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51.
Svetlana Bozhkova Rashid Tikhilov Dmitry Labutin Alexey Denisov Igor Shubnyakov Vadim Razorenov Vasilii Artyukh Anna Rukina 《Journal of orthopaedics and traumatology》2016,17(4):369-376
Background
The unsuccessful treatment of prosthetic joint infection (PJI) with two-stage revision leads to infection recurrence. The objectives of the study were to assess the clinical and demographic characteristics of patients with polymicrobial PJI, and to evaluate the role of the microbial profile involved in PJI in the risk of infection recurrence after the first step of two-stage revision surgery.Materials and methods
A retrospective analysis of 189 cases of culture-positive PJI following total hip replacement over a 5-year period was performed. The demographic characteristics of patients, clinical symptoms, microbiology cultures of intraoperative biopsies, laboratory values of C-reactive protein (CRP), white blood cell count and erythrocyte sedimentation rate were analyzed. Patients were divided into two groups—135 with monomicrobial and 54 with polymicrobial infection.Results
Of all patients, 68.9 % in the monomicrobial and 83.3 % in the polymicrobial group had a body mass index >25 kg/m2 (p = 0.05). The median CRP values were 5.7 mg/L (IQR 4.0–10.0 mg/L) in the monomicrobial compared to 8.8 mg/L (IQR 5.0–27 mg/L) in the polymicrobial group (p = 0.01). The percentage of successful outcomes was 27.8 % in patients with microbial associations (p < 0.0001). Gram-negative pathogens caused polymicrobial PJI in 61.5 % of cases with infection recurrence (OR 4.4; 95 % CI 1.18–16.37; p = 0.03).Conclusions
Overweight and obese patients or those with elevated CRP had a greater risk of polymicrobial PJI. They were predisposed to recurrence of infection after the first step of two-stage revision. An unsuccessful outcome was more likely in cases with polymicrobial infection compared to those with monomicrobial infection. In addition, the presence of multidrug-resistant strains of Gram-negative bacteria substantially increased the risk of PJI treatment being unsuccessful.Level of evidence
Level III, therapeutic study.52.
Posner MR Hershock DM Blajman CR Mickiewicz E Winquist E Gorbounova V Tjulandin S Shin DM Cullen K Ervin TJ Murphy BA Raez LE Cohen RB Spaulding M Tishler RB Roth B Viroglio Rdel C Venkatesan V Romanov I Agarwala S Harter KW Dugan M Cmelak A Markoe AM Read PW Steinbrenner L Colevas AD Norris CM Haddad RI;TAX Study Group 《The New England journal of medicine》2007,357(17):1705-1715
53.
Kristina N. Ekdahl Padideh Davoodpour Barbro Ekstrand-Hammarström Karin Fromell Osama A. Hamad Jaan Hong Anders Bucht Camilla Mohlin Gulaim A. Seisenbaeva Vadim G. Kessler Bo Nilsson 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(3):735-744
Iron-oxide nanoparticles (NPs) generated by environmental events are likely to represent health problems. α-Fe2O3 NPs were synthesized, characterized and tested in a model for toxicity utilizing human whole blood without added anticoagulant. MALDI-TOF of the corona was performed and activation markers for plasma cascade systems (complement, contact and coagulation systems), platelet consumption and release of growth factors, MPO, and chemokine/cytokines from blood cells were analyzed. The coronas formed on the pristine α-Fe2O3 NPs contained contact system proteins and they induced massive activation of the contact (kinin/kallikrein) system, as well as thrombin generation, platelet activation, and release of two pro-angiogeneic growth factors: platelet-derived growth factor and vascular endothelial growth factor, whereas complement activation was unaffected. The α-Fe2O3 NPs exhibited a noticeable toxicity, with kinin/kallikrein activation, which may be associated with hypotension and long-term angiogenesis in vivo, with implications for cancer, arteriosclerosis and pulmonary disease. 相似文献
54.
Valerii E. Orel Marina Tselepi Thanos Mitrelias Alexander Rykhalskyi Andriy Romanov Valerii B. Orel Anatoliy Shevchenko Anatoliy Burlaka Sergey Lukin Crispin H.W. Barnes 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(4):1249-1256
Modulation of reactive oxygen and nitrogen species in a tumor could be exploited for nanotherapeutic benefits. We investigate the antitumor effect in Walker-256 carcinosarcoma of magnetic nanodots composed of doxorubicin-loaded Fe3O4 nanoparticles combined with electromagnetic fields. Treatment using the magnetic nanodot with the largest hysteresis loop area (3402 erg/g) had the greatest antitumor effect with the minimum growth factor 0.49 ± 0.02 day–1 (compared to 0.58 ± 0.02 day–1 for conventional doxorubicin). Electron spin resonance spectra of Walker-256 carcinosarcoma treated with the nanodots, indicate an increase of 2.7 times of free iron (that promotes the formation of highly reactive oxygen species), using the nanodot with the largest hysteresis loop area, compared to conventional doxorubicin treatment as well as increases in ubisemiquinone, lactoferrin, NO-FeS-proteins. Hence, we provide evidence that the designed magnetic nanodots can modulate the tumor redox state. We discuss the implications of these results for cancer nanotherapy. 相似文献
55.
This report describes lingual cortical plate loss of the two lower central incisors with second degree mobility in an 18.5-year-old patient. Seven millimeters of clinical attachment losses were detected. For the last 4.5 years, the patient has worn a tongue ornament. The spheres were pressed directly against the periodontal lesion. The metal bar was bent as empirical evidence of the excessive force. Dental practitioners should educate their patients about the risk of oral piercing. 相似文献
56.
Lopez-Ramirez Felipe Gushchin Vadim Sittig Michelle King Mary Caitlin Baron Ekaterina Nikiforchin Andrei Nieroda Carol Sardi Armando 《Annals of surgical oncology》2022,29(6):3404-3404
Annals of Surgical Oncology - 相似文献
57.
Nikiforchin Andrei Sittig Michelle Gushchin Vadim Sardi Armando 《Annals of surgical oncology》2022,29(2):883-884
Annals of Surgical Oncology - 相似文献
58.
Dongsheng Jiang Juliane C. de Vries Jana Muschhammer Susanne Schatz Haifeng Ye Tabea Hein Miray Fidan Vasily S. Romanov Yuval Rinkevich Karin Scharffetter‐Kochanek 《Wound repair and regeneration》2020,28(1):49-60
Nonhealing chronic wounds in the constantly growing elderly population represent a major public health problem with high socioeconomic burden. Yet, the underlying mechanism of age‐related impairment of wound healing remains elusive. Here, we show that the number of dermal cells expressing cyclin‐dependent kinase inhibitor p21 was elevated upon skin injury, particularly in aged population, in both man and mouse. The nuclear expression of p21 in activated wound fibroblasts delayed the onset of the proliferation phase of wound healing in a p53‐independent manner. Further, the local and transient inhibition of p21 expression by in vivo delivered p21‐targeting siRNA ameliorated the delayed wound healing in aged mice. Our results suggest that the increased number of p21+ wound fibroblasts enforces the age‐related compromised healing, and targeting p21 creates potential clinical avenues to promote wound healing in aged population. 相似文献
59.
Vadim Goz Jeffrey H. Weinreb Frank Schwab Virginie Lafage Thomas J. Errico 《The spine journal》2014,14(9):2019-2027
Background contextLumbar interbody fusion (LIF) techniques have been used for years to treat a number of pathologies of the lower back. These procedures may use an anterior, posterior, or combined surgical approach. Each approach is associated with a unique set of complications, but the exact prevalence of complications associated with each approach remains unclear.PurposeTo investigate the rates of perioperative complications of anterior lumbar interbody fusion (ALIF), posterior/transforaminal lumbar interbody fusion (P/TLIF), and LIF with a combined anterior-posterior interbody fusion (APF).Study design/settingRetrospective review of national data from a large administrative database.Patient samplePatients undergoing ALIF, P/TLIF, or APF.Outcome measuresPerioperative complications, length of stay (LOS), total costs, and mortality.MethodsThe Nationwide Inpatient Sample database was queried for patients undergoing ALIF, P/TLIF, or APF between 2001 and 2010 as identified via International Classification of Diseases, ninth revision codes. Univariate analyses were carried out comparing the three cohorts in terms of the outcomes of interest. Multivariate analysis for primary outcomes was carried out adjusting for overall comorbidity burden, race, gender, age, and length of fusion. National estimates of annual total number of procedures were calculated based on the provided discharge weights. Geographic distribution of the three cohorts was also investigated.ResultsAn estimated total of 923,038 LIFs were performed between 2001 and 2010 in the United States. Posterior/transforaminal lumbar interbody fusions accounted for 79% to 86% of total LIFs between 2001 and 2010, ALIFs for 10% to 15%, and APF decreased from 10% in 2002 to less than 1% in 2010. On average, P/TLIF patients were oldest (54.55 years), followed by combined approach (47.23 years) and ALIF (46.94 years) patients (p<.0001). Anterior lumbar interbody fusion, P/TLIF, and combined surgical costs were $75,872, $65,894, and $92,249, respectively (p<.0001). Patients in the P/TLIF cohort had the greatest number of comorbidities, having the highest prevalence for 10 of 17 comorbidities investigated. Anterior-posterior interbody fusion group was associated with the greatest number of complications, having the highest incidence of 12 of the 16 complications investigated.ConclusionsThese data help to define the perioperative risks for several LIF approaches. Comparison of outcomes showed that a combined approach is more expensive and associated with greater LOS, whereas ALIF is associated with the highest postoperative mortality. These trends should be taken into consideration during surgical planning to improve clinical outcomes. 相似文献
60.
Aaron L. Fidler Roberto M. Vanacore Sergei V. Chetyrkin Vadim K. Pedchenko Gautam Bhave Viravuth P. Yin Cody L. Stothers Kristie Lindsey Rose W. Hayes McDonald Travis A. Clark Dorin-Bogdan Borza Robert E. Steele Michael T. Ivy The Aspirnauts Julie K. Hudson Billy G. Hudson 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(1):331-336