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81.
Axillary lymph node status remains an important prognostic factor in patients with breast cancer. Axillary ultrasound (AUS) is an important tool in the workup of patients with newly diagnosed breast cancer and also has an emerging role evaluating the axilla after neoadjuvant chemotherapy. This review discusses the value of AUS in the workup and management of patients with newly diagnosed breast cancer and describes its role given the recent changes in axillary management. 相似文献
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Mundhenke C Weigel MT Sturner KH Roesel F Meinhold-Heerlein I Bauerschlag DO Schem C Hilpert F Jonat W Maass N 《Journal of cancer research and clinical oncology》2008,134(12):1397-1405
Purpose Imatinib is a small molecule inhibiting the tyrosine kinases bcr-abl, c-kit, PDGFR-α and PDGFR-β. Investigations were performed
to screen ovarian cancer cell lines and tumor samples for target receptor expression. Effects of Imatinib on cell proliferation
and apoptosis induction were measured with and without additional cytotoxic agents.
Methods Expression patterns of abl, c-kit, PDGFR-α and PDGFR-β (Imatinib targets) were studied in 5 cell lines and 111 tissue arrays
by PCR and immunohistochemistry. Proliferation assays were performed with single agent Imatinib or combined with Paclitaxel
and Carboplatin. Apoptosis was measured by DNA fragmentation.
Results All cell lines expressed abl and PDGFR-β. C-kit was only expressed in 2/5 cell lines and PDGFR-α in 4/5. Imatinib reduced
cell growth and lead to pro-apoptotic changes. Combination of Carboplatin, Paclitaxel and Imatinib showed synergistic activity.
Conclusions Our results suggest that Imatinib may be useful for the specific treatment of ovarian cancer as an add-on to conventional
chemotherapy.
C. Mundhenke and M. T. Weigel contributed equally to this work. 相似文献
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Kristine Yaffe MD Manjula Kurella‐Tamura MD MPH Lynn Ackerson PhD Tina D. Hoang MSPH Amanda H. Anderson PhD Mark Duckworth MPH Alan S. Go MD Marie Krousel‐Wood MD MSPH John W. Kusek PhD James P. Lash MD Akinlolu Ojo MD PhD Nancy Robinson PhD Ashwini R. Sehgal MD James H. Sondheimer MD Susan Steigerwalt MD Raymond R. Townsend MD the CRIC Study Investigators 《Journal of the American Geriatrics Society》2014,62(9):1623-1629
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Tina Rdig Juliane Krmer Christine Müller Annette Wiegand Franziska Haupt Marta Rizk 《Australian endodontic journal : the journal of the Australian Society of Endodontology Inc》2019,45(3):394-399
This study evaluated the effect of three different NiTi instrumentation techniques on the incidence of microcracks after the preparation of straight and curved root canals using micro‐CT. Roots from mandibular premolars and maxillary molars (n = 66) with the same mean canal curvatures were assigned to three groups of straight and three groups of curved roots (n = 11). After preoperative micro‐CT scans, root canals were prepared with Reciproc, OneShape and ProTaper Next to size 25. Specimens were scanned again, and pre‐ and post‐operative cross‐sectional images (n = 75 263) were screened to identify the presence of dentinal microcracks. Overall, microcracks were detected in 2.97% (n = 2236) of the cross‐sectional images. No new dentinal microcracks were observed after root canal instrumentation of straight and curved canals with the tested NiTi systems. Instrumentation with Reciproc, OneShape and ProTaper Next did not induce the formation of dentinal microcracks irrespective of canal curvature. 相似文献
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