全文获取类型
收费全文 | 79994篇 |
免费 | 8188篇 |
国内免费 | 5653篇 |
专业分类
耳鼻咽喉 | 641篇 |
儿科学 | 966篇 |
妇产科学 | 1136篇 |
基础医学 | 8950篇 |
口腔科学 | 1398篇 |
临床医学 | 10065篇 |
内科学 | 11793篇 |
皮肤病学 | 801篇 |
神经病学 | 4036篇 |
特种医学 | 2852篇 |
外国民族医学 | 37篇 |
外科学 | 8301篇 |
综合类 | 14334篇 |
现状与发展 | 29篇 |
一般理论 | 8篇 |
预防医学 | 5934篇 |
眼科学 | 1917篇 |
药学 | 8695篇 |
64篇 | |
中国医学 | 4632篇 |
肿瘤学 | 7246篇 |
出版年
2024年 | 216篇 |
2023年 | 1018篇 |
2022年 | 2473篇 |
2021年 | 3625篇 |
2020年 | 2870篇 |
2019年 | 2525篇 |
2018年 | 2659篇 |
2017年 | 2606篇 |
2016年 | 2371篇 |
2015年 | 3614篇 |
2014年 | 4411篇 |
2013年 | 4242篇 |
2012年 | 6140篇 |
2011年 | 6409篇 |
2010年 | 4351篇 |
2009年 | 3601篇 |
2008年 | 4462篇 |
2007年 | 4512篇 |
2006年 | 4145篇 |
2005年 | 4055篇 |
2004年 | 3176篇 |
2003年 | 3363篇 |
2002年 | 2817篇 |
2001年 | 2256篇 |
2000年 | 1968篇 |
1999年 | 1832篇 |
1998年 | 1072篇 |
1997年 | 1116篇 |
1996年 | 784篇 |
1995年 | 747篇 |
1994年 | 683篇 |
1993年 | 455篇 |
1992年 | 477篇 |
1991年 | 475篇 |
1990年 | 410篇 |
1989年 | 347篇 |
1988年 | 288篇 |
1987年 | 264篇 |
1986年 | 236篇 |
1985年 | 184篇 |
1984年 | 122篇 |
1983年 | 103篇 |
1982年 | 45篇 |
1981年 | 56篇 |
1980年 | 33篇 |
1979年 | 44篇 |
1978年 | 31篇 |
1977年 | 29篇 |
1976年 | 25篇 |
1973年 | 18篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
102.
103.
维生素D受体基因多态性与汉族人群慢性牙周炎易感性的关系 总被引:11,自引:0,他引:11
目的 探讨维生素D受体(VDR)基因多态性与汉族人群慢性牙周炎(CP)易感性的关系。方法 收集汉族轻、中、重度CP患者共166例及80名无牙周炎对照者的颊黏膜拭子,以Chelex-100法提取DNA,采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法测定VDR BsmI、VDR ApaI和VDR TaqI的基因型,分析组间基因型分布和等位基因频率的差异。结果 轻、中、重度CP患者中VDR ApaI等位基因A携带者明显多于对照组,重度CP与中度CP、重度CP与轻度CP患者间VDR ApaI基因型的分布差异均有统计学意义,中度CP与轻度CP患者间VDR ApaI基因型分布差异无统计学意义,而VDR BsmI、TaqI位点的基因型分布在患者组和对照组间差异无统计学意义。结论 VDR ApaI等位基因A可能与汉族人群CP的易感性有关。 相似文献
104.
105.
对于新病人。护理人员可为病人拟订护理计划并自己执行护理活动。但多数时间。护理人员是连续其他护理人员已执行的护理活动,因此交接班的好坏对护理质量有极大的影响。做好充分的交接班准备和一个能把握住重点的报告,可以得到真实完整的资料,使护理活动一开始就进入良好状况,保证原来护理工作的连续进行,提高护理质量。为此,2004年5月-2006年5月我科开始规范临床护理交接班工作,收到较好的效果。现将工作中存在问题进行分析并提出对策。 相似文献
106.
Expression of Anion Exchanger 1 Sequestrates p16 in the Cytoplasm in Gastric and Colonic Adenocarcinoma
下载免费PDF全文
![点击此处可从《Neoplasia (New York, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Wei-Wei Shen Jun Wu Li Cai Bing-Ya Liu Yan Gao Guo-Qiang Chen Guo-Hui Fu 《Neoplasia (New York, N.Y.)》2007,9(10):812-819
p16INK4A (p16) binds to cyclin-dependent kinase 4/6 and negatively regulates cell growth. Recent studies have led to an understanding of additional biologic functions for p16; however, the detailed mechanisms involved are still elusive. In this article, we show an unexpected expression of anion exchanger 1 (AE1) in the cytoplasm in poorly and moderately differentiated gastric and colonic adenocarcinoma cells and in its interaction with p16, thereby sequestrating the protein in the cytoplasm. Genetic alterations of p16 and AE1 were not detectable. Forced expression of AE1 in these cells sequestrated more p16 in the cytoplasm, whereas small interfering RNA-mediated silencing of AE1 in the cells induced the release of p16 from the cytoplasm to the nucleus, leading to cell death and growth inhibition of tumor cells. By analyzing tissue samples obtained from patients with gastric and colonic cancers, we found that 83.33% of gastric cancers and 56.52% of colonic cancers coexpressed AE1 and p16 in the cytoplasm. We conclude that AE1 plays a crucial role in the pathogenesis of gastric and colonic adenocarcinoma and that p16 dysfunction is a novel pathway of carcinogenesis. 相似文献
107.
Four Chinese patients (2 boys, 2 girls), ages 4–9 years, who had episodes of perception error of body schema and objects are reported. The metamorphopsia, which had been named Alice in Wonderland syndrome, is the major presentation. All of them were proved to have acute Epstein-Barr virus infection, as documented by positive heterophil antibody test and/or positive IgM antibody to Epstein-Barr virus capsid antigen. The duration of the perception disorder ranged from 1 week to 3 months. We believe that any young child presenting with Alice in Wonderland syndrome should undergo examination for Epstein-Barr virus infection; complete recovery from the disorder can be expected. 相似文献
108.
��״�ٹ��ܿ������״�ٹ��ܼ��͵���������� 总被引:2,自引:0,他引:2
沈永年 《中国实用儿科杂志》2006,21(11):813-815
1甲状腺功能亢进甲状腺功能亢进(甲亢)是指由于血循环中甲状腺素过多所造成的一种综合征。其病因常见有Graves'病(格雷夫斯病)又称毒性弥漫性甲状腺肿,新生儿甲状腺毒症(neonatal thyrotoxicosis),自身免疫性甲状腺炎,选择性T4抵抗综合征,功能自主性甲状腺结节,促甲状腺素(TSH)依赖性甲亢,激活TSH受体突变等。1.1Graves'病是一种甲状腺素分泌过多的器官特异性自身免疫性疾病,<5岁儿童较少见,大多发生于10岁以后,女性发病为男性5倍,60%病例有甲状腺疾病家族史。发生率每年约0·8/10万[1],病因尚不完全明确,大多数认为在遗传基础上因感染… 相似文献
109.
On genetic studies of bone loss. 总被引:3,自引:0,他引:3
Fang Yang Hui Shen Hui Jiang Hong-Wen Deng 《Journal of bone and mineral research》2006,21(11):1676-1677
110.
Chunjiang Tan Yuguang Li Xuerui Tan Hongxin Pan Wen Huang 《Clinical chemistry and laboratory medicine》2006,44(10):1218-1225
BACKGROUND: The ubiquitin-proteasome system (UPS) is thought to be functionally active in atherosclerosis (AS) lesions. Aspirin was found to be a potent inhibitor of the UPS in some tumour studies; however, its effect on AS remains to be demonstrated in vivo. METHODS: New Zealand rabbits were placed on a normal diet (N) or on a normal diet with aspirin (NI) or on an atherogenic diet without (H) or with aspirin (HI) for 12 weeks. Proteasome activity, concentrations of plasma lipids and levels of peroxidation were determined. Ubiquitin/ubiquitin-conjugates (Ub), IkappaBalpha, phosphorylated IkappaB (pIkappaBalpha) and p65 were investigated by Western blotting or immunochemistry. RESULTS: Concentrations of plasma lipids and peroxidation levels were higher in H or HI vs. N or NI. Histological analysis showed that atheroma was increased in H. Ub and IkappaBalpha were mainly localised in subendothelium and media vascular smooth muscle cells. Western blots revealed that Ub, IkappaBalpha, and pIkappaBalpha were increased, whereas p65 was lower in HI vs. H. The activity of the 20S proteasome was functionally active in H vs. N, NI or HI, while the 26S proteasome was not affected in any of the groups. CONCLUSIONS: Aspirin can attenuate the pathogenesis of atheroma formation, the degradation of IkappaBalpha and pIkappaBalpha, and lower the expression of p65, indicating that its therapeutic effects on AS may be via inhibition of the UPS. 相似文献