全文获取类型
收费全文 | 3683篇 |
免费 | 206篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 74篇 |
妇产科学 | 34篇 |
基础医学 | 515篇 |
口腔科学 | 97篇 |
临床医学 | 213篇 |
内科学 | 995篇 |
皮肤病学 | 52篇 |
神经病学 | 322篇 |
特种医学 | 169篇 |
外科学 | 609篇 |
综合类 | 14篇 |
预防医学 | 67篇 |
眼科学 | 25篇 |
药学 | 245篇 |
中国医学 | 4篇 |
肿瘤学 | 465篇 |
出版年
2023年 | 25篇 |
2022年 | 36篇 |
2021年 | 79篇 |
2020年 | 38篇 |
2019年 | 51篇 |
2018年 | 75篇 |
2017年 | 54篇 |
2016年 | 65篇 |
2015年 | 66篇 |
2014年 | 103篇 |
2013年 | 113篇 |
2012年 | 180篇 |
2011年 | 226篇 |
2010年 | 123篇 |
2009年 | 85篇 |
2008年 | 159篇 |
2007年 | 185篇 |
2006年 | 220篇 |
2005年 | 172篇 |
2004年 | 221篇 |
2003年 | 164篇 |
2002年 | 201篇 |
2001年 | 70篇 |
2000年 | 105篇 |
1999年 | 140篇 |
1998年 | 58篇 |
1997年 | 52篇 |
1996年 | 43篇 |
1995年 | 43篇 |
1994年 | 53篇 |
1993年 | 50篇 |
1992年 | 73篇 |
1991年 | 69篇 |
1990年 | 66篇 |
1989年 | 80篇 |
1988年 | 62篇 |
1987年 | 66篇 |
1986年 | 52篇 |
1985年 | 43篇 |
1984年 | 25篇 |
1983年 | 23篇 |
1982年 | 15篇 |
1981年 | 9篇 |
1980年 | 8篇 |
1979年 | 9篇 |
1977年 | 9篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1968年 | 6篇 |
1966年 | 4篇 |
排序方式: 共有3913条查询结果,搜索用时 15 毫秒
991.
Ryosuke Shiraishi Takehiro Fujise Tsukasa Kuroki Takashi Kakimoto Lujie Miao Yasuhisa Sakata Seiji Tsunada Takahiro Noda Ryuichi Iwakiri Kazuma Fujimoto 《Journal of gastroenterology》2009,44(10):1026-1035
Purpose
We have shown previously that long-term feeding of beef tallow increases colorectal cancer in rats. This study investigated the effects of enzymic antioxidant, reduced glutathione (GSH), on colon carcinogenesis in rats fed with beef tallow. 相似文献992.
Tochigi M Suga M Ohashi J Otowa T Yamasue H Kasai K Kato T Okazaki Y Kato N Sasaki T 《Schizophrenia Research》2006,88(1-3):260-264
Several lines of evidence have suggested that the metabotropic glutamate receptor 3 (GRM3) gene is a candidate susceptibility gene for schizophrenia. To our knowledge, six studies have investigated the genetic association between GRM3 and schizophrenia, although the results have been quite controversial. In the present study, we investigated the association between the GRM3 gene and schizophrenia in 402 Japanese people by analyzing 10 single nucleotide polymorphisms (SNPs), including all SNPs that showed significant results in previous studies. We observed no significant difference in allelic frequencies or genotypic distributions of the 10 SNPs between the controls and patients. A permutation test showed no significant global differences in estimated haplotype frequencies between the controls and patients. Thus, the present study provides no positive evidence of an association between the GRM3 gene and schizophrenia in the Japanese population. 相似文献
993.
Sound lateralization tests were performed to compare the magnet coil bone-conduction headphone with the giant magnetostrictive bone-conduction headphone using 18 healthy participants. Although, no significant difference between these bone-conduction headphones was obtained for the interaural time difference and interaural intensity difference, a significant difference was obtained for the time-intensity trade. This revealed that the difference between the headphones is apparent in the integration of the heterogeneous sensations of the time and intensity difference at the cognitive level, but no difference is apparent between the homogeneous sensations of the discrimination of interaural time difference or interaural intensity difference at the sensory level. It was concluded that the difference at the cognitive level indicates the better performance of the giant magnetostrictive headphone. 相似文献
994.
Sho Kobayashi Yukihiro Matsuyama Kenichi Sinomiya Shigenori Kawabata Muneharu Ando Tsukasa Kanchiku Takanori Sait Masahito Takahashi Zenya Ito Akio Muramoto Yasushi Fujiwara Kazunobu Kida Kei Yamada Kanichiro Wada Naoya Yamamoto Kazuhiko Satomi Toshikazu Tani 《Clinical neurophysiology》2013,124(8):e21-e22
995.
Repeated water avoidance stress induces visceral hypersensitivity: Role of interleukin‐1, interleukin‐6, and peripheral corticotropin‐releasing factor
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
996.
Keiji Inoue Tsutomu Tomioka Yoshitsugu Tajima Tomohiro Fukahori Toshifumi Eto Tsukasa Tsunoda Takashi Kanematsu 《Journal of surgical oncology》1994,56(4):269-276
A carcinoma of the gallbladder was transplantable in Syrian golden hamsters. The tumor was induced by subcutaneous injection of N-nitrosobis (2-oxopropyl) amine (BOP) following dissection of the common duct and preparation of a cholecysto-duodenostomy. The histology revealed a poorly differentiated adenocarcinoma. The tumor was inoculated into the cavity of the gallbladder and subcutaneous tissue of the hamster and was transplantable (uptake rate was 100%). This tumor expressed blood grouprelated antigens, including A, H, and P-glycoproteins. To our knowledge, this is the first report of carcinoma of the gallbladder transplantable in a laboratory animal. © 1994 Wiley-Liss, Inc. 相似文献
997.
Tetsushi Kinugasa Motomu Kuroki Takahiko Yamanaka Yoshino Matsuo Shinzo Oikawa Hiroshi Nakazato Yuji Matsuota 《International journal of cancer. Journal international du cancer》1994,58(1):102-107
Recent studies have shown that, even with a minimal content of carcinoembryonic antigen (CEA), normal human colonic epithelial cells express substantial amounts of CEA mRNA and colonic mucosal fragments cultured in vitro produce CEA quite actively, indicating that CEA should no longer be considered to be of an oncofetal nature. To understand the basis of the usefulness of CEA as a tumor marker, we analyzed the release of CEA, a glycosyl-phosphatidylinositol (GPI)-anchored protein, from colonic epithelial cells, by culturing isolated colonic crypts in collagen gel. The crypts appeared to preserve their morphological and biochemical integrity in the gel for at least 16 hr, and released CEA spontaneously. Three forms of CEA—spontaneously released CEA, CEA liberated with phosphatidylinositol-specific phospholipase C (PI-PLC) and CEA in cell lysates—were indistinguishable on SDS-PAGE. This is in contrast to recombinant CEA spontaneously released from CHO transfectants, which showed a smaller molecular mass than that of PI-PLC-cleaved recombinant CEA. By phase separation using Triton X-114, CEA in the cell lysates of crypts was separated mostly into the detergent phase, while the spontaneously released and the PI-PLC-cleaved CEA were separated into the aqueous phase. When the cells were metabolically labeled with the precursors of the GPI-anchor, 3H-ethanolamine but not JH-palmitic acid was found in the spontaneously released CEA. These findings suggest that, in contrast to the proteolysis-like release of the recombinant CEA from CHO cells, CEA in normal colonic epithelial cells is released by a non-proteolytic cleavage, which probably occurs through the action of some endogenous phospholipase. © 1994 Wiley-Liss, Inc. 相似文献
998.
Two cases of focal nodular hyperplasia of the liver: Value of scintigraphy with Tc-99m GSA and positron emission tomography with FDG 总被引:1,自引:0,他引:1
Shiomi S Kurooka H Iwata Y Sasaki N Masaki K Jomura H Nishiguchi S Kuroki T Ochi H 《Annals of nuclear medicine》1999,13(6):427-431
Focal nodular hyperplasia (FNH) of the liver is relatively rare, and can be difficult to differentiate from other benign tumors arising in the liver. We describe a 23-year-old woman and a 25-year-old man with FNH. They were hospitalized for further evaluation of a space-occupying lesion in the liver. Scintigraphy with Tc-99m diethylenetriaminepentaacetic acid galactosyl human serum albumin (Tc-99m GSA) revealed increased radioactivity in the tumor in one patient and radioactivity similar to that in the normal part of liver in the other. F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) showed uptake similar to that of the normal liver in both patients. FNH was diagnosed on the basis of angiographic findings and histological findings in liver biopsy specimens. Our results show that scintigraphy with Tc-99m GSA and FDG-PET may provide information helpful in the diagnosis of FNH. 相似文献
999.
Hida J Yasutomi M Maruyama T Yoshifuji T Tokoro T Wakano T Uchida T Ueda K 《Surgery today》1999,29(12):1237-1242
The functional outcome after a low anterior resection for rectal cancer is improved by a colonic J-pouch reconstruction. One
functional problem with J-pouches is difficulty in evacuation, which is more common with large reconstructions. Since rectoceles
are common findings on defecography in patients with evacuation difficulties, we proposed that a rectocele-like prolapse may
be thus found in patients with large J-pouches. Pouchography was used to identifya rectocele-like prolapse (RP) in 26 patients with a 10-cm J-pouch (10-J group) and 27 patients with a 5-cm J-pouch (5-J group).
Pouchography was performed at 3 months, 1 year, and 2 years after surgery. Functional assessments were performed 1 year postoperatively.
Clinical function was evaluated using a questionnaire. The evacuation function was evaluated by the balloon expulsion and
saline evacuation test. No patients had an RP at 3 months or 1 year after surgery. An RP was significantly more common in
the 10-J group than in the 5-J group at 2 years after surgery (P=0.0374). An evacuation difficulty was significantly more common in the 10-J group than in the 5-J group. The evacuation function
in the 10-J group was also significantly inferior to that in the 5-J group. An RP appearing 2 years after surgery is more
common in patients with evacuation difficulties and large colonic J-pouch reconstructions.
This work was supported in part by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture
and Science, and a grant for Cancer Research from the Osaka Cancer Foundation. 相似文献
1000.
Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome 总被引:4,自引:0,他引:4
Miyaki M Iijima T Hosono K Ishii R Yasuno M Mori T Toi M Hishima T Shitara N Tamura K Utsunomiya J Kobayashi N Kuroki T Iwama T 《Cancer research》2000,60(22):6311-6313
Peutz-Jeghers syndrome (PJS) is characterized by multiple gastrointestinal hamartomatous polyps, mucocutaneous melanin deposition, and increased risk of cancer, mainly in the gastrointestinal tract. We examined mutations of the LKB1, beta-catenin, APC, K-ras, and p53 genes in 27 gastrointestinal hamartomatous polyps from 10 patients in nine PJS families. Of these hamartomatous polyps, one intestinal polyp had an adenomatous lesion, and one gastric polyp contained adenomatous and carcinomatous lesions. Germ-line mutations of the LKB1 gene were detected in six PJS families. Somatic mutations of the LKB1 gene were found in 5 polyps, whereas loss of heterozygosity (LOH) at the LKB1 locus at 19p was seen in 14 other polyps. In adenomatous lesions microdissected from hamartomatous polyps, both beta-catenin mutation and 19p LOH were detected. Furthermore, a carcinomatous lesion in a gastric hamartomatous polyp was found to contain a mutation of the p53 gene and LOH at the p53 locus in addition to LOH at the LKB1 locus and a beta-catenin mutation. K-ras mutations were detected in a few polyps, whereas no APC mutation or 5q LOH was detected in hamartomatous polyps. These results suggest that gastrointestinal hamartomatous polyps in PJS patients develop through inactivation of the LKB1 gene by germ-line mutation plus somatic mutation or LOH of the unaffected LKB1 allele, and that additional mutations of the beta-catenin gene and p53 gene convert hamartomatous polyps into adenomatous and carcinomatous lesions. 相似文献