全文获取类型
收费全文 | 526篇 |
免费 | 50篇 |
国内免费 | 8篇 |
专业分类
儿科学 | 19篇 |
妇产科学 | 11篇 |
基础医学 | 40篇 |
口腔科学 | 37篇 |
临床医学 | 72篇 |
内科学 | 154篇 |
皮肤病学 | 10篇 |
神经病学 | 37篇 |
特种医学 | 74篇 |
外科学 | 37篇 |
综合类 | 16篇 |
预防医学 | 22篇 |
眼科学 | 4篇 |
药学 | 40篇 |
肿瘤学 | 11篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2020年 | 3篇 |
2019年 | 5篇 |
2018年 | 5篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 10篇 |
2014年 | 11篇 |
2013年 | 24篇 |
2012年 | 8篇 |
2011年 | 12篇 |
2010年 | 23篇 |
2009年 | 19篇 |
2008年 | 16篇 |
2007年 | 27篇 |
2006年 | 4篇 |
2005年 | 9篇 |
2004年 | 12篇 |
2003年 | 9篇 |
2002年 | 8篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 8篇 |
1998年 | 22篇 |
1997年 | 36篇 |
1996年 | 34篇 |
1995年 | 21篇 |
1994年 | 24篇 |
1993年 | 20篇 |
1992年 | 9篇 |
1991年 | 11篇 |
1990年 | 8篇 |
1989年 | 15篇 |
1988年 | 16篇 |
1987年 | 13篇 |
1986年 | 19篇 |
1985年 | 14篇 |
1984年 | 6篇 |
1983年 | 18篇 |
1982年 | 20篇 |
1981年 | 15篇 |
1980年 | 7篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1975年 | 3篇 |
1972年 | 2篇 |
1960年 | 1篇 |
排序方式: 共有584条查询结果,搜索用时 15 毫秒
101.
102.
103.
104.
105.
106.
107.
Congenital radioulnar synostosis(CRS) is a rare anomaly and approximately 400 cases were reported worldwide so far. CRS is the failure of the longitudinal segmentation and the persistence of the cartilaginous anlage between the radius and ulna during the seventh week of development that results in a persistent bridge of tissue. Here we are discussing on a case of 25yrs old, male patient with bilateral congenital synostosis. On the left hand the pronation and supination movements are restricted completely where as on right side 10 degree of supination and 20 degree of pronation is possible. Radiologically in our patient synostosis is classified as type II variety by Wilkie(1914)1 classification and type IV by the Cleary and Omer classification(1985). The position of forearm was not found to be related to subjective functional limitation, or employment status. Main line of treatment is surgical mainly rotational osteotomy but is rarely indicated. Our patient is not able to rotate his forearm especially on the left side still he has no functional limitation so he has refused for the operative treatment. No study has objectively compared the preoperative functional limitation of the patients with their postoperative functional improvement in order to justify surgical intervention In the authors opinion the only major factor that is to be taken into consideration of operative treatment is functional limitation to the patient. 相似文献
108.
J Tiernan CD Briggs GRB Irving MT Swinscoe M Peterson IC Cameron 《Annals of the Royal College of Surgeons of England》2010,92(3):225-230
INTRODUCTION
In 2004, an audit in our unit demonstrated wide variation in liver resection rates for colorectal cancer (CRC) metastases within the cancer network. Subsequently, a network-wide CT-based follow-up and referral policy was introduced for all patients. A second audit was performed to assess the impact of the guidelines on liver resection rates.SUBJECTS AND METHODS
Analysis of prospective liver resection database between 1997 and 2004 and after the introduction of standardised guidelines between January 2005 and April 2008.RESULTS
A total of 362 patients underwent liver resection for CRC metastases between 1997 and 2008, 237 prior to the introduction of the referral guidelines and 125 after. Liver resection rates according to referring hospital varied from 0.92 to 2.32 per 100,000 population before guidelines were introduced. After 2005, resection rates from the four district hospitals standardised (1.68–1.84 per 100,000 population), but the central unit rate (Sheffield) remained significantly higher (2.67 per 100,000 population). No significant difference in 1-year disease-free survival between patients from Sheffield and the outlying hospitals was found (P = 0.553).CONCLUSIONS
Introduction of a referral protocol standardised resection rates from the four district hospitals, but these remain lower compared to the specialist centre. The wide-spread adoption of a policy to discuss all patients with liver metastases at an advanced disease multidisciplinary team meeting, in the presence of hepatobiliary specialists, may further increase resection rates across the UK. 相似文献109.
110.
CJH Kramer L Lanjouw D Ruano A ter Elst G Santandrea N Solleveld-Westerink N Werner AH van der Hout CD de Kroon T van Wezel LPV Berger M Jalving J Wesseling VTHBM Smit GH de Bock CJ van Asperen MJE Mourits MPG Vreeswijk J Bart T Bosse 《The Journal of pathology》2024,262(2):137-146
The identification of causal BRCA1/2 pathogenic variants (PVs) in epithelial ovarian carcinoma (EOC) aids the selection of patients for genetic counselling and treatment decision-making. Current recommendations therefore stress sequencing of all EOCs, regardless of histotype. Although it is recognised that BRCA1/2 PVs cluster in high-grade serous ovarian carcinomas (HGSOC), this view is largely unsubstantiated by detailed analysis. Here, we aimed to analyse the results of BRCA1/2 tumour sequencing in a centrally revised, consecutive, prospective series including all EOC histotypes. Sequencing of n = 946 EOCs revealed BRCA1/2 PVs in 125 samples (13%), only eight of which were found in non-HGSOC histotypes. Specifically, BRCA1/2 PVs were identified in high-grade endometrioid (3/20; 15%), low-grade endometrioid (1/40; 2.5%), low-grade serous (3/67; 4.5%), and clear cell (1/64; 1.6%) EOCs. No PVs were identified in any mucinous ovarian carcinomas tested. By re-evaluation and using loss of heterozygosity and homologous recombination deficiency analyses, we then assessed: (1) whether the eight ‘anomalous’ cases were potentially histologically misclassified and (2) whether the identified variants were likely causal in carcinogenesis. The first ‘anomalous’ non-HGSOC with a BRCA1/2 PV proved to be a misdiagnosed HGSOC. Next, germline BRCA2 variants, found in two p53-abnormal high-grade endometrioid tumours, showed substantial evidence supporting causality. One additional, likely causal variant, found in a p53-wildtype low-grade serous ovarian carcinoma, was of somatic origin. The remaining cases showed retention of the BRCA1/2 wildtype allele, suggestive of non-causal secondary passenger variants. We conclude that likely causal BRCA1/2 variants are present in high-grade endometrioid tumours but are absent from the other EOC histotypes tested. Although the findings require validation, these results seem to justify a transition from universal to histotype-directed sequencing. Furthermore, in-depth functional analysis of tumours harbouring BRCA1/2 variants combined with detailed revision of cancer histotypes can serve as a model in other BRCA1/2-related cancers. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. 相似文献