全文获取类型
收费全文 | 737篇 |
免费 | 90篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 27篇 |
妇产科学 | 23篇 |
基础医学 | 110篇 |
口腔科学 | 20篇 |
临床医学 | 100篇 |
内科学 | 185篇 |
皮肤病学 | 5篇 |
神经病学 | 36篇 |
特种医学 | 109篇 |
外科学 | 76篇 |
综合类 | 20篇 |
预防医学 | 46篇 |
眼科学 | 2篇 |
药学 | 61篇 |
中国医学 | 9篇 |
肿瘤学 | 36篇 |
出版年
2021年 | 9篇 |
2020年 | 11篇 |
2019年 | 9篇 |
2018年 | 8篇 |
2017年 | 11篇 |
2016年 | 12篇 |
2015年 | 16篇 |
2014年 | 20篇 |
2013年 | 31篇 |
2012年 | 22篇 |
2011年 | 18篇 |
2010年 | 33篇 |
2009年 | 25篇 |
2008年 | 19篇 |
2007年 | 42篇 |
2006年 | 20篇 |
2005年 | 20篇 |
2004年 | 14篇 |
2003年 | 22篇 |
2002年 | 20篇 |
2001年 | 15篇 |
2000年 | 14篇 |
1999年 | 24篇 |
1998年 | 31篇 |
1997年 | 22篇 |
1996年 | 19篇 |
1995年 | 13篇 |
1994年 | 19篇 |
1993年 | 19篇 |
1992年 | 10篇 |
1991年 | 15篇 |
1990年 | 8篇 |
1989年 | 16篇 |
1988年 | 21篇 |
1987年 | 14篇 |
1986年 | 19篇 |
1985年 | 16篇 |
1984年 | 9篇 |
1983年 | 15篇 |
1982年 | 7篇 |
1980年 | 9篇 |
1979年 | 8篇 |
1976年 | 8篇 |
1969年 | 7篇 |
1967年 | 5篇 |
1944年 | 5篇 |
1841年 | 7篇 |
1840年 | 13篇 |
1838年 | 8篇 |
1830年 | 5篇 |
排序方式: 共有867条查询结果,搜索用时 15 毫秒
861.
862.
东北红豆杉枝叶化学成分的研究 总被引:20,自引:0,他引:20
东北红豆杉(Taxus cuspidata SibeetZucc)枝叶乙醇提取物的二氯甲烷溶部分显示有较强的抗肿瘤活性,从这部分中已分离出十二个紫杉烷类二萜化合物,经理化常数测定和光谱解析证明其中十个为已知化合物taxinine(I),taxinineA(II),taxinineB(III),taxacin(V),taxagifine(VI),taxol(VII),cephalomannine(VIII),taxinineM(IX),10-deacetyl baccatinIII(X)和taxayuntin(XI),另二个化合物为新成分,分别命名为10-deacetyl taxinineB(IV)和taxacustin(XII),其中化合物VII,VIII,IX,X和XI均为首次从该植物枝叶中分离得到。 相似文献
863.
Xavier Bonfill María Jos Martinez-Zapata Leslie Barrionuevo-Rosas Robin WM Vernooij María Jos Snchez María Morales-Surez-Varela Javier De la Cruz Jos Ignacio Emparanza Montserrat Ferrer Jos Ignacio Pijoan Joan Palou Albert Frances Eva Madrid Claudia Coscia Javier Zamora 《Medicine》2022,101(42)
The therapeutic approach of bladder cancer strongly determines its prognosis. We describe the treatments and outcomes for a Spanish cohort of patients with bladder cancer for the first 12 months after diagnosis and identify the factors that influenced the decision to undergo the treatment received. We conducted a multicenter, prospective, cohort study including primary bladder cancer patients during the first 12 months after diagnosis. The clinical outcomes were performance status (ECOG), adverse events and any cause of mortality. We stratified the analysis by factors that might influence the treatments received. We conducted univariate and multivariable logistic regression models to assess which patient and tumor characteristics were associated with receiving adjuvant treatment in the subgroup of noninvasive bladder cancer patients. In total, 314 patients were included (85% men; 53.8% >70 years) in 7 tertiary Spanish hospitals; 82.2% had a noninvasive urothelial bladder cancer (NMIBC). Patients received mostly surgery plus adjuvant therapy (67.7%). BCG (32.8% patients) was the most frequently administered adjuvant therapy, followed by intravesical chemotherapy (17.8% patients) and radiotherapy (10.8%). The variability of administered treatments among hospitals was low. Patients with NMIBC were more likely to receive adjuvant therapy if they had a higher educational level, some comorbidities and a high-grade tumor. The number of fully active patients (ECOG 0) significantly decreased during the first year of follow-up from 58% to 36 % (OR: 2.41, 95%CI 1.82–3.20); at 12-month follow-up 10.8% patients had died from any cause. In conclusion, most of the patients had a NMIBC. Surgery alone or plus adjuvant therapy were the commonest curative options of bladder cancer. BCG therapy was the adjuvant therapy most frequently administered. Higher educational level, presence of comorbidities and a high-grade tumor were associated with adjuvant therapy. Patient performance status was worsening over time. Almost 1 of 10 patients died during the first year of follow-up. 相似文献
864.
Julie A. Womack MSN PhD Terrence E. Murphy PhD Linda Leo-Summers MPH Jonathan Bates PhD Samah Jarad PhD Thomas M. Gill MD Evelyn Hsieh MD PhD Maria C. Rodriguez-Barradas MD Phyllis C. Tien MD Michael T. Yin MD Cynthia A. Brandt MPH MD Amy C. Justice MD PhD 《Journal of the American Geriatrics Society》2023,71(6):1891-1901
865.
Ben M Eyck Maurice PHM Jansen Bo Jan Noordman Peggy N Atmodimedjo Berend J van der Wilk John WM Martens Jean A Helmijr Corine M Beaufort Bianca Mostert Michail Doukas Bas PL Wijnhoven Sjoerd M Lagarde J Jan B van Lanschot Winand NM Dinjens 《The Journal of pathology》2023,259(1):35-45
Active surveillance instead of standard surgery after neoadjuvant chemoradiotherapy (nCRT) has been proposed for patients with oesophageal cancer. Circulating tumour DNA (ctDNA) may be used to facilitate selection of patients for surgery. We show that detection of ctDNA after nCRT seems highly suggestive of major residual disease. Tumour biopsies and blood samples were taken before, and 6 and 12 weeks after, nCRT. Biopsies were analysed with regular targeted next-generation sequencing (NGS). Circulating cell-free DNA (cfDNA) was analysed using targeted NGS with unique molecular identifiers and digital polymerase chain reaction. cfDNA mutations matching pre-treatment biopsy mutations confirmed the presence of ctDNA. In total, 31 patients were included, of whom 24 had a biopsy mutation that was potentially detectable in cfDNA (77%). Pre-treatment ctDNA was detected in nine of 24 patients (38%), four of whom had incurable disease progression before surgery. Pre-treatment ctDNA detection had a sensitivity of 47% (95% CI 24–71) (8/17), specificity of 85% (95% CI 42–99) (6/7), positive predictive value (PPV) of 89% (95% CI 51–99) (8/9), and negative predictive value (NPV) of 40% (95% CI 17–67) (6/15) for detecting major residual disease (>10% residue in the resection specimen or progression before surgery). After nCRT, ctDNA was detected in three patients, two of whom had disease progression. Post-nCRT ctDNA detection had a sensitivity of 21% (95% CI 6–51) (3/14), specificity of 100% (95% CI 56–100) (7/7), PPV of 100% (95% CI 31–100) (3/3), and NPV of 39% (95% CI 18–64) (7/18) for detecting major residual disease. The addition of ctDNA to the current set of diagnostics did not lead to more patients being clinically identified with residual disease. These results indicate that pre-treatment and post-nCRT ctDNA detection may be useful in identifying patients at high risk of disease progression. The addition of ctDNA analysis to the current set of diagnostic modalities may not improve detection of residual disease after nCRT. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 相似文献
866.
Joseph L. Goulet PhD Allison R. Warren PhD T. Elizabeth Workman PhD Melissa Skanderson MSW Melissa M. Farmer PhD Kirsha S. Gordon PhD Erica A. Abel PhD Kathleen M. Akgün MD MS Bevanne Bean-Mayberry MD MHS Qing Zeng-Treitler PhD Taona P. Haderlein PhD MA Sally G. Haskell MD MS Lori A. Bastian MD MPH Julie A. Womack PhD CNM FNP-BC Lori A. Post PhD Ula Hwang MD MPH Cynthia A. Brandt MD MPH 《Academic emergency medicine》2023,30(4):420-423
867.