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131.
132.
目的 观察注射用益气复脉治疗急性分水岭脑梗死的临床效果.方法 80例急性分水岭脑梗死患者完全随机分为观察组(40例),对照组(40例).2组均给予抗血小板聚集、调脂、调控血压、改善微循环及保护脑细胞等治疗,观察组在此基础上加用注射用益气复脉,5.2 g/d静脉滴注,共10 d.治疗前后应用美国国立卫生研究院卒中量表(NIHSS)进行神经功能缺损评分.结果 2组患者治疗后NIHSS评分均低于本组治疗前[观察组(8.4±2.5)分比(13.2±2.3)分,对照组(9.6±3.2)分比(13.4±2.7)分],观察组治疗后NIHSS评分明显低于对照组(P<0.05).观察组治疗有效率为85.0%(34/40),明显高于对照组的65.0% (26/40)(P<0.05).2组均无明显不良反应.结论 注射用益气复脉治疗分水岭脑梗死安全、有效. 相似文献
133.
Carbon fiber reinforced thermosetting polyimide (CF/TSPI) composites were interleaved with thermally stable thermoplastic polyimide (TPPI) fiber veils in order to improve the interlaminar fracture toughness without sacrificing the heat resistance. Both of the mode I and mode II interlaminar fracture toughness (GIC and GIIC) for the untoughened laminate and TPPI fiber veils interleaved laminates were characterized by the double cantilever beam (DCB) test and end notch flexure (ENF) test, respectively. It is found that the TPPI fiber veils interleaved laminates exhibit extremely increased fracture toughness than the untoughened one. Moreover, the areal density of TPPI greatly affected the fracture toughness of laminates. A maximum improvement up to 179% and 132% on GIC and GIIC is obtained for 15 gsm fiber veils interleaved laminate, which contributes to the existence of bicontinuous TPPI/TSPI structure in the interlayer according to the fractography analysis. The interlaminar fracture behavior at elevated temperatures for 15 gsm fiber veils interleaved laminate were also investigated. The results indicated that the introduction of thermally stable TPPI fiber veils could enhance the fracture toughness of CF/TSPI composites by exceeding 200% as compared to the untoughened one even as tested at 250 °C. 相似文献
134.
Yinghua Wang Xinming Zhai Minfang Zhu Yan Pan Min Yang Kaiyan Yu Ben He 《Journal of thoracic disease》2021,13(4):2486
BackgroundThe current study aimed to investigate the incidence of sepsis-induced cardiomyopathy (SICM) in patients who received general thoracic surgery, along with the risk factors and management strategies for this complication.MethodsThe clinical records of 163 patients with postoperative sepsis were retrospectively reviewed. After propensity score matching, 144 patients were divided into 2 groups by stroke volume: the SICM group (n=72) and the non-SICM group (n=72).ResultsThe overall incidence of postoperative SICM was 53.99%. Multiple logistic regression analysis showed that stroke volume and C-reactive protein were independent predictors of mortality in patients with postoperative sepsis. Statistical analysis by t-test and χ2 test indicated that mortality (P=0.000), B-type natriuretic peptide (P=0.001), left ventricular ejection fraction (P=0.000), the mitral peak velocity of early filling/early diastolic mitral annular velocity (E/e’) (P=0.049), C-reactive protein (P=0.016), procalcitonin (P=0.013), serum creatinine (P=0.016), platelets (P=0.028), and lactic acid (P=0.002) were significantly associated with the occurrence of postoperative SICM. Among these parameters, B-type natriuretic peptide was identified as the best biomarker for predicting SICM by receiver operating characteristic (ROC) curve analysis.ConclusionsIt is vital to improve the diagnosis and standard management of SICM. A combined strategy comprising early detection of suspected infection, adequate use of antibiotics, close monitoring, effective drainage, and supportive care may improve the outcomes of patients with postoperative SICM. 相似文献
135.
Bo Jia Qiwen Zheng Jianjie Li Jun Zhao Meina Wu Tongtong An Yuyan Wang Minglei Zhuo Xue Yang Hanxiao Chen Yujia Chi Jingjing Wang Xiaoyu Zhai Yuling He Lingdong Kong Ziping Wang 《Journal of thoracic disease》2021,13(3):1799
BackgroundThis study aimed to assess the different survival outcomes of stage I–IIIA non-small cell lung cancer (NSCLC) patients who received right-sided and left-sided pneumonectomy, and to further develop the most appropriate treatment strategies.MethodsWe accessed data from the Surveillance, Epidemiology, and End Results database from the United States for the present study. An innovative propensity score matching analysis was used to minimize the variance between groups.ResultsFor 2,683 patients who received pneumonectomy, cancer-specific survival [hazard ratio (HR) =0.863, 95% confidence interval (CI): 0.771 to 0.965, P=0.010] and overall survival (OS; HR =0.875, 95% CI: 0.793 to 0.967, P=0.008) were significantly superior in left-sided pneumonectomy patients compared with right-sided pneumonectomy patients. Cancer-specific survival (HR =0.847, 95% CI: 0.745 to 0.963, P=0.011) and OS (HR =0.858, 95% CI: 0.768 to 0.959, P=0.007) were also significantly longer with left-sided compared to right-sided pneumonectomy after matching analysis of 2,050 patients. Adjuvant therapy could significantly prolong cancer-specific survival (67 versus 51 months, HR =1.314, 95% CI: 1.093 to 1.579, P=0.004) and OS (46 versus 30 months, HR =1.458, 95% CI: 1.239 to 1.715, P<0.001) among left-sided pneumonectomy patients after the matching procedure, while adjuvant therapy did not increase cancer-specific survival for right-sided pneumonectomy patients (46 versus 42 months, HR =1.112, 95% CI: 0.933 to 1.325, P=0.236). Subgroup analysis showed that adjuvant chemotherapy could significantly improve cancer-specific survival and OS for all pneumonectomy patients. However, radiotherapy was associated with worse survival for patients with right-sided pneumonectomy.ConclusionsPneumonectomy side can be deemed as an important factor when physicians determine the most optimal treatment strategies. 相似文献
136.
Yuanming Zhai Pengchi Deng Xiaoyan Wang Chunchun Zhang Ruixue Gan Na Gan Qiaomei Sun Hui Li 《RSC advances》2018,8(55):31555
The interaction mechanism between olaparib (OLA) and human serum albumin (HSA) has been investigated using experimental and computational techniques. An NMR relaxation approach based on the analysis of proton selective and non-selective spin–lattice relaxation rates at different temperatures can provide quantitative information about the affinity index and the thermodynamic equilibrium constant of the OLA–HSA system. The affinity index and the thermodynamic equilibrium constant decreased as temperature increased, indicating that the interactions between OLA and HSA could be weakened as temperature increased. Molecular docking and dynamics simulations revealed that OLA stably bound to subdomain II (site 1), and OLA could induce the conformational and micro-environmental changes in HSA. CD results suggested that α-helix content decreased after OLA was added, demonstrating that OLA affected the secondary structure of HSA.The interaction mechanism between olaparib (OLA) and human serum albumin (HSA) has been investigated using experimental and computational techniques. 相似文献
137.
138.
A simple method for the preparation of porous nitrogen-doped carbon spheres (MNCS) with honeycomb-like structures through the self-assembly of colloidal silica by using polyaniline as the nitrogen source and a carbon precursor is reported. The BET surface area calculated from N2 adsorption/desorption measurement of the MNCS is up to 882 m2 g−1. The synthesized MNCS were employed as a support for Pt nanoparticles for the oxidation of methanol and ethanol in alkaline media. Compared to Pt supported on commercial Vulcan XC-72R carbon (Pt/C), Pt/MNCS exhibit higher electro-catalytic performance and greater stability, indicating that MNCS have potential application prospects as electro-catalyst supports for alcohol oxidation in alkaline media. This enhancement in performance is due to the honeycomb-like porous structure of the MNCS and the doping with nitrogen.We synthesized honeycomb-like porous nitrogen-doped carbon spheres, which can be used as support of Pt for alcohol oxidation. 相似文献
139.
Zhai G Cicuttini F Srikanth V Cooley H Ding C Jones G 《Arthritis and rheumatism》2005,52(4):1069-1076
OBJECTIVE: To compare associations between anthropometric and lifestyle factors and femoral head cartilage volume/thickness and radiographic features of osteoarthritis (OA) and to provide evidence of construct validity for magnetic resonance imaging (MRI) assessment of femoral cartilage volume and thickness. METHODS: We studied a cross-sectional sample of 151 randomly selected subjects (79 men, 72 women; mean age 63 years) from the Tasmanian Older Adult Cohort Study. A sagittal T1-weighted fat-suppression MRI scan of the right hip was performed to determine femoral head cartilage volume, cartilage thickness, and size. An anteroposterior radiograph of the pelvis with weight bearing was performed and scored for radiographic evidence of OA in the right hip. Other factors measured were height, weight, leg strength, serum vitamin D levels, and bone mineral density. RESULTS: Hip cartilage volume was significantly associated with female sex, body mass index, and femoral head size, whereas hip cartilage thickness was significantly associated only with the size of the femoral head. Only female sex was significantly associated with the total radiographic OA score and the joint space narrowing (JSN) score, but not the osteophyte score. Radiographic JSN of the hip, especially axial JSN (but not osteophytes), was significantly correlated with hip cartilage volume and thickness. CONCLUSION: Femoral head cartilage volume and thickness have modest but significant construct validity when correlated with radiographic findings. Furthermore, the generally stronger associations with volume compared with radiographic OA suggest that MRI may be superior at identifying risk factors for hip OA. 相似文献
140.
糖尿病对骨密度及相关激素的影响 总被引:5,自引:0,他引:5
目的 观察DM患者骨密度(bone mineral density,BMD)及其相关激素的改变,并探讨其发生机制。方法 采用双能(线吸收法测量2型DM患者68例、1型DM患者54例和健康人62例的BMD,放免法测定血清骨钙素、降钙素和25羟维生素D3,免疫放射法测定血清完整甲状旁腺素及I型胶原羧基末段前肽。结果 ①两组DM患者全血HbA1c水平均显著高于对照组(P<0.01),血清骨钙素水平显著低于对照组(P<0.01);②2型DM组BMI、大转子BMD显著高于对照组和1型DM组(BMI,P<0.01;BMD,P<0.05);1型DM组股骨颈BMD低于对照组和2型DM组(P<0.05),经BMI纠正后,1型DM组股骨颈BMD仍低于对照组(P<0.05);③1型DM组各位点BMD与血清I型胶原羧基末段前肽水平呈负相关(P<0.05),2型DM组腰椎和大转子BMD与全血HbA1c水平呈负相关(P<0.05)。结论 与健康人群相比,1型DM患者BMD明显降低,2型DM患者BMD明显增高,但经BMI纠正后,这种差异性消失;骨转化降低以及糖尿病代谢紊乱可能参与了糖尿病骨质疏松的发生。 相似文献