was inhibited in the presence of either dopamine or the D1-selective agonist SKF82958. The response was suppressed by SCH23390, a D1 antagonist, but not by sulpiride, a D2-selective antagonist. Quinpirole, a D2-selective agonist, did not cause inhibition of ouabain-sensitive potassium (86Rb) uptake. Cyclic adenosine monophosphate (cAMP) was detectably increased in SKF82958-treated cells, although the concentration of SKF required to elevate cell cAMP was higher than the concentration needed to inhibit ouabain-sensitive potassium (86Rb) uptake. The protein kinase A inhibitor H89 prevented the 86Rb uptake response to SKF82958. Genistein, an inhibitor of tyrosine kinases, also prevented the 86Rb uptake response to SKF82958. Membrane material isolated from cells exposed to SKF82958 showed an increase in the density of several phosphotyrosine bands. These changes in phosphotyrosine immunoblot density were not observed in material isolated from cells that received either genistein or SCH23390 before SKF82958 treatment. CONCLUSIONS: The results of this study suggest D1 agonists cause a reduction of Na,K-ATPase-mediated ion transport by a mechanism that could involve a tyrosine kinase step.  相似文献   
96.
本文调查分析1所大型综合性医院1989-1994年麻醉性镇痛药使用情况,平均年消耗量为29645±s5591DDDs。年开支金额逐年增加,1994年为1990年的440%。内科用量占全院的55.3%,二氢埃托啡片1991年猛增至10万片以上,卫生部下达文件后下降。门诊麻醉镇痛药用量占4.9%,其处方量占总处方量的0.35%。主要使用单位是急诊科,占70.2%。男女患者比为2.4:1;26-45aa组占45.6%。药物利用指数0.29-0.70,使用不当者主要是二氢埃托啡,发现2人发生依赖性。43名癌痛患者很少按“三阶梯止痛疗法”给药。根据存在的问题,本文提出相应的建议。  相似文献   
97.
This paper report,s the iodine metabolism and pituitary-thyroid axis function among the inhabitants of an untreated endemic goiter region in the southeast.ern part (Heba commune) of Guizhou province. The results of the investigation showed that the urine iodine excretion of the inhabi- tants in the untreated endemic goiter region was lower than that of those in the normal non- endemic region, a rural commune of Guiyang city and an iodized salt treated endemic region, Shilong commune. The urine iodine excretion was low not only among the goiter patients and cretins but also among the nongoitrous adults and children. Same was with the 24 hr thyroid .131I uptake figures which were higher than normal among the goiter patients and cretins as well as nongoitrous adults and children in Heba commune. It is concluded that in the endemic goiter region, the goiter patients and cretins as well as the nongoitrous adults and children are suffering from iodine deficiency. Studies of pituitary thyroid axis function of the inhabitants in the untreated endemic goiter region, Heba commune, showed basically normal values for serum T3, definitely low values for serum T4 and markedly elevated values for se- rum TSH. The relation_ship between low serum T4 and elevated serum TSH was frequently ob- served among the cretins and the goiter ;patients although myxedema was rarely manifested. Thus hormonal hypothyroidism was not un- common among the inhabitants of Heba com- mune and the term "euthyroidism" should be used with discretion.  相似文献   
98.
目的:观察抗组织胺新药诺司咪唑对小鼠的致畸作用。方法:在小鼠妊娠致畸敏感期(6—15天)分别连续灌胃给予诺司咪唑29.2、58.4和116.8mg/kg,于妊娠第18天解剖动物并记录孕鼠体重、活胎数、死胎数、吸收胎数、胎仔体重、身长、尾长、胎盘重及外观、骨骼和内脏畸形胎仔数。结果:诺司咪唑使孕鼠体重生长缓慢,但对生殖能力无明显影响,高剂量组对胎仔体重、身长和尾长有一定影响,各组均未见胎仔有外观、骨骼和内脏畸形。结论:诺司咪唑对胎仔发育有一定影响,但无致畸作用。  相似文献   
99.
抗癌胶囊对实验性肿瘤的治疗及对化疗减毒作用研究   总被引:4,自引:1,他引:4  
王艳  王英  侯宇成  吴玉波 《中国药师》2003,6(3):133-135
目的:研究抗癌胶囊对小鼠移植肿瘤S180,H22,Lewis的抑瘤作用及对化疗药所致小鼠免疫功能抑制的保护作用。方法:按照抗癌药物筛选规程进行体内抑瘤实验:采用氟尿嘧啶(FU)制备免疫功能低下模型,测定抗癌胶囊对小鼠白细胞计数、免疫器官重量、腹腔巨噬细胞吞噬功能和NK细胞的影响。结果:抗癌胶囊对小鼠移植肿瘤S180,H22,Lewis均有不同的抑瘤作用,其中高剂量组抑瘤效果最佳,并对小鼠体重生长无明显影响。抗癌胶囊还有明显拮抗FU所致白细胞下降,胸腺、脾脏萎缩,腹腔巨噬细胞功能降低和NK细胞减少等毒副作用。结论:抗癌胶囊具有明显的抗肿瘤作用。  相似文献   
100.
香菇多糖对巨噬细胞一氧化氮和一氧化氮合酶活性的影响   总被引:2,自引:0,他引:2  
目的研究香菇多糖(LTN)诱导巨噬细胞的一氧化氮(NO)生成和一氧化氮合酶(iNOS)的活性,探讨LTN的免疫调节作用机理.方法采用Griess反应和荧光法测定不同剂量的LTN作用小鼠腹腔巨噬细胞后NO的生成量和iNOS活性.观察mRNA转录抑制剂、蛋白质合成抑制剂和iNOS抑制剂对巨噬细胞NO的生成和iNOS活性的影响.结果LTN能使小鼠腹腔巨噬细胞NO生成增加,iNOS活性增高,并呈作用剂量依赖关系.3种抑制剂均能抑制LTN诱导的小鼠腹腔巨噬细胞N0的生成和iNOS活性.结论LTN能刺激小鼠腹腔巨噬细胞提高iNOS活性和NO的生成.提示LTN的免疫调节作用机制可能与LTN刺激巨噬细胞NO生成有关.  相似文献   
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