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91.
Tanaseanu C Tudor S Tamsulea I Marta D Manea G Moldoveanu E 《European journal of medical research》2007,12(4):145-151
92.
Predicting the survival status of Intensive Care patients at the end of their hospital stay is useful for various clinical and organizational tasks. Current models for predicting mortality use logistic regression models that rely solely on data collected during the first 24 h of patient admission. These models do not exploit information contained in daily organ failure scores which nowadays are being routinely collected in many Intensive Care Units. We propose a novel method for mortality prediction that, in addition to admission-related data, takes advantage of daily data as well. The method is characterized by the data-driven discovery of temporal patterns, called episodes, of the organ failure scores and by embedding them in the familiar logistic regression framework for prediction. Our method results in a set of D logistic regression models, one for each of the first D days of Intensive Care Unit stay. A model for day d D is trained on the patient subpopulation that stayed at least d days in the Intensive Care Unit and predicts the probability of death at the end of hospital stay for such patients. We implemented our method, with a specific form of episodes, called aligned episodes, on a large dataset of Intensive Care Unit patients for the first 5 days of stay (D = 5) in the unit. We compared our models with ones that were developed on the same patient subpopulations but which did not use the episodes. The new models show improved performance on each of the five days. They also provide insight in the effect of the various selected episodes on mortality. 相似文献
93.
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content 总被引:2,自引:0,他引:2
De Vos KJ Chapman AL Tennant ME Manser C Tudor EL Lau KF Brownlees J Ackerley S Shaw PJ McLoughlin DM Shaw CE Leigh PN Miller CC Grierson AJ 《Human molecular genetics》2007,16(22):2720-2728
Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by death of motoneurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial ALS but the mechanisms whereby they induce disease are not fully understood. Here, we use time-lapse microscopy to monitor for the first time the effect of mutant SOD1 on fast axonal transport (FAT) of bona fide cargoes in living neurons. We analyzed FAT of mitochondria that are a known target for damage by mutant SOD1 and also of membrane-bound organelles (MBOs) using EGFP-tagged amyloid precursor protein as a marker. We studied FAT in motor neurons derived from SOD1G93A transgenic mice that are a model of ALS and also in cortical neurons transfected with SOD1G93A and three further ALS-associated SOD1 mutants. We find that mutant SOD1 damages transport of both mitochondria and MBOs, and that the precise details of this damage are cargo-specific. Thus, mutant SOD1 reduces transport of MBOs in both anterograde and retrograde directions, whereas mitochondrial transport is selectively reduced in the anterograde direction. Analyses of the characteristics of mitochondrial FAT revealed that reduced anterograde movement involved defects in anterograde motor function. The selective inhibition of anterograde mitochondrial FAT enhanced their net retrograde movement to deplete mitochondria in axons. Mitochondria in mutant SOD1 expressing cells also displayed features of damage. Together, such changes to mitochondrial function and distribution are likely to compromise axonal function. These alterations represent some of the earliest pathological features so far reported in neurons of mutant SOD1 transgenic mice. 相似文献
94.
95.
Betsy Sleath Delesha M. Carpenter Scott A. Davis Claire Hayes Watson Charles Lee Ceila E. Loughlin Nacire Garcia Daniel S. Reuland Gail Tudor 《Patient education and counseling》2018,101(6):1051-1057
Objective
We conducted a pragmatic randomized controlled trial to test the effectiveness of an asthma question prompt list with video intervention to increase youth question-asking and provider education during visits.Methods
English or Spanish-speaking youth ages 11–17 with persistent asthma and their parents were enrolled from four rural and suburban pediatric clinics. Youth were randomized to the intervention or usual care groups. Intervention group adolescents watched the video on an iPad and then completed an asthma question prompt list before their visits. Generalized estimating equations were used to analyze the data.Results
Forty providers and 359 patients participated. Intervention group youth were significantly more likely to ask one or more questions about medications, triggers, and environmental control than usual care youth. Providers were significantly more likely to educate intervention group youth about rescue medications, triggers, and environmental control. Intervention group caregivers were not significantly more likely to ask questions.Conclusion
The intervention increased youth question-asking and provider education about medications, triggers, and environmental control. The intervention did not impact caregiver question-asking.Practice implications
Providers/practices should consider having youth complete question prompt lists and watch the video with their parents before visits to increase youth question-asking during visits. 相似文献96.
R. G. Tudor F.R.C.S. I. Haynes F.R.C.S. Denise J. Youngs D. W. Burdon F.R.C.Path. Professor M. R. B. Keighley M.S. F.R.C.S. 《Diseases of the colon and rectum》1988,31(1):28-32
In a prospective, randomized control trial, 152 consecutive patients requiring emergency or complicated colorectal surgery were allocated either to two doses of cefotetan or to five-day cover with gentamicin, and a single dose of metronidazole. Twenty-one patients received 6 gm of cefotetan before prolongation of prothrombin time dictated a change in the dose regimen such that all remaining patients (N = 55) received only 4 gm of cefotetan. The groups were well matched for diagnosis and surgical procedure. Rates of postoperative infection did not differ significantly between the groups, with wound infection rates occurring in 17 of 75 patients receiving gentamicin and metronidazole (22.7 percent) compared with ten of 75 receiving cefotetan (13 percent). Although wound infection rates were lower in the cefotetan group, the incidence of intra-abdominal abscess was similar in both groups. Eight patients receiving cefotetan developed intra-abdominal abscesses (11 percent), compared with seven receiving gentamicin and metronidazole (9 percent). Prolongation of prothrombin time in excess of 13 seconds occurred in six patients receiving cefotetan compared with no patients receiving gentamicin and metronidazole. None of these patients developed clinical bleeding, however. 相似文献
97.
Toma TP Hopkinson NS Polkey MI Geddes DM 《Seminars in respiratory and critical care medicine》2004,25(4):399-404
Recently, several techniques and devices have been suggested for achieving endobronchial volume reduction in patients with emphysema. The proposed devices include bronchial blockers, bronchial valves, glues, biomodulators, and stents for bronchial fenestration; all could be positioned only with flexible bronchoscopy. The current available evidence on safety and efficacy for these methods is based on animal studies and patient case series at best; therefore, all the results should be seen with caution. However, the preliminary work reviewed here suggests that most of the proposed techniques can work, and seem to be safer than surgical volume reduction. We do not yet have a proven, widely applicable endobronchial palliative treatment for severe emphysema, but we have a rapidly growing area of new research in interventional pneumology with preliminary results that challenge traditional medical thinking. 相似文献
98.
99.
Iatrogenic Pseudoaneurysm of the Middle Meningeal Artery after External Ventricular Drain Placement 下载免费PDF全文
Ramesh Grandhi MD Nathan T. Zwagerman MD Philip Lee MD PhD Tudor Jovin MD David O. Okonkwo MD PhD 《Journal of neuroimaging》2015,25(1):140-141
External ventricular drain (EVD) placement is often a routine but lifesaving neurosurgical procedure performed throughout the world. Misadventures involving the procedure are well documented throughout the literature. However, we present a unique case of middle meningeal artery pseudoaneurysm formation after EVD placement not before described and provide a review of the literature. 相似文献