全文获取类型
收费全文 | 2141篇 |
免费 | 237篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 92篇 |
妇产科学 | 30篇 |
基础医学 | 189篇 |
口腔科学 | 50篇 |
临床医学 | 313篇 |
内科学 | 409篇 |
皮肤病学 | 108篇 |
神经病学 | 142篇 |
特种医学 | 196篇 |
外科学 | 379篇 |
综合类 | 101篇 |
现状与发展 | 30篇 |
一般理论 | 1篇 |
预防医学 | 121篇 |
眼科学 | 21篇 |
药学 | 62篇 |
中国医学 | 5篇 |
肿瘤学 | 125篇 |
出版年
2024年 | 18篇 |
2023年 | 180篇 |
2022年 | 15篇 |
2021年 | 38篇 |
2020年 | 63篇 |
2019年 | 38篇 |
2018年 | 68篇 |
2017年 | 65篇 |
2016年 | 52篇 |
2015年 | 62篇 |
2014年 | 96篇 |
2013年 | 90篇 |
2012年 | 58篇 |
2011年 | 66篇 |
2010年 | 90篇 |
2009年 | 109篇 |
2008年 | 65篇 |
2007年 | 87篇 |
2006年 | 50篇 |
2005年 | 61篇 |
2004年 | 51篇 |
2003年 | 39篇 |
2002年 | 53篇 |
2001年 | 38篇 |
2000年 | 39篇 |
1999年 | 43篇 |
1998年 | 44篇 |
1997年 | 52篇 |
1996年 | 47篇 |
1995年 | 42篇 |
1994年 | 38篇 |
1993年 | 42篇 |
1992年 | 21篇 |
1991年 | 22篇 |
1990年 | 37篇 |
1989年 | 49篇 |
1988年 | 40篇 |
1987年 | 31篇 |
1986年 | 12篇 |
1985年 | 29篇 |
1984年 | 18篇 |
1983年 | 13篇 |
1982年 | 12篇 |
1981年 | 16篇 |
1980年 | 19篇 |
1978年 | 20篇 |
1977年 | 9篇 |
1976年 | 20篇 |
1975年 | 14篇 |
1967年 | 8篇 |
排序方式: 共有2396条查询结果,搜索用时 15 毫秒
131.
ANTHONY G CATTO-SMITH TERENCE M NOLAN CAROLYN MM COFFEY 《Journal of gastroenterology and hepatology》1998,13(9):955-960
Treatments designed to relieve paradoxical contraction of the anal sphincters during defecation (anismus) have had limited success in children with encopresis. This has raised doubts as to the clinical relevance of this diagnosis in childhood as anorectal dysfunction. Our aim was to determine whether, in patients who had treatment-resistant encopresis, the presence of electromyographic anismus was associated with increased faecal retention. Sixty-eight children with soiling (mean age 8.7 ± 2.06 years) were assessed by clinical examination, abdominal radiography and then with anorectal manometry. Patients with electromyographic anismus (n= 32; 47%) had significantly increased radiographic rectal faecal retention and were significantly less likely to be able to defecate water-filled balloons. There were no significant differences in response to prior therapy, history of primary encopresis, behavioural adjustment or in sociodemographic data. Our results suggest that electromyographic anismus is associated with obstructed defecation and faecal retention. 相似文献
132.
MM Harjai DC Agarwal P Dave SS Jog P Arora SM VSM 《Medical Journal Armed Forces India》2005,61(2):143-147
Background
The sudden increase in incidence and magnitude of mine blast injuries prompted us to highlight the problem and its management.Methods
The cases of mine blast injuries occurring during mining and demining in a particular geographical area were analysed. Total 27 cases of mine blast injuries occurred during mining or demining operations in a period of 13 months.Results
Various body regions were involved in the mine blast injuries but the main brunt was borne by feet and legs followed by multiple body regions due to splinters. 14 patients underwent below knee (BK) amputation while 4 patients required through knee (TK) amputations. The effect of blast was so severe that most of the cases required 2 to 5 times wound debridements. The initial aggressive debridement / open stump amputation saved the limb and life of all patients.Conclusion
A mine blast causes extensive injuries and psychological trauma. Management is needed urgently, surgery is difficult, and amputation is often inevitable. Maximum lives and limbs can be saved with aggressive debridement, repeated inspections and dressings under anaesthesia and definitive closure at optimum time.Key Words: Amputation, Antipersonnel mine, Crush syndrome, Debridements, Mine blast injury, Secondary missiles, Shrapenels 相似文献133.
Cleland JA Whitman JM Fritz JM Palmer JA 《The Journal of orthopaedic and sports physical therapy》2005,35(12):802-811
STUDY DESIGN: A case series of consecutive patients with cervical radiculopathy. BACKGROUND: A multitude of physical therapy interventions have been proposed to be effective in the management of cervical radiculopathy. However, outcome studies using consistent treatment approaches on a well-defined sample of patients are lacking. The purpose of this case series is to describe the outcomes of a consecutive series of patients presenting to physical therapy with cervical radiculopathy and managed with the use of manual physical therapy, cervical traction, and strengthening exercises. CASE DESCRIPTION: Eleven consecutive patients (mean age, 51.7 years; SD, 8.2) who presented with cervical radiculopathy on the initial examination were treated with a standardized approach, including manual physical therapy, cervical traction, and strengthening exercises of the deep neck flexors and scapulothoracic muscles. At the initial evaluation all patients completed self-report measures of pain and function, including a numeric pain rating scale (NPRS), the Neck Disability Index (NDI), and the Patient-Specific Functional Scale (PSFS). All patients again completed the outcome measures, in addition to the global rating of change (GROC), at the time of discharge from therapy and at a 6-month follow-up session OUTCOMES: Ten of the 11 patients (91%) demonstrated a clinically meaningful improvement in pain and function following a mean of 7.1 (SD, 1.5) physical therapy visits and at the 6-month follow-up. DISCUSSION: Ninety-one percent (10 of 11) of patients with cervical radiculopathy in this case series improved, as defined by the patients classifying their level of improvement as at least "quite a bit better" on the GROC. However, because a cause-and-effect relationship cannot be inferred from a case series, follow-up randomized clinical trials should be performed to further investigate the effectiveness of manual physical therapy, cervical traction, and strengthening exercises in a homogeneous group of patients with cervical radiculopathy. 相似文献
134.
135.
136.
An in vitro is described that attempts to detect patients with a potential for adverse systemic reactions to contrast material. This test involves measuring the rate of conversion of prekallikrein to kallikrein under certain standard conditions. In a preliminary retrospective study, the test could be used to identify such patients with a sensitivity of 88%, a specificity of 82%, and a predictive value of 79%. 相似文献
137.
Moses R. Johnson Thomas L. Whitman Rebecca Barloon-Noble 《Journal of behavior therapy and experimental psychiatry》1978,9(1):65-70
The effects of a set of reinforcement procedures upon the “autistic” behaviors of a four-year-old girl were evaluated. The study was carried out entirely in a home setting with the mother and father as change agents. The parents were trained to use, in a semi-structured play setting, through written and verbal instructions, a treatment program consisting of positive attention and timeout. Each parent independently applied the training procedures to the child's compliance, inappropriate vocalization and noncompliance behaviors. Both multiple baseline and reversal procedures were employed to assess treatment effects. Results indicated that the parents' use of the positive attention and timeout procedures was responsible for a substantial improvement in their daughter's compliance with instructions and a marked decrease in the two inappropriate responses. Comparisons across parents indicated no marked differences in the procedures' effects on the child's behaviors. 相似文献
138.
139.
Kolk SM Whitman MC Yun ME Shete P Donoghue MJ 《Molecular and cellular neurosciences》2005,30(4):538-551
Cells of the subplate (SP) and deep cortical plate (CP) are among the pioneer neurons of the developing cerebral cortex, an important group of early-born cells that impact cortical organization and function. Similarities between pioneer neurons in different cortical positions and heterogeneities in pioneer cells in the same cortical location, however, have made it difficult to appreciate the characteristics and functions of particular sets of these cells. Here, we provide a tool to illuminate a unique subset of SP and deep CP neurons: expression of a Tbrain-1 (Tbr1)-driven transgene. Transgene-expressing cells were consistently positive for neuronal but not glial markers, were born early in corticogenesis, representing just a subset of SP and deep CP neurons, were morphologically complex during the formation of the cortex, and were maintained into maturity. This analysis reveals a novel group of pioneer neurons and demonstrates unrecognized diversity within this cortical population. In the future, this information will help to uncover the roles of discrete pioneer populations in cortical development. 相似文献
140.
Friedman JE Zabriskie JB Plank C Ablashi D Whitman J Shahan B Edgell R Shieh M Rapalino O Zimmerman R Sheng D 《Multiple sclerosis (Houndmills, Basingstoke, England)》2005,11(3):286-295
OBJECTIVE: The human Herpesvirus type-6 (HHV-6) has been implicated in multiple sclerosis (MS). Valacyclovir is an antiviral agent with an excellent safety profile. A two-year placebo-controlled, double-blind study was conducted to (1) ascertain if high-dose, prolonged treatment with valacyclovir would be safe and (2) observe if valacyclovir would delay the progression of MS clinically or by magnetic resonance imaging (MRI). DESIGN/METHODS: Fifty-eight patients were stratified as to severity and randomly assigned to receive valacyclovir (3000 mg/day) or placebo for a period of two years. Patients were followed clinically over the two-year period by means of the Expanded Disability Status Scale (EDSS), the Ambulation Index (AI) and brain MRI scans. Patients underwent routine lab studies every three months. Patients continued on the medication for two years unless they had a sustained progression or repeated exacerbations. RESULTS: No patient discontinued the study due to side effects or toxicity. In Relative Ranking of Progression, time to first attack, attack rate, and time to withdrawal there were trends (but not statistically significant) toward drug effect over placebo in the Severe clinical category. MRI evaluation showed no significant drug effect. CONCLUSIONS: Although not statistically significant, positive trends were detected for acyclovir by clinical measures, but not by MRI. 相似文献