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131.
胃肠道间质瘤的临床病理研究 总被引:6,自引:0,他引:6
目的:探讨胃肠道间质瘤(gastrointestinal stromal tumor,GIST)的临床病理特点。方法:对55例GIST的病例进行分析,并对其进行CD117、CD34、S-100、SMA、vimenfin、desmin、NF共7种免疫组化分析。结果:肿瘤的发生部位:胃38例(69%),小肠10例(18%),其他部位7例(13%)。肿瘤直径0.4—40cm(平均6.7cm)。肿瘤最大直径≥5cm、核分裂像数≥5/50 HPF及有溃疡形成3项在良性与恶性之间差异有显著意义。免疫组化的阳性表达结果为:CD117 39例(71%)、CD34 45例(82%)、S-100 19例(35%)、SMA 12例(22%)、vimentin 32例(58%)、desmin 6例(11%)、NF2/4(50%)。13例良性GIST患者全部存活,42例恶性及潜在恶性GIST中有4例发生转移,13例死亡。结论:(1)GIST好发于中老年人,无明显性别差异。(2)其主要恶性指标为:肿瘤最大径≥5cm、核分裂像≥5/50 HPF和有溃疡形成。(3)光镜下很难将平滑肌性肿瘤及神经源性肿瘤与GIST相鉴别。 相似文献
132.
目的:观察吸入一氧化氮(NO)对心瓣膜置换术后肺动脉高压患者血流动力学的影响。方法:选择9例心瓣膜置换术后伴肺动脉高压的病人,吸入NO0.003%,观察三个时象点:吸入NO前;开始吸入NO后15分钟;停止吸入NO后15分钟。结果:吸入NO能显著降低肺动脉压和肺循环阻力指数(P<0.01),停止吸入NO15分钟后,肺动脉压和肺循环阻力指数恢复到原有水平。在整个观察过程中,心率、平均动脉压、中心静脉压、肺动脉楔压、体循环阻力指数和心脏指数均无显著变化(P>0.05)。结论:吸入NO具有选择性肺血管扩张作用,是治疗心瓣膜置换术后肺动脉高压的较理想药物。 相似文献
133.
Brain neurons and glial cells express Neu differentiation factor/heregulin: a survival factor for astrocytes. 总被引:8,自引:1,他引:7 下载免费PDF全文
R Pinkas-Kramarski R Eilam O Spiegler S Lavi N Liu D Chang D Wen M Schwartz Y Yarden 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(20):9387-9391
Neu differentiation factor (NDF, also called heregulin) was isolated from mesenchymal cells on the basis of its ability to elevate phosphorylation of ErbB proteins. Earlier in situ hybridization analysis showed that NDF was transcribed predominantly in the central nervous system during embryonic development. To gain insights into the role of NDF in brain we analyzed its distribution by immunohistochemistry and in situ hybridization. Late-gestation (day 17) rat embryos displayed high NDF immunoreactivity in both motor (e.g., putamen) and limbic (e.g., septum) regions. Lower levels of the factor were exhibited by adult brain, except for the cerebellum, where NDF expression was increased postnatally. Both neurons and glial cells were identified by immunohistochemistry as NDF-producing cells (e.g., pyramidal neurons in the cerebral cortex and glial cells in the corpus callosum). By establishment of primary cultures of rat brain cells we confirmed that NDF was expressed in neurons as well as in astrocytes. In addition, by using such primary cultures we observed that NDF treatment exerted only a limited mitogenic effect, which was accompanied by significant acceleration of astrocyte maturation. Furthermore, long-term incubation with the factor specifically protected astrocytes from apoptosis, implying that NDF functions in brain as a survival and maturation factor for astrocytes. 相似文献
134.
135.
98例颅内肿瘤经手术和病理检查证实,其中36例脑瘤伴精神障碍,最常见的精神症状是情感淡漠,情感不稳,遗忘,意识模糊,嗜睡、痴呆。为最常见的部位为额顶部和颞叶部。 相似文献
136.
PharmacokineticsofintravenouslyadministeredsodiumdichloroacetateinrabbitsGuBin(顾斌);SongLing(宋岭);JiangYongpei(蒋永培);WenAidong(文... 相似文献
137.
卒中急性期病人中医综合康复护理效果观察 总被引:2,自引:1,他引:1
[目的]探讨中医综合康复护理对卒中急性期病人神经功能缺损及日常生活能力(ADL)的影响。[方法]选择2004年9月-2006年9月在3家协作医院住院的卒中急性期238例病人为研究对象,随机分为实验组和对照组,两组药物治疗基本相同。实验组按中医综合康复护理方案进行护理.对照组采用卒中护理常规进行护理。对入选的病人在入院第1周内和4周后进行神经功能缺损及ADL的评定。[结果]4周后实验组在临床神经功能缺损、ADL等方面明显优于对照组,差异有统计学意义(P〈0.01)。[结论]中医综合康复护理可促进肢体的功能恢复,提高病人的ADL。 相似文献
138.
139.
Michael D Seidman Mumtaz J Khan Wen Xue Tang Wayne S Quirk 《Otolaryngology--head and neck surgery》2002,127(3):138-144
OBJECTIVES: Lecithin is a polyunsaturated phosphatidylcholine (PPC), which are high energy functional and structural elements of all biologic membranes. PPC play a rate-limiting role in the activation of numerous membrane-located enzymes, including superoxide dismutase and glutathione, which are important antioxidants protecting cell membranes from damage by reactive oxygen species (ROS). ROS-induced damage to mitochondrial DNA may lead to reduced mitochondrial function in the cochlea and resultant hearing loss. STUDY DESIGN AND SETTING: The effects of lecithin on aging and age-associated hearing loss were studied in rats by measuring hearing sensitivities using auditory brainstem responses (ABR). In addition, mitochondrial function as a measure of aging was assessed by determining mitochondrial membrane potentials using flow cytometry and by amplifying mitochondrial DNA deletions associated with aging. Harlan-Fischer rats aged 18 to 20 months (n = 14) were divided into 2 groups. The experimental group was supplemented orally for 6 months with lecithin, a purified extract of soybean phospholipid (Nutritional Therapeutics, Allendale, NJ). RESULTS: The data obtained were compared with the control group. ABRs were recorded at 2-month intervals and showed significant preservation of hearing sensitivities in the treated subjects. Flow cytometry revealed significantly higher mitochondrial membrane potentials in the treated subjects, suggesting preserved mitochondrial function. Finally, the common aging mitochondrial DNA deletion (mtDNA(4834)) were amplified from brain and cochlear tissue including stria vascularis and auditory nerve. This specific deletion was found significantly less frequent in all tissues in the treated group compared with the controls. CONCLUSION: These experiments support our hypothesis and provide evidence that lecithin may preserve cochlear mitochondrial function and protect hearing loss associated with aging. 相似文献
140.
替米沙坦治疗原发性高血压的疗效和安全性 总被引:1,自引:0,他引:1
目的 :观察替米沙坦治疗原发性高血压的疗效和安全性。方法 :进行随机、双盲、双模拟、平行分组对照试验。符合条件的轻中度高血压患者随机分为 2组 :替米沙坦组和氯沙坦组。每天一次口服替米沙坦 40mg或氯沙坦 5 0mg ,每 2周随访 1次。 4周后 ,如患者舒张压 (DBP)≥ 90mmHg则增加剂量 ,每天一次口服替米沙坦 80mg或氯沙坦 10 0mg。治疗前后分别查心电图 ,血、尿常规 ,血生化检查和常规查体。 结果 :(1)治疗 8周末 ,替米沙坦组和氯沙坦组患者的DBP均显著降低 ,2组下降幅度相似 (11.9mmHgvs 10 .4mmHg) ;(2 )治疗8周末 ,替米沙坦组收缩压 (SBP)下降幅度稍大于氯沙坦组 (9.5mmHgvs 6.2mmHg) ;(3 )替米沙坦降压有效率为 83 .3 % ,稍高于氯沙坦组 69.2 % ,无统计学差异 ;(4 ) 2组的不良事件发生率相似 (替米沙坦组 3 3 .3 % ,氯沙坦组 3 4.6% )。最常见的不良事件是头晕、头痛 ,多为轻度 ,可迅速缓解。结论 :替米沙坦 40mg~ 80mg ,每天一次口服治疗轻中度高血压安全有效 相似文献