全文获取类型
收费全文 | 400篇 |
免费 | 45篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 15篇 |
妇产科学 | 3篇 |
基础医学 | 31篇 |
口腔科学 | 4篇 |
临床医学 | 50篇 |
内科学 | 79篇 |
皮肤病学 | 5篇 |
神经病学 | 1篇 |
特种医学 | 169篇 |
外科学 | 37篇 |
综合类 | 7篇 |
预防医学 | 16篇 |
眼科学 | 6篇 |
药学 | 22篇 |
肿瘤学 | 11篇 |
出版年
2018年 | 7篇 |
2016年 | 7篇 |
2013年 | 9篇 |
2012年 | 9篇 |
2011年 | 14篇 |
2010年 | 10篇 |
2009年 | 12篇 |
2008年 | 6篇 |
2007年 | 14篇 |
2006年 | 5篇 |
2005年 | 6篇 |
2004年 | 14篇 |
2003年 | 4篇 |
2002年 | 6篇 |
2001年 | 10篇 |
2000年 | 3篇 |
1999年 | 8篇 |
1998年 | 21篇 |
1997年 | 19篇 |
1996年 | 19篇 |
1995年 | 16篇 |
1994年 | 17篇 |
1993年 | 15篇 |
1991年 | 5篇 |
1990年 | 9篇 |
1989年 | 12篇 |
1988年 | 16篇 |
1987年 | 15篇 |
1986年 | 18篇 |
1985年 | 24篇 |
1984年 | 10篇 |
1983年 | 14篇 |
1982年 | 11篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 8篇 |
1975年 | 3篇 |
1974年 | 4篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1970年 | 2篇 |
1969年 | 5篇 |
1968年 | 4篇 |
1967年 | 6篇 |
1966年 | 2篇 |
1965年 | 2篇 |
1964年 | 2篇 |
排序方式: 共有457条查询结果,搜索用时 15 毫秒
451.
Long-term treatment of lupus nephritis with cyclosporin A 总被引:9,自引:0,他引:9
Tam LS; Li EK; Leung CB; Wong KC; Lai FM; Wang A; Szeto CC; Lui SF 《QJM : monthly journal of the Association of Physicians》1998,91(8):573-580
We evaluated the efficacy and safety of long-term treatment with
cyclosporin A (CSA) in type IV lupus nephritis. Seventeen patients with
biopsy-proven WHO type IV lupus nephritis were enrolled in a prospective,
open study. Twelve of the 17 completed 48 months of treatment with CSA and
prednisolone. Three patients required the addition of azathioprine, at 12,
38 and 47 months, respectively, for cutaneous disease flare with refractory
rashes. One patient was lost to follow-up at 40 months. The mean +/- SD
duration of treatment was 43.2 +/- 10.1 months (range 15.7-48 months). A
significant reduction of proteinuria and a significant rise in serum
albumin were noted 1 month after initiation of treatment. Improvement was
maintained throughout the study except for three patients who relapsed with
recurrence of nephrotic syndrome. There were no significant changes in
serum creatinine level or creatinine clearances throughout the study.
Repeat renal biopsy at 12 months following treatment with CSA showed
histological improvement, with WHO type II changes in all 17 patients
accompanying significant reduction in activity indices. Patients with
baseline haemoglobin (Hgb) levels < 12 g/dl showed significant
improvement. Serum C3 and C4 levels were not changed significantly.
Corticosteroid-sparing effects were noted. Side-effects included
hypertension, gum hypertrophy and mild hirsuitism, but were not serious.
Combination therapy using CSA and prednisone is effective and safe for
long-term treatment in lupus patients with WHO type IV nephritis.
相似文献
452.
R Silvis ; WH Steup ; A Brand ; KA Zwinderman ; CB Lamers ; G Griffioen ; HG Gooszen 《Transfusion》1994,34(3):242-247
BACKGROUND: Perioperative blood transfusion (BT) appeared to have adverse effects on survival after surgery for malignant tumors while pretransplantation BT suppressed allograft rejection. Interest grew in the effect of BT on postoperative recurrence of Crohn's disease. STUDY DESIGN AND METHODS: To determine the effect of perioperative BT on the recurrence of Crohn's disease after primary surgery, the medical histories of 148 patients with Crohn's disease, 62 males and 86 females (49 nonparous and 37 parous), were reviewed. Eighty-seven patients received perioperative BT. RESULTS: Overall, perioperative BT showed no effect on recurrence. Patients with Crohn's disease limited to the ileum had a better prognosis with regard to recurrence than did patients with Crohn's disease located in the colon or located in both ileum and colon, but the difference was not significant. Perioperative transfusion seemed to protect against recurrent disease after colon resection, which might be explained by the fact that colon resections, which often necessitate perioperative BT, generally result in a shorter bowel segment at risk for recurrent disease. Overall, parous women showed a worse prognosis than nonparous females and men (p = 0.022). Transfusions had a beneficial effect in parous women (p = 0.068) and, after correction for type of operation, this beneficial effect was significant (p = 0.026). After perioperative BT, parous women had a similar prognosis with respect to recurrent Crohn's disease as nonparous females and men. CONCLUSION: Perioperative BT has a beneficial effect on the postoperative recurrence of Crohn's disease in parous women. 相似文献
453.
Severe deficiency of cystic fibrosis transmembrane conductance regulator messenger RNA carrying nonsense mutations R553X and W1316X in respiratory epithelial cells of patients with cystic fibrosis. 总被引:4,自引:6,他引:4 下载免费PDF全文
454.
455.
Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. 总被引:16,自引:1,他引:16 下载免费PDF全文
456.
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43) 总被引:2,自引:0,他引:2
Eckman CB; Mehta ND; Crook R; Perez-tur J; Prihar G; Pfeiffer E; Graff- Radford N; Hinder P; Yager D; Zenk B; Refolo LM; Prada CM; Younkin SG; Hutton M; Hardy J 《Human molecular genetics》1997,6(12):2087-2089
We report a novel mutation in the amyloid precursor protein gene (APP
I716V) which probably leads to familial early onset Alzheimer's disease
with an onset age in the mid 50s. Cells transfected with cDNAs bearing this
mutation produce more A beta 1-42(43) than those transfected with wild-type
APP and this effect is additive with that of the previously reported APP
V717I mutation thus providing a novel approach for further increasing A
beta 1-42(43) in model systems.
相似文献
457.
Berclaz PY Carey B Fillipi MD Wernke-Dollries K Geraci N Cush S Richardson T Kitzmiller J O'connor M Hermoyian C Korfhagen T Whitsett JA Trapnell BC 《American journal of respiratory cell and molecular biology》2007,36(1):114-121
Alveolar macrophages (AMs) normally respond to lipopolysaccharide (LPS) by activating Toll-like receptor (TLR)-4 signaling, a mechanism critical to lung host defense against gram-negative bacteria such as Pseudomonas aeruginosa. Because granulocyte macrophage colony-stimulating factor (GM-CSF)-deficient (GM(-/-)) mice are hyporesponsive to LPS, we evaluated the role of GM-CSF in TLR-4 signaling in AMs. Pulmonary TNF-alpha levels and neutrophil recruitment 4 h after intratracheal administration of Pseudomonas LPS were reduced in GM(-/-) compared with wild-type (GM(+/+)) mice. Secretion of TNF-alpha by AMs exposed to LPS ex vivo was also reduced in GM(-/-) mice and restored in mice expressing GM-CSF specifically in the lungs (SPC-GM(+/+)/GM(-/-) mice). LPS-dependent NF-kappaB promoter activity, TNF-alpha secretion, and neutrophil chemokine release were reduced in AM cell lines derived from GM(-/-) mice (mAM) compared with GM(+/+) (MH-S). Retroviral expression of PU.1 in mAM cells, which normally lack PU.1, rescued all of these AM defects. To determine whether GM-CSF, via PU.1, regulated expression of TLR-4 pathway components, mRNA and protein levels for key components were evaluated in MH-S cells (GM(+/+), PU.1(Positive)), mAM cells (GM(-/-), PU.1(Negative)), and mAMPU.1+ cells (GM(-/-), PU.1(Positive)). Cluster of differentiation antigen-14, radioprotective 105, IL-1 receptor-associated kinase (IRAK)-M mRNA, and protein were dependent upon GM-CSF and restored by expression of PU.1. In contrast, expression of other TLR-4 pathway components (myeloid differentiation-2, TLR-4, IRAK-1, IRAK-2, Toll/IL-1 receptor domain containing adapter protein/MyD88 adaptor-like, myeloid differentiation primary-response protein 88, IRAK-4, TNF receptor-associated factor-6, NF-kappaB, inhibitor of NF-kappaB kinase) were not GM-CSF or PU.1-dependent. These results show that GM-CSF, via PU.1, enables AM responses to P. aeruginosa LPS by regulating expression of a specific subset of components of the TLR-4 signaling pathway. 相似文献