黄甘草异黄酮成分的研究

从黄甘草(Glycyrrhiza eurycarpa P.C.Li)根及根茎中分得五个异黄酮化合物,根据理化性质及光谱(UV,MS,¹HNMR,¹³CNMR,NOE,HMBC)数据分析,化合物I的结构推定为7,2′,4′-三羟基-3′-异戊烯基异黄酮,为一新化合物,命名为黄甘草异黄酮A(eurycarpinA)。化合物I的结构推定为7,2′-二羟基-(2″,3″∶4′,3′)-6″,6″-二甲基吡喃异黄酮,为一新的天然产物,命名为黄甘草异黄酮B(eurycarpinB)。其余化合物分别鉴定为 licoisoflavone A(III),毛蕊异黄酮(calycosin,IV)和芒柄花素(formononetin,V)。化合物II～V均为首次从本植物中得到。     

有关中药黄芪药理研究的若干问题的探讨

1原文研究要点 作者为了研究中药黄芪(AMB)提取物对体外培养的肝癌细胞的抑制活性,将ANMB经粉碎、浸提、超速离心、减压浓缩、冷冻干燥得到AMB提取物.然后,以AMB提取物按不同时间处理人肝癌SMMC-7721细胞,再以MTT法检测其对人肝癌SMMC-7721细胞线粒体代谢活性的影响,以细胞记数法观察了其对细胞增殖的影响.     

The relationship between birth weight and feeding maturation in preterm infants

Aim: To report changes in ingestive behaviour from 35 to 40 weeks post-conceptual age and examine the association between birth weight and feeding maturation in preterm infants.
Methods: One hundred and four preterm infants born 24 to 34 weeks gestational age were studied. Feeding maturation was assessed as the change from 35 to 40 weeks post-conceptual age in the number of sucks over 5 min, sucking bursts, sucks per burst, time between bursts and maximum pressure during a suck (Pmax). The association between birth weight and each sucking behaviour was examined after adjusting for potential confounders.
Results: Significant changes in feeding maturation occurred between 35 and 40 weeks. Birth weight was positively associated with change in Pmax and change in number of sucks per burst for extremely premature infants born 24 to <29 weeks gestational age but not for very premature infants born ≥29 to 34 weeks. The association between birth weight and change in Pmax for extremely premature infants remained significant after adjustment (adjusted beta = 0.128 mmHg increase in change in maximum sucking pressure per every 1 g of birth weight, 95% CI = 0.017, 0.239, p = 0.03).
Conclusion: Birth weight is positively associated with maturation in maximum sucking pressure among infants born extremely premature.     

三七中人参三醇甙抗心律失常作用的研究

三七三醇甙(PTS)为三七的组分之一,能明显对抗乌头碱、BaCl_2和肾上腺素诱发的实验性心律失常。PTS减慢大鼠心率,延长P-R和Q-Tc间期;减慢离体豚鼠右房自发频率;使异丙肾上腺素加速右房自发频率的量效-曲线右移并抑制最大效应。PTS与胺碘达隆作用相似,使离体豚鼠乳头状肌细胞电位APD和ERP显著延长,2相复极化斜率降低。PTS对上述动作电位的影响呈剂量依赖性关系。     

粗毛淫羊藿甙的分离和结构

粗毛淫羊藿Epimedium acuminatum Franch为小檗科植物,又名尖叶淫羊藿,分布于四川、云南、贵州和湖北,在当地作淫羊藿药用。对粗毛淫羊藿的化学成分研究尚未见报道。本文报道从四川产粗毛淫羊藿的地上部分分离到五个化合物并进行了结构研究。     

滇黄芩中滇黄芩新素的结构研究

前已报道自四川产滇黄芩Scutellaria,amoena C.H.Wright中分离出五种黄酮成分和从云南产的中得到另八个黄酮类化合物。本文继续报道从云南产滇黄芩中得到的六个化合物和从四川产本种植物中得到一个黄酮化合物的结构鉴定。