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91.
Song-Huy Nguyen-Dinh Albert Do Trang Ngoc Doan Pham Doan Y Dao Trinh Nhu Nguy Moon S Chen Jr 《World journal of hepatology》2018,10(1):116-123
AIM To examine the largest tertiary referral center in southern and central Vietnam from 2010 to 2016, evaluating epidemiological trends of hepatocellular carcinoma(HCC) and viral hepatitis B-C in this resource-limited setting.METHODS We extracted data of patients receiving care from Cho Ray Hospital(Ho Chi Minh City), the largest oncology referral center in southern and central Vietnam, from 2010 to 2016. We collected information on patient age, gender, geographic distribution, and disease characteristics including disease stage, tumor biomarker levels [serum alpha-fetoprotein(AFP), AFP-L3 isoform percentage, and prothrombin induced by induced by vitamin K absence-Ⅱ], and serological testing for hepatitis B virus(HBV) and hepatitis C virus(HCV) infections.RESULTS Data from 24091 HCC patients were extracted, with sample demographics comprising mostly male(81.8%) and older age(however with 8.5% younger than 40 years old). This patient sample included a geographic catchment population of 56 million people(60% of the country's total population of 92.7 million), derived from 38 provinces and municipalities in Vietnam. Chronic HBV infection was found in 62.3% of cases, and chronic HCV infection in 26.0%. HBV and HCV co-infection was seen in 2.7%. Cirrhosis was found in an estimated 30% to 40% of cases. Nine percent of patients were not found to have chronic viral hepatitis. Twenty three point two percent of the patients had a normal AFP level. A total of 2199 patients were tested with AFP-L3 and PIVKA Ⅱ over two years, with 57.7% having elevated AFP-L3%, and 88.5% with elevated PIVKA Ⅱ levels. Over this 7-year period, the incidence of HCC increased, with a large proportion of cases(overall 40.8%) presenting initially an advanced stage, not amendable to surgical or locoregional therapy.CONCLUSION HCC contributes significant health care burden in southern and central Vietnam, with increasing case volume over this seven-year period. Viral hepatitis likely explains this high HCC prevalence. 相似文献
92.
Quality of antiepileptic drugs in sub‐Saharan Africa: A study in Gabon,Kenya, and Madagascar
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Jeremy Jost Voa Ratsimbazafy Thu Trang Nguyen Thuy Linh Nguyen Hanh Dufat Annabelle Dugay Alassane Ba Guilhem Sivadier Yattussia Mafilaza Cyril Jousse Mounir Traïkia Martin Leremboure Emilie Auditeau Adeline Raharivelo Edgard Ngoungou Symon M. Kariuki Charles R. Newton Pierre‐Marie Preux 《Epilepsia》2018,59(7):1351-1361
93.
Joshua E. Sealy Guillaume Fournie Pham Hong Trang Nguyen Hoang Dang Jean‐Remy Sadeyen To Long Thanh H. Rogier van Doorn Juliet E. Bryant Munir Iqbal 《Transboundary and Emerging Diseases》2019,66(6):2507-2516
Vietnamese poultry are host to co‐circulating subtypes of avian influenza viruses, including H5N1 and H9N2, which pose a great risk to poultry productivity and to human health. AIVs circulate throughout the poultry trade network in Vietnam, with live bird markets being an integral component to this network. Traders at LBMs exhibit a variety of trading practices, which may influence the transmission of AIVs. We identified trading practices that impacted on AIV prevalence in chickens marketed in northern Vietnamese LBMs. We generated sequencing data for 31 H9N2 and two H5N6 viruses. Viruses isolated in the same LBM or from chickens sourced from the same province were genetically closer than viruses isolated in different LBMs or from chickens sourced in different provinces. The position of a vendor in the trading network impacted on their odds of having AIV‐infected chickens. Being a retailer and purchasing chickens from middlemen was associated with increased odds of infection, whereas odds decreased if vendors purchased chickens directly from large farms. Odds of infection were also higher for vendors having a greater volume of ducks unsold per day. These results indicate how the spread of AIVs is influenced by the structure of the live poultry trading network. 相似文献
94.
Lopez TC Trang DD Farrell NC De Leon MA Villarreal CC Maize DF 《American journal of pharmaceutical education》2011,75(5):89
The Feik School of Pharmacy collaborated with a commercial software development company to create a Web-based e-portfolio system to document student achievement of curricular outcomes and performance in pharmacy practice experiences. The multi-functional system also could be used for experiential site selection and assignment and continuing pharmacy education. The pharmacy school trained students, faculty members, and pharmacist preceptors to use the e-portfolio system. All pharmacy students uploaded the required number of documents and assessments to the program as evidence of achievement of each of the school's curricular outcomes and completion of pharmacy practice experiences. 相似文献
95.
Valproic acid (VPA) has extensive effects on leukemic blasts through its inhibition of histone deacetylases. The main goal of this study was to identify the subgroup of patients who may benefit most from VPA treatment. We examined the significance of t(8;21) chromosomal aberration for VPA treatment response among acute myeloid leukemia (AML) patients by direct comparison of AML1/ETO-negative vs. positive leukemic cell-lines as well as bone marrow blasts from AML patients. In t(8;21) AML, leukemogenesis is supposed to be induced via aberrant recruitment of histone deacetylases. AML cell lines of different genotypes (Kasumi-1, Kasumi-6, MV4;11, K562) and diagnostic bone marrow samples from patients were treated with VPA. VPA induced apoptosis in AML1/ETO-positive and MLL-AF4-positive cells in a dose-dependent manner. Differentiation, as indicated by changes in immunophenotype, was observed only in AML1/ETO-positive cells. VPA increased the expression of AML1 target genes - PU.1, C/EBPa, BPI and IGFBP7 only in AML1/ETO-positive cells. This AML1/ETO-specific effect was confirmed also using patient blasts isolated at the time of diagnosis. AML1/ETO-positive leukemia shows specific mechanism of VPA residing from differentiation followed by apoptosis that is accompanied by an increase in the expression of repressed AML1 target genes. Our data suggest that AML1/ETO-positive patients might derive the greatest benefit from VPA treatment. 相似文献
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98.
Predictive hyperglycemia and hypoglycemia minimization: In‐home double‐blind randomized controlled evaluation in children and young adolescents
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Gregory P Forlenza Dan Raghinaru Faye Cameron B Wayne Bequette H Peter Chase R Paul Wadwa David M Maahs Emily Jost Trang T Ly Darrell M Wilson Lisa Norlander Laya Ekhlaspour Hyojin Min Paula Clinton Nelly Njeru John W Lum Craig Kollman Roy W Beck Bruce A Buckingham for the In‐Home Closed‐Loop Study Group 《Pediatric diabetes》2018,19(3):420-428
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D. Rades M.D. L. Dziggel B. Segedin MD I. Oblak MD V. Nagy MD PhD A. Marita MD S.E. Schild MD N.T. Trang MD M.T. Khoa MD PhD 《Strahlentherapie und Onkologie》2013,189(9):777-781