全文获取类型
收费全文 | 88342篇 |
免费 | 7100篇 |
国内免费 | 3918篇 |
专业分类
耳鼻咽喉 | 911篇 |
儿科学 | 1033篇 |
妇产科学 | 1429篇 |
基础医学 | 11816篇 |
口腔科学 | 1971篇 |
临床医学 | 9631篇 |
内科学 | 14579篇 |
皮肤病学 | 1416篇 |
神经病学 | 5226篇 |
特种医学 | 2702篇 |
外国民族医学 | 25篇 |
外科学 | 10171篇 |
综合类 | 11543篇 |
现状与发展 | 7篇 |
一般理论 | 9篇 |
预防医学 | 5986篇 |
眼科学 | 2207篇 |
药学 | 8718篇 |
45篇 | |
中国医学 | 2847篇 |
肿瘤学 | 7088篇 |
出版年
2024年 | 117篇 |
2023年 | 665篇 |
2022年 | 1632篇 |
2021年 | 2323篇 |
2020年 | 1781篇 |
2019年 | 1679篇 |
2018年 | 2182篇 |
2017年 | 1966篇 |
2016年 | 1841篇 |
2015年 | 2623篇 |
2014年 | 3462篇 |
2013年 | 3703篇 |
2012年 | 5141篇 |
2011年 | 5313篇 |
2010年 | 3687篇 |
2009年 | 3207篇 |
2008年 | 4061篇 |
2007年 | 4113篇 |
2006年 | 3894篇 |
2005年 | 3233篇 |
2004年 | 2435篇 |
2003年 | 2313篇 |
2002年 | 2100篇 |
2001年 | 5248篇 |
2000年 | 5150篇 |
1999年 | 4506篇 |
1998年 | 1730篇 |
1997年 | 1407篇 |
1996年 | 878篇 |
1995年 | 752篇 |
1994年 | 673篇 |
1993年 | 532篇 |
1992年 | 2072篇 |
1991年 | 1797篇 |
1990年 | 1636篇 |
1989年 | 1553篇 |
1988年 | 1373篇 |
1987年 | 1260篇 |
1986年 | 1112篇 |
1985年 | 939篇 |
1984年 | 617篇 |
1983年 | 482篇 |
1982年 | 260篇 |
1981年 | 192篇 |
1980年 | 145篇 |
1979年 | 288篇 |
1978年 | 77篇 |
1974年 | 75篇 |
1973年 | 95篇 |
1972年 | 71篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
O Jegaden X Martin F Canton A Gelet J M Dubernard 《Journal des maladies vasculaires》1987,12(4):315-318
Sixteen patients underwent surgical treatment for severe renovascular hypertension with rapidly progressive renal failure. These patients were assessed preoperatively with the measurement of serum creatinine and blood-urea levels (means 271 +/- 204 mumol/l and 15.6 +/- 10.3 mmol/l respectively), and renal clearances. 5 patients underwent aorto-renal bypass (bilateral in one case) and 11 patients were treated by autotransplantation of the kidney. Operative mortality was 6.2%. Early results were assessed at 1 and 6 months postoperatively. Renal function was normal in 8 patients, improved in 5 (p less than 0.05), unchanged in 1 and worse in 1 by aorto-renal bypass thrombosis. At long-term with a minimum follow-up of 12 months (mean 31 +/- 12 months), the initial improvement in renal function remained steady in 12 patients whilst 1 patient has gone on to hemodialysis. At middle and long-term, 81% of the patients were normotensive without medication or had improved blood pressure (p less than 0.001). These good results confirm the reversibility of renal ischemic lesions and support an aggressive attitude towards the use of revascularization in the surgical treatment of such patients with renovascular hypertension and renal failure. 相似文献
72.
The cardiotoxic effects of hydralazine and prenalterol, given alone and in combination, were assessed in rats and rabbits. Acute myocardial necrosis was induced by a single administration of each drug alone in rats. However, the incidence and severity of lesions were markedly enhanced when both drugs were given in combination. Rats that received the same treatment for 10 consecutive days showed minimal or no acute necrosis, demonstrating the development of a resistance to further cardiotoxic effects of the drugs. Rabbits showed only minimal lesions when either drug was used alone and no enhancement of lesions when they were given in combination. From these data, it is concluded that the possibility of a cardiotoxic interaction exists when these drugs are used in combination and that the heavy rat (500-600 g) is a more sensitive model than the rabbit for studies of this nature. 相似文献
73.
74.
75.
目的 探讨腹腔镜手术结合术中内窥镜治疗结直肠良性病变的方法和临床意义.方法 回顾性分析2004年6月至2006年12月13例结直肠良性病变以腹腔镜结合术中内窥镜治疗的患者的临床资料.结果 结肠多发性息肉1例,息肉3枚,直径1.5 cm~2.5 cm,乙状结肠、降结肠和直肠上段单发息肉或腺瘤11例,病变直径1.5 cm~3.0 cm,降结肠憩室并出血1例,直径1 cm,全部患者均在腹腔镜下结合术中内窥镜定位,经腹壁小切口找到定位处肠管切开后完整切除病变或缝扎憩室.无术后并发症.结论 腹腔镜结合术中内窥镜治疗结直肠良性病变定位准确、创伤小、安全有效,适合结直肠大部分位置良性疾病的治疗. 相似文献
76.
77.
Chai Ben-Fu柴本甫Shanghai Institute of Traunatology Orthopedics ShanghaiTang Xue-ming汤雪明Shanghai Second Medical College Shanghai 《中华医学杂志(英文版)》1986,99(2):126-132
Transmission electron microscopic investigation
of standardized fractures of radii in 50 rabbits re
vealed that fibroblasts took part in the formation of
bony callus. The osteogenetic role played by the
fibroblasts can be categorized into the following 5
aspects: a. Fibroblasts synthesize and secrete Type
collagen fibrils and induce deposition of calcium
salt crystals in the collagen fibrils. b. Fibroblasts
produce matrix vesicles in their surroundings. These
matrix vesicles become calcified and turn into floccu-
lent calcospherules which coalesce and fuse into bone
tissues. c. Fibroblasts harbor calcium granules in
their mitochondria, thus providing calcium for calci-
fication of the intercellular matrix and bone forma
tion between the cells. d. Fibroblasts can transform
directly into osteocytes; there is bone formation
around the fibroblasts, the bone tissues surround the
fibroblast in the form of bony lacuna, then the fibro-
blast in the lacuna transforms into osteocyte. e.
Fibroblasts can undergo degenerative changes leading
to decease and replacement by bone tissues. 相似文献
78.
X J Zhang K R Kunkel F Jahoor R R Wolfe 《JPEN. Journal of parenteral and enteral nutrition》1991,15(4):394-399
We have investigated the role of basal insulin concentration on leucine kinetics (determined by means of 1-[13C]leucine) and energy metabolism (determined by indirect calorimetry) in eight septic patients by reducing insulin (and glucagon) secretion by somatostatin infusion. Basal glucagon concentration was elevated (744 +/- 381 pg/mL), and insulin concentration was normal (10 +/- 4 microU/mL). Basal resting energy expenditure (REE) was 151 +/- 8% that of predicted basal energy expenditure, and leucine appearance (Ra), oxidation, and nonoxidative disposal rates were all elevated above the normal ranges. Somatostatin infusion reduced insulin concentration by 52% and glucagon concentration by 64%. This resulted in a significant increase in the rate of leucine oxidation from 0.96 +/- 0.08 to 1.18 +/- 0.14 mumol/kg/min (p less than 0.01), and nonoxidative leucine disposal decreased from 2.95 +/- 0.18 to 2.67 +/- 0.17 mumol/kg/min (p less than 0.01). Somatostatin infusion also caused significant increases in REE and fat oxidation from 1310 +/- 100 to 1505 +/- 128 kcal/m2/day (p less than 0.05) and from 1.72 +/- 0.24 to 2.41 +/- 0.41 mg/kg/min, respectively, and a slight decrease of carbohydrate oxidation from 1.51 +/- 0.49 to 1.31 +/- 0.49 mg/kg/min. These metabolic responses can be attributed to the reduction in insulin concentration, because they are in the opposite direction of changes that would occur as a consequence of a reduction in glucagon concentration. We conclude that the basal insulin plays an important role in attenuating net protein loss and energy expenditure. 相似文献
79.
80.
特异性荧光偏振免疫法监测521例肾移植后环孢素A全血浓度3275次 总被引:2,自引:0,他引:2
目的通过监测肾移植后病人环孢素A(CsA)全血浓度 ,提出CsA在三联免疫抑制用药方案中的理想治疗窗。方法用特异性荧光偏振免疫法测定CsA全血浓度 ,对521例病人监测3275次 ,按术后时间及临床表现分组比较。结果肾移植后<1 ,、1~3、3~6、6~12个月、1~2和>2年的CsA全血谷浓度的理想治疗窗应分别为250~450、200~400、150~300、100~250、100~200和100~180μg/L。结论CsA全血浓度在上述范围内 ,中毒反应和排异反应明显减少 相似文献