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排序方式: 共有449条查询结果,搜索用时 15 毫秒
81.
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We report a new bleeding disease--storage pool deficiency (SPD) of platelets--in pigs from the Mayo swine colony of homozygous von Willebrand's disease (vWD) and of heterozygous carriers of vWD. Levels of factor VIII, von Willebrand factor antigen (vWF:Ag), and ristocetin cofactor (RCof) were similar in the vWD carriers and SPD pigs. The latter pigs, however, had bleeding times of 15 minutes or more and were severe bleeders, in contrast to clinically normal vWD carriers. Platelet aggregation in response to collagen was reduced in most SPD pigs. Total platelet content of ADP, ATP, and serotonin was less than that of normal pigs. While the initial uptake of 14C-labeled serotonin into platelets was similar in SPD and normal pigs, retention of serotonin was reduced in platelets of SPD pigs. Transmission electron microscopy showed a large decrease of dense bodies in the platelets of SPD pigs. These findings support a diagnosis of SPD. Genetic analyses suggest an autosomal recessive mode of inheritance. A breeding program is under way to produce pigs affected only at the SPD gene, thus allowing further characterization of SPD and SPD-carrier pigs. 相似文献
84.
Sue Kirk MSc BNurs RN RM RHV DN Cert Jackie Bailey BSc PhD Yvonne Burkey BA 《Health & social care in the community》1997,5(6):398-407
Recent health service policy in the United Kingdom has emphasized the need to involve local people in health service planning. This paper will describe how local communities were involved in the development of Primary Care Resource Centres. These centres are designed to provide a base for the delivery of a range of health, social welfare and information services within a community setting. Four centres in the process of being developed in one region were selected for in-depth study. The main method of data collection consisted of semi-structured interviews with key “stakeholders”, namely purchasers and providers of primary health care, social care providers, hospital outreach staff and local community and voluntary group workers (Weiss 1983). This paper examines how the health service organizations developing the centres involved local communities in planning them and the obstacles and difficulties encountered. The paper suggests lessons that can be learned for future community involvement in the planning of local health services. 相似文献
85.
Edward White PhD MSc MSc PGCEA RMN DipCPN RNT Tony Butterworth CBE FRCN PhD MSc SRN DN RMN RNT Veronica Bishop PhD MPhil SRN Jerome Carson BA MSc C. Psychol Julie Jeacock BSc MSc & April Clements BA 《Journal of advanced nursing》1998,28(1):185-192
An exploratory study, funded by the Department of Health, London and the Scottish Home and Health Department, Edinburgh, was conducted over an 18-month period to provide an informed view on possible assessment tools that could be used to assess the impact of clinical supervision (CS) in nursing and to report on the CS activities in 23 selected sites in England and Scotland. The study not only examined the utility of several standardized research instruments, to be reported separately, but also explored the experience of a small sub-sample of nurses ( n =34) engaged in CS, as supervisors and supervisees. Interviews were undertaken to help better understand some of the issues involved around the domains of structure, process and outcome. Respondents reported an enthusiasm for the opportunity to talk meaningfully to a trusted colleague about their personal circumstances at work. Such opportunities were particularly welcomed by nurses who wished to reflect upon their own practice with patients, especially when dealing with their clinical conditions which were upsetting, or otherwise challenging, and sometimes harrowing. Substantive and methodological areas of interest for future research are suggested. 相似文献
86.
87.
Walter JB; Brander C; Mammen M; Garboczi DN; Kalams SA; Whitesides GM; Walker BD; Eisen HN 《International immunology》1997,9(3):451-459
HLA-A2 heavy chain and beta 2-microglobulin were expressed in Escherichia
coli, and refolded in the presence of peptides derived from HIV-1 RT and
gag proteins. When recombinant HLA-A2 molecules were attached to cells
lacking HLA-A2, the cells became susceptible to lysis by HLA-A2-restricted
cytotoxic T lymphocyte (CTL) clones specific for peptides derived from RT
and gag proteins. Limiting dilution analyses of peripheral blood
mononuclear cells from HIV-1-infected individuals showed that the
recombinant HLA-A2 peptide complexes covalently immobilized on microspheres
stimulated the development of HLA-A2 peptide-specific CTL. Preformed
HLA-peptide complexes may provide an alternative to immunization procedures
that depend upon intracellular processing of antigen to elicit T cell
responses.
相似文献
88.
Patricia M. Stephenson MSc Dip. Curriculum Dev SRN OND DN CertEd RNT 《Journal of advanced nursing》1985,10(1):3-13
This paper reports on a study concerning the opinions of sisters and nurse teachers regarding the relevance of learning objectives for a specific teaching and learning course for hospital and community sisters. The respondents were 29 sisters who had attended the course, 32 sisters who had not attended the course but who were potential future 'consumers' and 25 nurse teachers. The results showed that a majority of the respondents rated 29 of the objectives as essential and these were suggested as the nucleus of the core curriculum for future courses. Responses to nine of the objectives showed statistically significant differences between the groups. 相似文献
89.
V M Provotorov P E Chesnokov Iu L Pritsepov V I Goptarev V N Sushkov E V Zizemskaia G G Semenkova S I Kuznetsova A E Uvarov 《Meditsinskaia tekhnika》1992,(5):28-31
The paper describes the basic circuit of a tussograph, a device that monitors cough in patients with bronchopulmonary diseases. An NKT-I makes it possible to calculate the number of tussive expulsions, total and peak expulsions, as well as to record their time distribution. The device may be useful in the study into the efficacy of new antitussive drugs and the assessment of cough clearance. It can provide an insight into mucociliary clearance. 相似文献
90.
Sheila Hollingworth MA BEd SRN SCM DN Cert Ed RNT Principal Lecturer in Nursing Studies 《Journal of advanced nursing》1986,11(2):211-216
The focus of this paper is an exploration of the implications for curriculum planning of adopting the nursing process; which, it is suggested, represents the most far-reaching innovation in British nursing of recent years. An examination of the abilities required by nurses in order for them to deliver care in this way shows that to encompass the philosophy of the nursing process, fundamental changes need to be made in the way nurses are prepared in schools of nursing. In particular, to those elements of the curriculum dealing with content and teaching methods. 相似文献