Variabilidad en el consumo de recursos en pacientes con espondiloartritis en España. Datos descriptivos preliminares del estudio emAR II

ObjectiveOur objective was to describe the variability in the management of spondyloarthritis (SA) in Spain in terms of healthcare resources and their use.MethodsA review of 1168 medical files of patients seen in randomly selected Spanish hospital rheumatology departments. We analyzed demographic variables and variables related to the consumption of health resources.ResultsThe total number of visits to rheumatology were 5,908 with a rate of 254 visits/100 patient-years. The total number of visits to rheumatology specialty nurses was 775, with a rate of 39 visits/100 patient-years, and there were 446 hospitalizations, representing a rate of 22 per 100 patient-years. The number of admissions due to SA was 89, with a rate of 18 admissions/100 patient-years. Total visits to other specialists was 4,307 with a rate of 200/100 patient-years. The total number of orthopedic surgeries was 41, which leads to a rate of 1.8 surgeries/100 patient-years.ConclusionsThe data regarding visits to the rheumatologist and prosthetic surgery of patients with in Spain is similar to most studies published in our environment, however, other aspects concerning the use of health resources are different compared to other countries. This data may help to understand and improve organizational aspects of management of SA in Spanish hospitals.     

还原型谷胱甘肽对慢性阻塞性肺疾病急性加重期患者氧化应激的影响

目的 研究还原型谷胱甘肽对慢性阻塞性肺疾病(COPD)急性加重期患者氧化与抗氧化能力的影响.方法 检测20例健康成年人全血丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)含量,并与72例COPD急性加重期患者治疗前的上述指标进行对应比较,发现COPD急性加重期的全血GSH-PX的活性比健康组低,而MDA的含量比健康...     

血清胱抑素C对老年人脑萎缩的预测价值

目的研究血清胱抑素C(CysC)与老年人脑萎缩疾病的关系,探讨血清CysC对疾病的预测价值。方法收集114例脑萎缩组与127例非脑萎缩组患者的临床、实验室及影像学资料,比较两组间各因素差异,Logistic回归分析独立危险因素。通过头部CT检查对脑萎缩组进行评估,分析血清Cys与脑萎缩严重程度的相关性。绘制血清CysC对老年人脑萎缩患病的ROC预测曲线。结果血清CysC是老年人脑萎缩的独立危险因素(P0.05,OR值0.030,95%CI 0.007~0.124)。ROC曲线下面积为0.699(95%CI 0.634~0.765),最佳诊断界值为1.09 mmol/L。血清CysC与老年人脑萎缩严重程度呈正相关(r1=0.229,P10.05;r2=0.223,P20.05)。结论血清CysC与老年人脑萎缩发生和发展存在相关性,并存在一定预测价值。     

Influence of Some Psychosocial Factors on Mobbing and its Consequences Among Employees Working with People with Intellectual Disabilities

Background The problem of mobbing has attracted a great deal of attention over the past few years. This concern has increased the study of the phenomena, which has resulted in many scientific publications. Mobbing has been characterized as an emerging risk at work. The aim of this study was to analyse the influence of some psychosocial factors at work – role clarity, interpersonal conflicts and social support – on mobbing and its consequences – that is, inclination towards absenteeism and psychosomatic disorders. Materials and methods The sample included 422 employees working with people with intellectual disabilities. Structural equation modelling (SEM) was used to test the hypotheses. Results The Hypothesized model showed an adequate fit to data, and all hypothesized relationships were significant. Conclusions The results of this study provide support for the mediator role of mobbing in the relationship between high role ambiguity, low social support and high interpersonal conflicts and psychosomatic disorders and inclination towards absenteeism.     

洛阳市手足口病危重型78例

目的分析手足口病(HFMD)危重型的临床特点,为诊断提供线索。方法对本院2010年收治的HFMD危重型78例患儿的发病特点、临床表现、辅助检查结果进行分析。结果病例分布在5-11月,呈2个高峰。59例居住在农村,26/31例为EV71感染,70例为3岁以下,男女比例为1.791.0,61例于病程3 d内出现危重表现。三凹征阳性59例,休克42例,肺部啰音36例,血性泡沫痰23例,昏迷16例,频繁抽搐11例,脑疝4例。尿糖、血糖、血WBC和PLT、心肌酶、ALT、二氧化碳分压、脑压、脑脊液白细胞数和蛋白升高,血氧分压、pH值、二氧化碳结合力降低,胸片、ECG、EEG、MRI等部分患儿出现异常。结论 HFMD危重型以呼吸系统危重表现多见,应动态监测血气、胸片等。     

牙龈卟啉单胞菌对人脐静脉血管内皮细胞cGMP生成的影响

目的:体外研究牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)对人脐静脉血管内皮细胞(human umbilical vein endothelial cell,HUVEC)cGMP水平的影响。方法:用Pg ATCC 33277分别以感染复数(multiplicity of infection,MOI)1∶10、1∶50、1∶250干预HUVEC,并以未受Pg ATCC 33277干预的HUVEC作为阴性对照,分别培养4、12、36 h,在倒置显微镜下观察各组细胞形态;125I cGMP放射免疫试剂盒检测各组HUVECcGMP的水平。结果:与对照组相比,Pg ATCC 33277分别以MOI 1∶10、1∶50、1∶250干预HUVEC 4、12、36 h后,实验各组HUVEC的细胞形态未见明显改变,仍呈典型的"铺路石"状单层贴壁生长;Pg ATCC 33277 MOI1∶250时可呈时间依赖性地降低HUVEC cGMP水平,而同一时间点内,各浓度组的cGMP水平并无明显差异。结论:短时间内,Pg ATCC 33277对HUVEC的细胞形态无明显影响,但可降低HUVEC cGMP的生成,HUVECNO生物利用度下降。     

樱花全自动密闭式组织脱水机应用体会

目的提高组织标本处理质量,更好发挥脱水机的作用。方法在使用日本樱花(SAKURA)全自动密闭式组织脱水机过程中,对设置程序、试剂更换和管道清洗,对仪器使用、维护、保养和常见故障排除等方面进行探讨。结果处理组织标本效率提高,处理效果得到改善,制作的切片达到优质切片质量标准。结论对SAKURA全自动密闭式组织脱水机的使用,不能过于机械地照搬固有操作模式,只有在工作中不断摸索才能更好应用,使3种不同型号全自动密闭式组织脱水机衔接起来,达到组织标本处理标准化和规范化。