Surgical management of large and giant cavernous sinus hemangiomas

Cavernous sinus hemangiomas (CSH) are rare vascular tumors within the cavernous sinus. Gamma Knife radiosurgery (GKS) is less effective for large and giant CSH than for smaller ones. In one of the largest single-institution series reported thus far, we present 22 patients with large (3–4 cm-diameter, six patients) and giant (>4 cm, 16 patients) CSH treated surgically between 1994 and 2011. We also review related reports published since 1999 and further compare the treatment outcomes of surgery and radiosurgery. In the present study, a modified Dolenc’s epidural approach was performed in 18 patients and the intradural approach was used in four. Gross total or near-total resection was achieved in 18 patients, subtotal resection was achieved in three patients and partial resection was achieved in one patient. Postoperative ophthalmoparesis occurred in seven patients (two improved, four unchanged to preoperative, one new deficit), and decreased visual acuity occurred in one patient. The reviewed literature and our experience suggest that surgical treatment of large and giant CSH is a reasonable option. A relatively low postoperative morbidity can be achieved with minimal disturbance of cranial nerve (CN) III, particularly with early localization and preservation of CN VI. GKS could be an adjunct treatment for residual tumor.     

The structural composition of components contributes to the superiority of the geoherb Alisma orientale for “diuresis and diffusing dampness”

The purpose of this study is to explore the intrinsic reasons for the superiority of the salt-made geoherb Alisma orientale via comparing the content of various components of the salt-made geoherb Alisma orientale. The effects of “diuresis and diffusing dampness” using salt-made Alisma orientale from seven different origins were investigated through pharmacodynamic experiments in vivo and in vitro. The results indicated that salt-made Alisma orientale from different origins had diuretic efficacy; this was demonstrated by the significant increase in the volume of rat urine, the concentration of Na⁺, K⁺, and Cl⁻ in the urine, and the significant decrease in the levels of AQP-2 in rat renal medulla and HK-2 cells. It was also revealed that the diuretic effect of salt-made Alisma orientale from Fujian Province is stronger than those from other provinces. Moreover, the main components and their proportions in the salt-made Alisma orientale samples were further analyzed via principal component analysis. The results showed that alisol A 24-acetate, alisol B, and 23-acetyl alisol B are the main components of salt-made Alisma orientale, and the optimal structural ratio of alisol A 24-acetate, alisol B, and 23-acetyl alisol B was found to be 5.38 : 14.34 : 11.31 via optimizing the ratios of the three main components. It is worth noting that the optimal ratio of the three main components after optimization is the closest to the ratio of the three main components in salt-made Alisma orientale from Fujian Province. This paper reveals the “mystery” of the content ratio of the main active components and its effect on the efficacy, and showed that the proportional relationship between the content of multiple components is the key to their interactions. Therefore, this method of evaluating the quality of salt-made Alisma orientale is obviously reliable, and this study lays the foundations for quality evaluation of salt-made Alisma orientale and other herb slices.

The purpose of this study is to explore the intrinsic reasons for the superiority of the salt-made geoherb Alisma orientale via comparing the content of various components of the salt-made geoherb Alisma orientale.     

Comparison of methods for isolating primary hepatocytes from mini pigs

Successful porcine hepatocyte isolation is crucial for the development of bioartificial liver devices and hepatocyte transplantation. Serva collagenase NB grades are formulated collagenases that are suitable for various tissue isolation applications. N‐acetylcysteine (NAC) can improve the viability of human hepatocytes. The aim of this study was to compare the effectiveness of two collagenases and effect of NAC on hepatocyte isolation from porcine liver tissue. Porcine hepatocytes were isolated using the perfusion method from Bama mini pigs assigned to the Serva NB 4 group (n=6), the Serva NB 8 group (n=6), or the NB 8+NAC group (n=6). Viability and yield were defined as fresh hepatocytes and their spheroids formation after 24‐hour rocker culture in serum‐free medium. Metabolic function was assessed by gene expression, albumin, and urea synthesis. All procedures resulted in successful hepatocyte isolation. Cells from the NB 8+NAC group had (97.8±1.9)% viability, which was higher than the NB 8 group with (94.4±2.4)% and the NB 4 group with (94.5±3.2)% (P<.001). The final cell yield reached (11.8±1.0)×10⁹ cells in the NB 8+NAC group, compared to (9.5±2.1)×10⁹ cells in the NB 8 group (P<.01) and (9.1±1.1) ×10⁹ cells in the NB 4 group (P<.001). The secretion of albumin was superior in the NB 8+NAC group at a concentration of (425.8±35.3) ng/mL compared to the NB 8 group (339.1±32.6) ng/mL (P <.001) and NB 4 group (293.6±43.3) ng/mL (P <.01). The injury of hepatocytes also decreased in the NB 8+NAC group (P<.01). The data are presented as means ± SD. Formulated collagenase Serva NB 8 and NAC could improve the porcine hepatocyte isolation, resulting in higher yields of viable cells.     

Effects of the modified excision combined with bidirectional photodynamic therapy on refractory hidradenitis suppurativa: a retrospective study

Lasers in Medical Science - To describe the clinical features of refractory hidradenitis suppurativa (HS) patients (Hurley stageII and stage III) and evaluate the efficacy of combined treatment of...     

Comparative study of testicular volume in children with unilateral cryptorchidism of different ages in the tropical province of China

Objective

To assess the testicular volume in children with unilateral cryptorchidism of different ages in Hainan Province, China.

Methods

The study included 424 children (ranging in age from 0 month to 4 years) with unilateral cryptorchidism or normal who were treated from 2017 to 2021 at our institution. They were divided into different groups according to age. We evaluated the correlation of testicular volume between the children with cryptorchidism and the normal children among different groups.

Results

There was a significant difference in testicular volume between the affected side and the healthy side. There was no difference in testicular volume between the left side and the right side of each control group. There were significant differences between the affected side of cryptorchid groups and the same side of the control groups. There were no significant differences between the healthy side of cryptorchid groups and the same side of the control groups. There were no significant differences between the affected side of left cryptorchid groups and right cryptorchid groups. There were no significant differences between the healthy side of left cryptorchid groups and right cryptorchid groups. There were significant differences in testicular volume among different age groups of the control group, while there were no differences in the cryptorchid groups.

Conclusions

The development of testicular volume in children with unilateral inguinal cryptorchidism is affected in earlier age, and there was no compensatory testicular adaptation in the healthy testis.

     

Development of a New Index Based on Preoperative Serum Lipocalin 2 to Predict Post-LSG Weight Reduction

Obesity Surgery - Bariatric surgery is the most effective therapy for obesity, but targeted weight reduction is not always achieved. Serum lipocalin-2 (LCN2) is closely associated with obesity, but...     

肺功能氧合指标监测在呼吸道管理中的应用

目的探讨肺功能氧合指标监测对呼吸系统各种病理变化的改善作用。方法通过采集到动脉血、混合静脉血来进行血气分析,对60例存在呼吸道疾病的患者实施肺功能氧合指标监测,并运用氧合计算软件进行计算,根据各指标数值变化建立有效呼吸道管理方案,并对护理干预前后的效果进行比较。结果各个氧合数值与各种呼吸道疾患存在密切的联系;在实施有效的气道护理措施后,本组60例患者各氧合指标数值都有显著改善,整体有效率达43.3%,与护理干预前比差异有统计学意义（P〈0.01）。结论肺功能氧合指标可以及时、准确地反映呼吸系统早期病理变化,以监测的各氧合指标数值为依据,可指导临床及早建立有效呼吸道管理方案。     

Kümmell病的临床治疗进展

目的:系统评价自体骨移植与骨形成蛋白治疗成人长骨骨折不愈合相关指标,为成人长骨骨折不愈合治疗提供参考依据。方法:计算机检索PuMed、Embase、Cochrane图书馆、中国知网(CNKI)、万方数据期刊全文数据库及中国生物医学文献数据库(CBM)发表的对于自体骨移植与骨形成蛋白治疗成人长骨骨折不愈合的随机对照试验,检索时间从建库至2019年3月。由2名研究者按照纳入和排除标准独立进行筛选文献,提取资料,并采用Jadad评价量表对纳入的文献进行质量评价。采用RevMan 5.3统计学软件对两种方法的感染发生率、成功愈合率、二次手术率、住院时间及术中失血量进行Meta分析。结果:共纳入7个随机对照试验研究,共652例患者,自体骨移植组有410例,骨形成蛋白组有242例。Meta分析结果显示:自体骨移植组与骨形成蛋白组在感染发生率[RR=1.32,95%CI(0.90,1.93),P=0.16],成功愈合率[RR=0.95,95%CI(0.84,1.08),P=0.43],二次手术率[RR=1.16,95%CI(0.43,3.12),P=0.76]及住院时间[MD=0.69,95%CI(-0.38,1.75),P=0.21]方面比较差异无统计学意义。自体骨移植组术中失血量明显高于骨形成蛋白组[MD=223.00,95%CI(32.72,413.28),P=0.02]。结论:对于成人长骨骨折不愈合的治疗,骨形成蛋白可以获得和自体骨移植一样的骨折愈合率,同时可以明显减少术中失血量。骨形成蛋白可能更适合成人长骨骨折不愈合的治疗。