全文获取类型
收费全文 | 5507篇 |
免费 | 215篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 225篇 |
儿科学 | 202篇 |
妇产科学 | 145篇 |
基础医学 | 634篇 |
口腔科学 | 34篇 |
临床医学 | 469篇 |
内科学 | 1586篇 |
皮肤病学 | 77篇 |
神经病学 | 387篇 |
特种医学 | 96篇 |
外科学 | 592篇 |
综合类 | 38篇 |
一般理论 | 2篇 |
预防医学 | 390篇 |
眼科学 | 129篇 |
药学 | 489篇 |
中国医学 | 2篇 |
肿瘤学 | 252篇 |
出版年
2023年 | 29篇 |
2022年 | 165篇 |
2021年 | 286篇 |
2020年 | 79篇 |
2019年 | 107篇 |
2018年 | 154篇 |
2017年 | 115篇 |
2016年 | 103篇 |
2015年 | 110篇 |
2014年 | 166篇 |
2013年 | 253篇 |
2012年 | 369篇 |
2011年 | 413篇 |
2010年 | 208篇 |
2009年 | 148篇 |
2008年 | 293篇 |
2007年 | 343篇 |
2006年 | 345篇 |
2005年 | 357篇 |
2004年 | 334篇 |
2003年 | 289篇 |
2002年 | 261篇 |
2001年 | 56篇 |
2000年 | 66篇 |
1999年 | 46篇 |
1998年 | 29篇 |
1997年 | 20篇 |
1996年 | 14篇 |
1995年 | 16篇 |
1994年 | 19篇 |
1993年 | 17篇 |
1992年 | 32篇 |
1991年 | 40篇 |
1990年 | 36篇 |
1989年 | 41篇 |
1988年 | 33篇 |
1987年 | 25篇 |
1986年 | 29篇 |
1985年 | 31篇 |
1984年 | 27篇 |
1983年 | 25篇 |
1982年 | 23篇 |
1980年 | 20篇 |
1979年 | 27篇 |
1978年 | 14篇 |
1977年 | 16篇 |
1976年 | 12篇 |
1975年 | 13篇 |
1973年 | 12篇 |
1972年 | 22篇 |
排序方式: 共有5749条查询结果,搜索用时 0 毫秒
41.
Karolina Orywal Katarzyna Socha Patryk Nowakowski Wojciech Zo Barbara Mroczko Maciej Perkowski 《Nutrients》2022,14(13)
Dried mushrooms might be a source of mineral components, which are indispensable for human health. The aim of this study was to determine the contents of calcium (Ca), magnesium (Mg), iron (Fe), zinc (Zn), copper (Cu), manganese (Mn), and selenium (Se) in dried wild-grown mushrooms (Boletus edulis and Xerocomus badius) available for sale, and to evaluate these mushrooms’ contribution to the daily reference intake of the studied bioelements. The concentrations of mineral components in the mushroom samples were determined by the flame method (Ca, Mg, Fe, Zn, Cu, Mn) and the electrothermal (Se) atomic absorption spectrometry method. The mean Ca, Mg, Fe, Zn, Cu, Mn (in mg/kg), and Se concentrations (in µg/kg) in B. edulis were 82.1, 964.1, 233.4, 97.9, 25.3, 22.1, and 6501.6, respectively, whereas in X. badius: 67.5, 1060.2, 87.8, 197.2, 33.9, 19.8, and 282.4, respectively. We have shown that dried B. edulis can be considered a source of Se. In the case of the other microelements, the tested mushrooms may serve only as additional supplements. Therefore, the studied species of mushrooms cannot be regarded as potential nutritional sources of the macroelements in question. Consumers should be properly informed about this, which should be guaranteed by appropriate legal regulations. 相似文献
42.
Horsmans Y Hu K Ruffin M Wang Y Song D Bouillaud E Wang Y Mazur D Botha FP Heuman DM 《Journal of clinical pharmacology》2012,52(4):552-558
Pasireotide is a novel, multireceptor-targeted somatostatin analogue with high affinity for sst(1,2,3) and sst(5) under clinical evaluation in tumors of neuroendocrine origin, including Cushing's disease, acromegaly, and neuroendocrine tumors. In this phase I, open-label, multicenter study, the pharmacokinetics and safety of a single subcutaneous (SC) injection of pasireotide 600 μg were evaluated in adults with normal hepatic function (n = 15) and mild (n = 6), moderate (n = 7), or severe hepatic impairment (n = 6). Following a single dose of pasireotide SC 600 μg, there were no significant differences in the plasma exposure of pasireotide between participants with normal hepatic function or mild hepatic impairment. Subjects with moderate and severe hepatic impairment showed an increase in AUC(∞) by 56% and 42%, respectively; this increase was 60% and 79% respectively, after adjusting for differences in age, BMI, and baseline serum albumin level between treatment groups. The incidence and severity of adverse events were similar across cohorts, with no clinically relevant differences in type or frequency of adverse events between cohorts. In conclusion, a single dose of pasireotide SC 600 μg was well tolerated in subjects with hepatic impairment. Drug exposure in subjects with mild hepatic impairment was similar to that seen in healthy volunteers, whereas subjects with moderate and severe hepatic impairment experienced higher exposure to pasireotide. Adjustment of the pasireotide dose may be required for patients with moderate and severe hepatic impairment. 相似文献
43.
Kuś E Kazimierak W Swierczewski A Kowalska-Koprek U Karowicz-Bilińska A 《Ginekologia polska》2008,79(3):212-217
Le?niowski-Crohn disease is an inflammatory process, involving all layers of the intestine, mesentery and regional lymph nodes. During the development of the disease, a thickening of the intestine wall, stricture of its lumen and adhesions have been observed. The aim of the study was to present the case of a 27-year-old pregnant woman with Crohn's disease, a very rare complication of gestation. 相似文献
44.
Wróblewska-Adamek I Wyszyńska M Kabała-Dzik A Mleczko W Picheta A 《Ginekologia polska》2007,78(4):303-306
OBJECTIVES: The aim of the study was to analyze the incidence of malignant cervical carcinomas found in the material from Histopathological Laboratory in Zawiercie District Hospital. MATERIAL AND METHODS: The examined materials included histopathological results concerning segments and scrapings from gynecological procedures and the results of the segments, collected during gynecological operations performed in the years 2000-2005, in which malignant neoplasms of uterine cervix had been diagnosed. The data concerning the neoplasms were analysed, taking into account the following parameters: the number of neoplasms found in relation to the total number of diagnostic procedures performed, patients' age, histological type of the neoplasm and the degree of clinical progression based on FIGO classification. RESULTS: In the examined material, there were 50 cases of cervical carcinomas, with the highest incidence in patients aged between 50-59. The most common morphological type was squamous carcinoma and the majority of cervical carcinomas was characterized by the I degrees of disease clinical progression--38 cases, also 4 preinvasive carcinomas were found and 8 cancers of the II degrees of progression, according to FIGO classification. CONCLUSION: A considerable decrease of cervical carcinomas incidence, observed in the study period and the number of neoplasms found in an early progression stage are the effect of conducted screening examinations, due to which precancerous conditions are diagnosed and treated. 相似文献
45.
Surgical treatment of stress urinary incontinence using the tension-free vaginal tape-obturator system (TVT-O) technique 总被引:1,自引:0,他引:1
Jakimiuk AJ Maciejewski T Fritz A Borucki W Namirski M Szafranko K 《European journal of obstetrics, gynecology, and reproductive biology》2007,135(1):127-131
OBJECTIVE: The purpose of the research was to provide a review of the efficacy of the TVT-O technique for the surgical treatment of stress urinary incontinence (SUI) and to assess surgical and postsurgical complications related to this technique. STUDY DESIGN: An initial assessment was carried out on 44 women who underwent TVT-O surgery between 16 September 2004 and 1 February 2005. The follow-ups after 3 and 12 months were attended by 37 and 35 patients, respectively. All 44 patients were included for the statistical estimation of intra- and postoperative complications, whereas improvement in the quality of life was assessed only in those patients who came for a follow-up visit. To assess the efficacy of the treatment, the participants were surveyed using the King questionnaire on the day preceding surgery and during a follow-up visit 3 and 12 months after surgery. The participants whose scores from the two questionnaires changed > or =90% were deemed to be cured. A considerable improvement in quality of life was recorded when the score was 89-75%. With scores of 74-50%, there was a reduction in SI symptoms. However, when the score was 50-0%, no improvement in quality of life was reported, and in participants with scores <0% the quality of life deteriorated. Statistical analysis was carried out using the Statistical Package for Social Sciences (SPSS) V. 10.0, with the Spearman correlation and Chi-squared tests. The results were considered statistically significant when P<0.05. RESULTS: After 12 months, total cure was achieved in 15 participants (42.8%), significant improvement was noted in 6 (17.1%), SUI symptoms abated in 4 (11.4%), no improvement was noted in 7 (20%), and quality of life deteriorated in 3 (8.7%). CONCLUSION: TVT-O surgery is an efficient and reasonably safe method of SUI treatment in women. The ease of use, short duration of surgery and hospitalisation, minor postsurgical discomfort and a small proportion of complications make this method acceptable to patients. With regard to the results of treatment, additional patients should be analysed for a longer period of time. 相似文献
46.
Fredrik Blomgren Alexander Rodin Wojciech Chrobak Dawid Wojciech Pacut Jan Swenson Inna Ermilova 《RSC advances》2022,12(21):13352
In this work, possible effective mechanisms of cromolyn, atorvastatin and lovastatin on the cytotoxicity of Aβ(31–35) and Aβ(25–35) peptides were investigated by classical molecular dynamics and well-tempered metadynamics simulations. The results demonstrate that all the drugs affect the behavior of the peptides, such as their ability to aggregate, and alter their secondary structures and their affinity to a particular drug. Our findings from the computed properties suggest that the best drug candidate is lovastatin. This medicine inhibits peptide aggregation, adsorbs the peptides on the surface of the drug clusters, changes the secondary structure and binds to MET35, which has been seen as the reason for the toxicity of the studied peptide sequences. Moreover, lovastatin is the drug which previously has demonstrated the strongest ability to penetrate the blood–brain barrier and makes lovastatin the most promising medicine among the three investigated drugs. Atorvastatin is also seen as a potential candidate if its penetration through the blood–brain barrier could be improved. Otherwise, its properties are even better than the ones demonstrated by lovastatin. Cromolyn appears to be less interesting as an anti-aggregant from the computational data, in comparison to the two statins.In this work, possible effective mechanisms of cromolyn, atorvastatin and lovastatin on the cytotoxicity of Aβ(31–35) and Aβ(25–35) peptides were investigated by classical molecular dynamics and well-tempered metadynamics simulations. 相似文献
47.
Wojciech Kolanowski Franciszek Swiderski Ewa Lis Stanislaw Berger 《International journal of food sciences and nutrition》2013,64(6):469-476
Polyunsaturated fatty acids of the omega-3 series, especially very long chain – eicosapenta- and docosahexaenoic acid (EPA, DHA) – exert a strongly desirable influence on health. However, their intake with the western-style diet is usually too low which favours development of many diseases (CVD, cancers, allergies, etc.). Nowadays elevation of EPA and DHA intake is commonly recommended, but almost the only dietary source of them is seafoods, especially fish. A new way to increase the intake of long-chain omega-3 without radical changes of eating patterns is enrichment of regularly consumed foods with unhydrogenated fish oil. The aim of this study was to establish sensory and nutritionally acceptable enrichment level of low-calorie spreadable fats (soft margarine and mix of butter and vegetable oil) with EPA and DHA by addition of fish oil preparations (ROPUFA – 30% EPA, DHA and MARITEX – 10%), and evaluation of the stability of enriched spreads during storage (sensory and chemical). It was shown that tested spreadable fats might be enriched up to 1% EPA, DHA (i.e. 3% ROPUFA, 8% MARITEX), and that this had no significant influence on sensory acceptability. Both used fish oils which exerted similar influence on the quality of fats. An enriched mix of butter and vegetable oil and margarine may be stored up to 3 and 6 weeks respectively without significant decrease of quality. Peroxide value and acid numbers were not much affected by enrichment and storage. Daily portion (25–30 g/day) of spreadable fats enriched on the level established in the study may provide 0.2–0.3 g EPA, DHA, significantly increasing the amount of long-chain omega-3 in the diet above those eaten normally. 相似文献
48.
Agnieszka Mazur Anna Szylling Teresa Bielecka Marek Kulus 《The Journal of asthma》2013,50(10):1147-1155
Objective: The prevalence of allergic diseases has reached epidemic proportions in the Western world. Although farm-living has been associated with a lower prevalence of asthma and atopy, a marked increase in atopy among rural populations after accession to the European Union has been recently reported in Poland. Here, we aimed to investigate the effect of living environment on the prevalence of atopy and allergic diseases in Polish children. Methods: 400 schoolchildren aged 10–14 years from the capital city (223) and from traditional rural part of the country (177) were recruited from June to November 2011. Data on allergic diseases and symptoms were collected by means of questionnaire and physical examination. Atopy was assessed based on skin prick tests (SPTs) reactivity to inhalant allergens in 350 children. Results: A high discrepancy between the prevalence of allergic symptoms (46.7%) and doctor-diagnosed allergic diseases (25%) was demonstrated (p < 0.0001). Urban children had a higher overall prevalence of allergic diseases and atopy than children living in rural areas, 29.3% versus 17.1% (p = 0.007) and 33.5% versus 20% (p = 0.0045), respectively. However, no significant differences in the rates of particular allergic diseases were noted (p > 0.05). There was higher SPT positivity to trees, grass, corn, weeds, animal dander, and molds in urban children (p < 0.05). Conclusions: Our data support the protective effect of farm-living on the prevalence of atopy and overall allergic diseases, albeit not on particular allergic diseases, in children in Poland. The underlying mechanisms are not identified, but current socioeconomic changes may be responsible. 相似文献
49.
50.