全文获取类型
收费全文 | 2928篇 |
免费 | 176篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 210篇 |
妇产科学 | 52篇 |
基础医学 | 276篇 |
口腔科学 | 64篇 |
临床医学 | 217篇 |
内科学 | 591篇 |
皮肤病学 | 128篇 |
神经病学 | 234篇 |
特种医学 | 37篇 |
外科学 | 417篇 |
综合类 | 38篇 |
一般理论 | 4篇 |
预防医学 | 122篇 |
眼科学 | 139篇 |
药学 | 318篇 |
中国医学 | 15篇 |
肿瘤学 | 219篇 |
出版年
2023年 | 12篇 |
2022年 | 45篇 |
2021年 | 95篇 |
2020年 | 61篇 |
2019年 | 84篇 |
2018年 | 117篇 |
2017年 | 87篇 |
2016年 | 95篇 |
2015年 | 87篇 |
2014年 | 134篇 |
2013年 | 163篇 |
2012年 | 230篇 |
2011年 | 226篇 |
2010年 | 165篇 |
2009年 | 109篇 |
2008年 | 205篇 |
2007年 | 177篇 |
2006年 | 154篇 |
2005年 | 168篇 |
2004年 | 180篇 |
2003年 | 123篇 |
2002年 | 107篇 |
2001年 | 32篇 |
2000年 | 24篇 |
1999年 | 19篇 |
1998年 | 36篇 |
1997年 | 19篇 |
1996年 | 23篇 |
1995年 | 19篇 |
1994年 | 12篇 |
1993年 | 7篇 |
1992年 | 9篇 |
1991年 | 19篇 |
1990年 | 6篇 |
1989年 | 9篇 |
1988年 | 5篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1984年 | 3篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有3112条查询结果,搜索用时 10 毫秒
81.
Naomi Holman PhD Peter Knighton MPhys Jackie OʼKeefe MSc Sarah H. Wild PhD Sarah Brewster MRCP Hermione Price FRCP Kiran Patel PhD Wasim Hanif MD Vinod Patel MD Edward W. Gregg PhD Richard I. G. Holt PhD Roger Gadsby MB Kamlesh Khunti MD Jonathan Valabhji MD Bob Young MD Naveed Sattar MD 《Diabetes, obesity & metabolism》2021,23(12):2728-2740
82.
Pal Minakshi Kumar Vinod Yadav Rakesh Gulati Deepika Yadav R. C. 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(3):775-784
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Plants are a rich source of valuable chemicals that are used as herbal and modern medicines. Shikonin, a... 相似文献
83.
Predictors of recurrence following catheter ablation of atrial fibrillation using an irrigated-tip ablation catheter 总被引:10,自引:0,他引:10
Vasamreddy CR Lickfett L Jayam VK Nasir K Bradley DJ Eldadah Z Dickfeld T Berger R Calkins H 《Journal of cardiovascular electrophysiology》2004,15(6):692-697
INTRODUCTION: The aims of this study were to identify predictors of recurrence after catheter ablation of atrial fibrillation (AF) and to report the safety and efficacy of catheter ablation of AF using an irrigated-tip ablation catheter. METHODS AND RESULTS: Seventy-five consecutive patients (51 men [68%]; age 54 +/- 13 years) with symptomatic drug-refractory paroxysmal (42 patients), persistent (21 patients), or permanent (12 patients) AF underwent catheter ablation of AF using an irrigated-tip ablation catheter and a standard ablation strategy, which involved electrical isolation of all pulmonary veins (PVs) and creation of a cavotricuspid linear lesion. At 10.5 +/- 7.5 months of follow-up following a single (n = 75) or redo ablation procedure (n = 11), 39 (52%) of the 75 patients were free of AF, 10 were improved (13%), and 26 had experienced no benefit from the ablation procedure (35%). Seventy-six percent of patients with paroxysmal AF were free from recurrent AF. The most significant complications were two episodes of pericardial tamponade, mitral valve injury in one patient, two strokes, and complete but asymptomatic PV stenosis in one patient. Cox proportional hazards multivariate regression analysis identified the presence of persistent AF, permanent AF, and age >50 years prior to the ablation are the only independent predictors of AF recurrence after the first PV isolation procedure. CONCLUSION: Catheter ablation of AF using a strategy involving isolation of all PVs and creation of a linear lesion in the cavotricuspid isthmus using cooled radiofrequency energy is associated with moderate efficacy and an important risk for complications. The best results of this procedure are achieved in the subset of patients who are younger than 50 years and have only paroxysmal AF. 相似文献
84.
Differentiating Psoriatic Arthritis From Psoriasis Without Psoriatic Arthritis Using Novel Serum Biomarkers 下载免费PDF全文
Daniela Cretu Lisa Gao Kun Liang Antoninus Soosaipillai Eleftherios P. Diamandis Vinod Chandran 《Arthritis care & research》2018,70(3):454-461
Objective
There is a high prevalence of undiagnosed psoriatic arthritis (PsA) in patients with psoriasis. Identifying soluble biomarkers for PsA will help in screening psoriasis patients for appropriate rheumatology referral. We therefore aimed to investigate whether serum levels of novel markers previously discovered by quantitative mass spectrometric analysis of synovial fluid and skin biopsies performs better than the C‐reactive protein (CRP) level in differentiating PsA patients from those with psoriasis without PsA (PsC).Methods
In this case–control study, serum samples were obtained from 100 subjects with PsA, 100 with PsC, and 100 healthy controls. Patients with PsA and PsC were group matched for age, sex, psoriasis duration, and Psoriasis Area and Severity Index and were not currently receiving biologic treatment. Using enzyme‐linked immunosorbent assay, 4 high‐priority markers (Mac‐2‐binding protein [M2BP], CD5‐like protein [CD5L], myeloperoxidase [MPO], and integrin β5 [ITGβ5]), as well as previously established markers (matrix metalloproteinase 3 [MMP‐3] and CRP level) were assayed. Data were analyzed using logistic regression. Receiver operating characteristic (ROC) curves were plotted.Results
In comparisons to controls, CD5L, ITGβ5, M2BP, MPO, MMP‐3, and CRP level were independently associated with PsA, while only CD5L, M2BP, and MPO were independently associated with PsC alone. In comparisons to PsC, ITGβ5, M2BP, and CRP level were independently associated with PsA. ROC analysis of this model shows an area under the curve (AUC) of 0.85 (95% confidence interval [95% CI] 0.80–0.90). The model that included CRP level alone had an AUC of 0.71 (95% CI 0.64–0.78).Conclusion
CD5L, ITGβ5, M2BP, MPO, MMP‐3, and CRP level are markers for PsA. The combination of ITGβ5, M2BP, and CRP level differentiates PsA from PsC, and performs better than CRP level alone.85.
Lauren S. Tufts Emma D. Jarnagin Jessica R. Flynn Mithat Gonen Jose G. Guillem Philip B. Paty Garrett M. Nash Joshua J. Smith Iris H. Wei Emmanouil Pappou Michael I. DAngelica Peter J. Allen T. Peter Kingham Vinod P. Balachandran Jeffrey A. Drebin Julio Garcia-Aguilar William R. Jarnagin Martin R. Weiser 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2019,21(2):181-186
Background
Surgical site infections (SSIs) are a major cause of morbidity, mortality, and healthcare costs, and patients undergoing simultaneous colorectal/liver resections are at an especially high SSI risk.Methods
Data were collected on all patients undergoing synchronous colorectal/liver resection from 2011 to 2016 (n = 424). The intervention, implemented in 2013, included 13 multidisciplinary perioperative components. The primary endpoints were superficial/deep and organ space SSIs. Secondary endpoints were hospital length of stay (LOS) and 30-day readmission rate. To control for changes in SSI rates independent of the intervention, interrupted time series analysis was conducted.Results
Overall, superficial/deep, and organ space SSIs decreased by 60.5% (p < 0.001), 80.6% (p < 0.001), and 47.6% (p = 0.008), respectively. In the pre-intervention cohort (n = 231), there were 79 (34.2%), 31 (13.4%), and 48 (20.8%) total, superficial/deep, and organs space SSIs, respectively. In the post-intervention cohort (n = 193), there were 26 (13.5%), 5 (2.6%), and 21 (10.9%) total, superficial/deep, and organs space SSIs, respectively. Median LOS decreased from 9 to 8 days (p < 0.001). Readmission rates did not change (p = 0.6). Interrupted time series analysis found no significant trends in SSI rate within the pre-intervention (p = 0.35) and post-intervention (p = 0.55) periods.Conclusion
In combined colorectal/liver resection patients, implementation of a multidisciplinary care bundle was associated with a 61% reduction in SSIs, with the greatest impact on superficial/deep SSI, and modest reduction in LOS. The absence of trends within each time period indicated that the intervention was likely responsible for SSI reduction. Future efforts should target further reduction in organ space SSI. 相似文献86.
87.
88.
89.
Sudha Sazawal Rekha Chaubey Pawandeep Kaur Sunita Chikkara Bijender Kumar Sameer Bakshi L. S. Arya Vinod Raina Alakananda Das Gupta Renu Saxena 《Indian journal of hematology & blood transfusion》2014,30(4):219-225
Genetic polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) gene have been associated with the development of acute leukemias and various malignancies. The role of MTHFR polymorphism in the development of pediatric acute lymphoblastic leukemia (ALL) has been extensively studied among north Indians in various settings, yet its association with acute leukemias remains unresolved. To evaluate the relationship between functional MTHFR polymorphisms, C677T and A1298C and possible effect on risk of ALL in adults and children in North Indian population by comparing them with healthy controls. DNA was isolated from peripheral blood of 184 ALL patients (33 adults, 151 children) and 155 controls and analyzed by a PCR-restriction fragment length polymorphism assay. The frequency of MTHFR 677CT and 1298 AC genotypes were significantly lower among adult ALL cases when compared to the controls. We found a 1.74-fold reduced risk of ALL in individuals with 1298AC polymorphic variant and a 9.17-fold decreased risk of adult ALL. However, no statistically significant difference was evident between the above polymorphisms and susceptibility to ALL in children. Polymorphisms in the MTHFR gene possibly modulate risk of ALL in north Indian adults but not in children, although larger studies are needed. 相似文献
90.