Lung cancer and prior tuberculosis infection in Shanghai

In a population-based case-control study of lung cancer in Shanghai involving interviews during 1984-86 with 1,405 cancer patients and 1,495 controls, a significant 50% elevation in the risk of lung cancer, adjusted for cigarette smoking, was observed among persons who had a history of tuberculosis. Among those diagnosed with tuberculosis within the past 20 years, the risk exceeded 2.5-fold. In males the lung cancers tended to occur on the same side as the previous tuberculosis infection. For both sexes, the effect of recent tuberculosis was most apparent for adenocarcinoma and peripheral tumours. No relationship was found between lung cancer risk and the type of tuberculosis therapy, including use of isoniazid. The findings suggest that tuberculosis may predispose to lung cancer, with the association most apparent among recent survivors of the infection.     

西辽河平原西北侧低山丘陵黄鼠疫源地的发现与研究

1985年首次从西辽河平原西北侧低山丘陵草原的达乌尔黄鼠及寄生蚤方形黄鼠蚤松江亚种检出4株鼠疫杆菌,到1989年共检出鼠疫菌57株,判定疫点47个。1985～1991年共检出达乌尔黄鼠鼠疫阳性血清271份,阳性率3.44％,几何平均滴度为1:99.17。疫点和血凝阳性点的空间分布约3000km~2。疫源地的主要宿主为达乌尔黄鼠,主要媒介为方形黄鼠蚤松江亚种。动物鼠疫的流行呈单峰型,流行高峰时点在5月17日,1987年为流行高峰年,坡麓为该鼠疫疫源地的频发生境。     

高血压患者左室构型和房性心律失常的关系

目的了解高血压患者左室构型和房性心律失常关系。方法应用超声心动图及动态心电图，测定左室结构及房性心律失常发生率。结果Ｋｌｅｉｇｅｒ３～６发生和构型有联系（Ｐ＜０．００１）。结论左室构型影响房性心律失常。     

Molecular cytogenetic study of short arm aberrations in human D, G group chromosomes.

Six cases of Dp+/Gp+, 10 cases of D/G translocation, 1 case of supernumerary marker chromosome, and 1 case of Yqs were studied using molecular and cytogenetic techniques. The Ag-NOR frequencies of the Dp+ and Gp+ groups were found to be higher than those of normal controls, while their satellite association frequencies were lower. Autoradiographic silver grains were not significantly distributed along the p+ part of the marker chromosome as revealed by chromosomal in situ hybridization using an rRNA probe. This result differs from our previous report. It is suggested that there might be different mechanisms for the formation of p+ on acrocentric chromosomes. D/G translocation cases were found to have lost their NOR. A study of supernumerary marker chromosomes and Yqs cases suggested that the marker chromosome and Yqs exerted no phenotypic effect. The mechanism of their formation is discussed.     

胎儿耳廓弹性软骨及其组织的发生

用９周－３９周引产胎儿标本７２例，取右耳廓石蜡切片，ＨＥ和Ｗｅｉｔｅｒｔ弹性纤维染色，光镜观察其弹性软骨、弹性纤维、耳廓肌和结缔组织的发生。     

玻璃纤维诱导的转化细胞活化癌基因的研究

用玻璃纤维处理BALB/C3T3细胞,使细胞发生转化,从转化细胞中抽提DNA用以转染NIH3T3细胞,结果被转染的细胞亦发生转化。用~(32)P标记的Ha-ras癌基因作探针,通过斑点杂交,征明玻璃纤维诱发的BALB/3T3转化细胞中,Ha—ras的原癌基因被激活。     

准分子激光冠状动脉成形术的初步临床应用经验

目的：介绍准分子激光冠状动脉成形术（ＥＬＣＡ）治疗冠状动脉狭窄的临床应用经验。材料和方法：１０例冠心病患者作冠状动脉造影确认有１４支冠状动脉狭窄（狭窄率７０％～７５％者５支，９０％～１００％者９支）。全部病例均作ＥＬＣＡ手术。ＥＬＣＡ采用脉冲间期为１８０－２２０ｍｓｅｃ，光导纤维直径为１．３～１．６ｍｍ，能量密度１４．５～２１．０ｍＪ，激光频率为２０Ｈｚ。ＥＬＣＡ术后辅以球囊扩张血管成形术（ＰＴＣＡ）。结果：９例１３支狭窄动脉中，９支狭窄率＞９０％者，作ＥＬＣＡ＋ＰＴＣＡ成功，其中７支动脉狭窄率减至１５％以下，２支减至４０％～４５％，１例因术中导丝头断裂，失败。成功的９支动脉术后冠状动脉造影示：内膜光滑４支，毛糙３支，夹层动脉瘤１支（２月后随访消失），术中出现血栓１支。术后６个月内造影随访，３例动脉再度狭窄。结论：准分子激光冠状动脉成形术可用于ＰＴＣＡ难以成功的有钙化硬斑、挟窄段较长（＞２．０ｃｍ）和闭塞的冠状动脉，安全有效。但它并不能避免术后再狭窄的发生。     

苏乐康等抑制细胞转化能力及其机制的探讨

研究了苏乐康、绿茶提取物对~(60)钴γ射线和雌性激素联合诱发叙利亚金黄地鼠胚胎细胞恶性转化的抑制能力,并用脉冲辐解技术,对其抑制机制进行初步探讨。实验结果表明,苏乐康、绿茶提取物对γ射线和雌性激素联合诱发的金黄地鼠胚胎细胞恶性转化的抑制率分别为70.15％(P<0.05)和81.59％(P<0.05),它们的这种抑制能力与其清除超氧阴离子的能力有关,     

阿霉素磁性明胶微球的研究

报告了阿霉素磁性明胶微球（Ａｄｒ－ＭＧ－ｍｓ）的制备与性质，研究了超细氧化铁粒子的合成和磁性明胶微球（ＭＧ－ｍｓ）在狗体内的栓塞效果。阿霉素磁性明胶微球由２％阿霉素（Ａｄｒ）、６８％明胶和３０％的磁铁粒子组成，微球的平均粒径为２２μｍ。在体外实验中，药物释放速度证明微球有缓释的性质。磁铁粒子的平均粒径约为１０ｎｍ，磁性明胶微球与￣（９９ｍ）Ｔｃ标记磁性明胶微球通过导管分别输入狗的肝动脉内进行栓塞，照相和血管造影显示在未加外磁场时磁性明胶微球在左右肝叶分布几乎相等，而在１２００高斯的外磁场作用下，靶部位肝左叶的微球分布是肝右叶的２．２５倍，而甲状腺、脑、心脏的微球很微量，结果表明磁性明胶微球在外磁场作用下是一个很好的治疗肝癌的栓塞剂。