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91.
92.
Influence of metabolic syndrome and race on the relationship between intensive blood pressure control and cardiovascular outcomes in the SPRINT cohort 下载免费PDF全文
93.
Ali Manouchehrinia Radu Tanasescu Huner Kareem Oltita P. Jerca Fouzia Jabeen Rachelle Shafei Judith Breuer Keith Neal William Irving Cris S. Constantinescu 《Journal of neurovirology》2017,23(6):839-844
Varicella zoster virus (VZV) infection has been implicated in multiple sclerosis (MS), but direct causal involvement has been disputed. Nevertheless, knowledge of VZV exposure is important, given the risk of serious complications of first exposure while undergoing immunosuppressive treatment, in particular with fingolimod. We distributed questionnaires to MS clinic patients, requesting information about history of chickenpox, sibling/household/occupational exposure, history of zoster (shingles), and disease-modifying treatment. A random, proportionally representative sample of 51 patients that included patients with positive, negative, and unknown chickenpox history were selected for determination of VZV IgG by ELISA. Of 1206 distributed questionnaires, 605 were returned (50% response rate). Of these, 86% reported history of chickenpox, 5.6% gave negative history, and 8.5% did not know. Of 594 who answered the zoster question, 78% gave a negative response, 4% did not know, and 104 (17%) answered yes. Of these, 83 reported 1 episode; 12 had 2; 5 had 3; and 1 each reported 5, 6, and 15 episodes. Of 51 patients tested for VZV IgG (44 “yes,” 4 “no,” and 3 “I don’t know” answers to the question of whether they had chickenpox), 48 were seropositive; the 3 seronegative all had reported having had chickenpox. The high rate of MS patients reporting prior chickenpox infection is comparable with previous reports. A substantial proportion of MS patients, estimated to be higher than an age-matched general population, report single or multiple episodes of zoster. These data are useful for consideration of immunosuppressive treatments and/or VZV and zoster vaccination. 相似文献
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95.
The drug efflux pump P-glycoprotein (P-gp) has been shown to promote multidrug resistance (MDR) in tumors as well as to influence ADME properties of drug candidates. Here we synthesized and tested a series of benzophenone derivatives structurally analogous to propafenone-type inhibitors of P-gp. Some of the compounds showed ligand efficiency and lipophilic efficiency (LipE) values in the range of compounds which entered clinical trials as MDR modulators. Interestingly, although lipophilicity plays a dominant role for P-gp inhibitors, all compounds investigated showed LipE values below the threshold for promising drug candidates. Docking studies of selected analogues into a homology model of P-glycoprotein suggest that benzophenones show an interaction pattern similar to that previously identified for propafenone-type inhibitors. 相似文献
96.
Mughal UR Mehmood R Malik A Ali B Safder M Tareen RB 《Journal of Asian natural products research》2012,14(6):601-606
Spiraeamide, a new sphingolipid, has been isolated from the ethyl acetate-soluble fraction of the methanolic extract of the whole plant of Spiraea brahuica, along with marrubiin, 19-acetylmarrubenol, and 6-acetylmarruenol. Their structures were elucidated by 1H and 13C NMR spectra, and COSY, NOESY, HMQC, HMBC, EI-MS, and FAB-MS experiments. 相似文献
97.
Peyser T Zisser H Khan U Jovanovič L Bevier W Romey M Suri J Strasma P Tiaden S Gamsey S 《Journal of diabetes science and technology》2011,5(3):687-693
Background:
Stress hyperglycemia in the critically ill has been found to be associated with increased morbidity and mortality. Studies have found significant improvements in morbidity and mortality in postsurgical patients whose glucose levels were closely maintained in the euglycemic range. However, subsequent studies, in particular the Normoglycemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE-SUGAR) study, found no improvement in subjects with tight glycemic control. In addition to differences in protocol design, patients in the tight glycemic control arm of the NICE-SUGAR study experienced high rates of hypoglycemia compared with other studies. One interpretation of the NICE-SUGAR study results is that it is difficult to achieve normal glycemia in critically ill patients with existing glucose monitoring technology. The purpose of the study reported here was to evaluate the safety and performance of a continuous intravascular glucose sensor that could be used in the future in critically ill patients.Methods:
A first-generation prototype of an intravascular continuous glucose sensor was evaluated in 29 volunteer subjects with type 1 diabetes mellitus. The sensor operates on the principle of quenched fluorescence. The fluorescent emission from the sensor chemistry is nonlinear, resulting in improved accuracy in the hypoglycemic range. The duration of each study was 8 hours. Sensor output was compared with temporally correlated reference measurements made from venous samples on a laboratory glucose analyzer.Results:
Data were obtained from 18 of the 29 subjects in the study. Data were analyzed retrospectively using a factory calibration plus a one-point in vivo calibration. The mean absolute relative difference was 7.97%, and 95.1% of all the points were in zone A of the Clarke error grid.Conclusions:
This pilot study was the first use in human subjects of a prototype of the GluCath Intravascular Continuous Glucose Monitoring System (GluCath System). The GluCath System is based on a novel fluorescent sensor chemistry. The study found the GluCath System had a high level of accuracy as compared with a laboratory reference analyzer. 相似文献98.
99.
Pattern recognition receptors (PRRs) are known for many years for their role in the recognition of microbial products and
the subsequent activation of the immune system. The 2011 Nobel Prize for medicine indeed rewarded J. Hoffmann/B. Beutler and
R. Steinman for their revolutionary findings concerning the activation of the immune system, thus stressing the significance
of understanding the mechanisms of activation of the innate immunity. Such immunostimulatory activities are of major interest
in the context of cancer to induce long-term antitumoral responses. Ligands for the toll-like receptors (TLRs), a well-known
family of PRR, have been shown to have antitumoral activities in several cancers. Those ligands are now undergoing extensive
clinical investigations both as immunostimulant molecules and as adjuvant along with vaccines. However, when considering the
use of these ligands in tumor therapy, one shall consider the potential effect on the tumor cells themselves as well as on
the entire organism. Recent data indeed demonstrate that TLR activation in tumor cells could trigger both pro- or antitumoral
effect depending on the context. This review discusses this balance between the intrinsic activation of PRR in tumor cells
and the extrinsic microenvironment activation in term of overall effect of PRR ligands on tumor development. We review recent
advances in the field and underline appealing prospects for clinical development of PRR agonists in the light of our current
knowledge on their expression and activation. 相似文献
100.
Shabeen N. Masood Yasir Masood Uzma Naim Muhammad F. Masood 《International journal of gynaecology and obstetrics》2014