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951.
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953.
Vivilaki VG Dafermos V Gevorgian L Dimopoulou A Patelarou E Bick D Tsopelas ND Lionis C 《Women & health》2012,52(4):369-390
The Maternal Adjustment and Maternal Attitudes Scale is a self- administered scale, designed for use in primary care settings to identify postpartum maternal adjustment problems regarding body image, sex, somatic symptoms, and marital relationships. Women were recruited within four weeks of giving birth. Responses to the Maternal Adjustment and Maternal Attitudes Scale were compared for agreement with responses to the Edinburgh Postnatal Depression Scale as a gold standard. Psychometric measurements included: reliability coefficients, explanatory factor analysis, and confirmatory analysis by linear structural relations. A receiver operating characteristic analysis was carried out to evaluate the global functioning of the scale. Of 300 mothers screened, 121 (40.7%) were experiencing difficulties in maternal adjustment and maternal attitudes. Scores on the Maternal Adjustment and Maternal Attitudes Scale correlated well with those on the Edinburgh Postnatal Depression Scale. The internal consistency of the Maternal Adjustment and Maternal Attitudes Scale, Greek version-tested using Cronbach's alpha coefficient-was 0.859, and that of Guttman split-half coefficient was 0.820. Findings confirmed the multidimensionality of the Maternal Adjustment and Maternal Attitudes Scale, demonstrating a six-factor structure. The area under the receiver operating characteristic curve was 0.610, and the logistic estimate for the threshold score of 57/58 fitted the model sensitivity at 68% and model specificity at 64.6%. Data confirmed that the Greek version of the Maternal Adjustment and Maternal Attitudes Scale is a reliable and valid screening tool for both clinical practice and research purposes to detect postpartum adjustment difficulties. 相似文献
954.
Ourania Nicolatou-Galitis Pavlina Athanassiadou Vassilis Kouloulias Anastasia Sotiropoulou-Lontou Konstantinos Dardoufas Argy Polychronopoulou Maria Gonidi Konstantinos Kyprianou Georgia Kolitsi Christos Skarleas George Pissakas Ioannis S. Papanikolaou John Kouvaris 《Supportive care in cancer》2006,14(7):753-762
Goal of work The aim of the study was to investigate the incidence of herpes simplex virus-1 (HSV-1) infection in mucositis during head and neck cancer radiotherapy.Patients and methods Sixty patients with malignant head and neck tumor, eligible to receive radiotherapy, who were referred to the Dental Oncology Unit, entered the study. Sixteen patients (26.6%) received concomitant chemotherapy. Mucositis was recorded weekly. Smears taken from the ulcers of mucositis grade 2, or 3, or 4 were stained with Papanicolaou and alkaline phosphatase/antialkaline phosphatase immunocytochemical method to identify HSV-1.Main results Forty-eight of all 60 patients developed ulcerative mucositis. Smear was available from 29 of 48 patients with ulcerations. HSV-1 infection was identified in 14 of 29 smears available (48.2%). Mucositis healed or was reduced after 1 week of antiviral treatment in 11 of those 14 HSV-1-positive patients; 3 patients responded to 1 g/day of valacyclovir, 7–2 g/day, and 1 patient responded to i.v. acyclovir. Ulcerations recurred after quitting antivirals. Three patients did not respond to 1 g/day of valacyclovir. No HSV-1-negative patient responded to acyclovir (P=0.000).Conclusion HSV-1 was isolated from 14 of 29 available smears taken from 48 patients with ulcerative mucositis. The incidence of HSV-1 infection during radiotherapy was estimated as being 14 of all 48 patients at risk (29.1%). Healing or reduction in the grade of mucositis after antivirals in HSV-1 positive patients, combined with the negative response to antivirals in HSV-1 negative patients, denoted that HSV-1 infection was a component of ulcerative radiation mucositis in those HSV-1-positive patients. 相似文献
955.
Natalia Asimakopoulou John Souglakos Nikolaos Kentepozidis Athanasios Karampeazis Athanasios Kotsakis Nikolaos Ziras Paris Makrantonakis Efthimios Prinarakis Lambros Vamvakas Vassilis Georgoulias 《Journal of Geriatric Oncology》2019,10(1):143-148
Background
Although colorectal cancer (CRC) is a disease of the older patients, older patients are under-represented from randomized trials. Herein we conducted a retrospective analysis for the effect of panitumumab in the management of older patients (≥65?years) patients with metastatic CRC (mCRC) in the Hellenic Oncology Research Group's (HORG) database.Methods
Τhe efficacy of panitumumab-based chemotherapy as front-line treatment in older patients with mCRC was assessed.Results
In total, 110 older patients with KRAS exon 2 wild type tumors were treated with chemotherapy plus panitumumab. The median age was 74?years; 69.9% of the patients were male, with left-sided primary tumors (78.2%), ECOG Performance Status 0–1 (95.4%) and median number of metastatic sites 2. Sixty-two (Overall Response Rate-ORR: 56.4%; 95% CI: 48.8%–68.1%) achieved an objective response, while 21 (19.1%) had stable disease. Median Progression free survival (PFS) was 9.4?months (95% CI: 7.8–11.0?months) and median Overall survival (OS) 23.0?months (95% CI: 20.6–25.3?months). Additionally, a statistically significant difference in ORR (62.7% vs. 33.3%; p?=?.014), median PFS (12.9 vs. 5.7?months; p?=?.001) and median OS (31.6 vs. 16.7?months; p?<?.001) was observed in patients with left-sided compared to right-sided primary tumor. There was no treatment-related death. Grade 3–4 toxicities were neutropenia (8.9%) and diarrhea (14.5%) whereas skin rash grade 2 or 3 was recorded in 41.1% and 10.7%, respectively.Conclusions
The results of this retrospective study provide the evidence that combination chemotherapy plus panitumumab is active and well tolerated in older patients with mCRC. 相似文献956.
Vassilis Milionis Dimitrios Goutas Dimitrios Vlachodimitropoulos Nikolaos Katsoulas Iason D. Kyriazis Evangelos N. Liatsikos Nikolaos Marinakis TraegerSynodinos Joanne Andreas C. Lazaris Nikolaos Goutas 《Clinical Case Reports》2021,9(10)
The highly syndromic nature of succinate dehydrogenase‐deficient RCCs constitutes their active surveillance and molecular profiling the alpha and omega. 相似文献
957.
Nikos V. Margaritelis George G. Nastos Olga Vasileiadou Panagiotis N. Chatzinikolaou Anastasios A. Theodorou Vassilis Paschalis Ioannis S. Vrabas Antonios Kyparos Ioannis G. Fatouros Michalis G. Nikolaidis 《Acta physiologica (Oxford, England)》2023,238(4):e14017