全文获取类型
收费全文 | 5416篇 |
免费 | 388篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 60篇 |
儿科学 | 214篇 |
妇产科学 | 170篇 |
基础医学 | 673篇 |
口腔科学 | 74篇 |
临床医学 | 822篇 |
内科学 | 953篇 |
皮肤病学 | 136篇 |
神经病学 | 462篇 |
特种医学 | 122篇 |
外科学 | 589篇 |
综合类 | 36篇 |
一般理论 | 5篇 |
预防医学 | 517篇 |
眼科学 | 156篇 |
药学 | 398篇 |
1篇 | |
中国医学 | 23篇 |
肿瘤学 | 402篇 |
出版年
2024年 | 15篇 |
2023年 | 74篇 |
2022年 | 100篇 |
2021年 | 212篇 |
2020年 | 124篇 |
2019年 | 184篇 |
2018年 | 220篇 |
2017年 | 156篇 |
2016年 | 173篇 |
2015年 | 162篇 |
2014年 | 200篇 |
2013年 | 296篇 |
2012年 | 421篇 |
2011年 | 474篇 |
2010年 | 217篇 |
2009年 | 251篇 |
2008年 | 365篇 |
2007年 | 422篇 |
2006年 | 331篇 |
2005年 | 336篇 |
2004年 | 264篇 |
2003年 | 272篇 |
2002年 | 223篇 |
2001年 | 33篇 |
2000年 | 20篇 |
1999年 | 32篇 |
1998年 | 35篇 |
1997年 | 22篇 |
1996年 | 23篇 |
1995年 | 18篇 |
1994年 | 13篇 |
1993年 | 11篇 |
1992年 | 5篇 |
1991年 | 10篇 |
1990年 | 5篇 |
1989年 | 23篇 |
1988年 | 6篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 5篇 |
1984年 | 10篇 |
1983年 | 4篇 |
1982年 | 7篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1968年 | 3篇 |
排序方式: 共有5813条查询结果,搜索用时 15 毫秒
91.
92.
Ateba Ngoa U Schaumburg F Adegnika AA Kösters K Möller T Fernandes JF Alabi A Issifou S Becker K Grobusch MP Kremsner PG Lell B 《Acta tropica》2012,124(1):42-47
Little data is available on the epidemiology of Staphylococcus aureus in Africa. In the present study we aim at characterizing the population structure of S. aureus in healthy subjects from a rural and a semi-urban area in Lambaréné, Gabon as well as in hospital staff and inpatients. In total, 500 subjects were screened for S. aureus colonization of the nares, axillae and inguinal region. Overall, 146 (29%) were positive. We found 46 different spa types. The most frequent spa types were t084 (35%) and the agr II was the most prevalent subtype of the accessory gene regulator (56%, n=82). Five isolates (3%) were methicillin resistant S. aureus (MRSA). Carriage rates of S. aureus in Gabon are comparable to developed countries. MRSA is for the first time described and could pose a significant health threat in this region with limited access to microbiological laboratory facilities and to adequate antimicrobial agents. 相似文献
93.
Boris Ionin Robert J. Hopkins Brett Pleune Gloria S. Sivko Frances M. Reid Kristin H. Clement Thomas L. Rudge Jr. Gregory V. Stark Alison Innes Suha Sari Tina Guina Cris Howard Jeffrey Smith M. Lisa Swoboda Ekaterina Vert-Wong Virginia Johnson Gary S. Nabors Mario H. Skiadopoulos 《Clinical and Vaccine Immunology : CVI》2013,20(7):1016-1026
Antimicrobials administered postexposure can reduce the incidence or progression of anthrax disease, but they do not protect against the disease resulting from the germination of spores that may remain in the body after cessation of the antimicrobial regimen. Such additional protection may be achieved by postexposure vaccination; however, no anthrax vaccine is licensed for postexposure prophylaxis (PEP). In a rabbit PEP study, animals were subjected to lethal challenge with aerosolized Bacillus anthracis spores and then were treated with levofloxacin with or without concomitant intramuscular (i.m.) vaccination with anthrax vaccine adsorbed (AVA) (BioThrax; Emergent BioDefense Operations Lansing LLC, Lansing, MI), administered twice, 1 week apart. A significant increase in survival rates was observed among vaccinated animals compared to those treated with antibiotic alone. In preexposure prophylaxis studies in rabbits and nonhuman primates (NHPs), animals received two i.m. vaccinations 1 month apart and were challenged with aerosolized anthrax spores at day 70. Prechallenge toxin-neutralizing antibody (TNA) titers correlated with animal survival postchallenge and provided the means for deriving an antibody titer associated with a specific probability of survival in animals. In a clinical immunogenicity study, 82% of the subjects met or exceeded the prechallenge TNA value that was associated with a 70% probability of survival in rabbits and 88% probability of survival in NHPs, which was estimated based on the results of animal preexposure prophylaxis studies. The animal data provide initial information on protective antibody levels for anthrax, as well as support previous findings regarding the ability of AVA to provide added protection to B. anthracis-infected animals compared to antimicrobial treatment alone. 相似文献
94.
95.
96.
Cherry JD Tan T Wirsing von K?nig CH Forsyth KD Thisyakorn U Greenberg D Johnson D Marchant C Plotkin S 《Clinical infectious diseases》2012,54(12):1756-1764
Existing clinical case definitions of pertussis are decades old and based largely on clinical presentation in infants and children, yet an increasing burden is borne by adolescents and adults who may manifest distinct signs/symptoms. Therefore, a "one-size-fits-all" clinical case definition is no longer appropriate. Seeking to improve pertussis diagnosis, the Global Pertussis Initiative (GPI) developed an algorithm that delineates the signs/symptoms of pertussis most common to 3 age groups: 0-3 months, 4 months to 9 years, and ≥10 years. These case definitions are based on clinical presentation alone, but do include recommendations on laboratory diagnostics. Until pertussis can be accurately diagnosed, its burden will remain underestimated, making the introduction of epidemiologically appropriate preventive strategies difficult. The proposed definitions are intended to be widely applicable and to encourage the expanded use of laboratory diagnostics. Determination of their utility and their sensitivity and/or specificity versus existing case definitions is required. 相似文献
97.
98.
99.
Frederic Mercier Tina M. Weatherby Daniel K. Hartline 《The Journal of comparative neurology》2013,521(4):760-790
Meninges, the connective tissue of the vertebrate central nervous system (CNS), have not been recognized in invertebrates. We describe the ultrastructure of the adult brain, antennules, and cord in five marine copepods: Calanus finmarchicus, Gaussia princeps, Bestiolina similis, Labidocera madurae, and Euchaeta rimana. In all of these locations we identified cell types with characteristics of the typical cells of vertebrate meninges and of their peripheral nervous system (PNS) connective tissue counterpart: fibroblasts, having flattened twisting processes with labyrinthine cavities communicating with the extracellular space, and macrophages, containing prominent lysosomes, well‐developed endoplasmic reticulum, Golgi apparatus, and indented heterochromatin. The vertebrate distinction between electron‐dense cells in the most external connective tissues (dura mater and epineurium) versus electron‐lucent cells in the more internal connective tissues (pia‐arachnoid and endoneurium‐perineurium) was also found in the copepod CNS and PNS. Similar to the vertebrate organization, electron‐dense cell networks penetrated from the outer layer (subcuticle) to surround inner substructures of the copepod nervous systems, and electron‐lucent networks penetrated deeply from the brain and nerve surfaces to form intertwined associations with neural cells. Moreover, the association of these cells with basement membranes, glycocalyx, and fibrils of collagen in copepods conforms to a meningeal organization. The primary deviation from the vertebrate ultrastructural organization was the often tight investment of axons by the meningeal‐like cells, with an intercalated basement membrane. Together, these data suggest that the tissues investing the copepod nervous system possess an organization that is analogous in many respects to that of vertebrate meninges. J. Comp. Neurol. 521:760–790, 2013. © 2012 Wiley Periodicals, Inc. 相似文献
100.