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101.
GL Moore ; DH Marks ; RA Carmen ; ME Ledford ; EJ Nelson ; RJ Fishman ; BS Leng 《Transfusion》1988,28(3):221-225
A red cell additive solution (AS-005) containing ascorbate-2-phosphate (AsP) to maintain 2,3-diphosphoglycerate, plus adenine, phosphate, and mannitol to retain viability and reduce hemolysis, was evaluated by human clinical trials. A crossover design was used with another additive solution (Nutricel AS-3, Cutter Laboratories) serving as the control for each donor. Each additive solution was evaluated at 35 and 42 days of storage. There was no significant difference between the red cell viability of the two storage solutions at either time period. Split-bag, AS-005 in vitro studies at two temperatures (2.5 and 5.5 degrees C), both within the range of 1 to 6 degrees C approved by the American Association of Blood Banks and the Food and Drug Administration, resulted in dramatically different in vitro parameters, including a threefold difference in 2,3-diphosphoglycerate (2,3-DPG), a fivefold difference in glucose, and significant differences in pH and adenosine triphosphate. High-pressure liquid chromatography data confirmed the preliminary report that 1 to 2 percent (wt/wt) oxalate was present in preparations of AsP. In vitro storage data confirmed that oxalate is the active component of AsP that preserves 2,3-DPG during storage. 相似文献
102.
Despite linkages between physical and sexual abuse experienced by children and adolescents and subsequent emotional, behavioral and mental disorders, no prior studies have examined the sexual or physical abuse histories occurring among young clients receiving outpatient mental health services. In the present chart review study, a high prevalence of documented and suspected abuse histories were found, with significant differences among male and female, and black and white outpatients, with respect to types of abuse experienced. Recommendations regarding further investigations in this area are discussed. 相似文献
103.
小藤铃儿草的生物碱成分 总被引:1,自引:0,他引:1
自小藤铃儿草Dactylicapnos torulosa(Hook.f ct Thomas.)Hutchins中分得六个单体,通过UV,IR,MS,~1HNMR和~(13)CNMR解析,鉴定了四个,其中一个为新化合物,命名为紫金龙碱(zijinlongine,Ⅰ),其他三个为已知化合物:氯化1-甲氧基小檗碱(1-methoxylberberium chloride,Ⅱ),氯化三乙基苯胺(triethylphcnylamium chloride,Ⅲ)和异紫堇定(isocorydine,Ⅳ)。Ⅱ和Ⅲ系首次从植物中得到。 相似文献
104.
A family showing inheritance of the Inab phenotype 总被引:2,自引:0,他引:2
An 86-year-old white American woman was found to have a very rare red cell phenotype, the Inab phenotype. Her cells were Cr(a-), Tc(a-b-c-), Dr(a-), Es(a-), WES(a-b-), and IFC-. Unlike the two other Inab phenotype patients, she has no history of protein-losing enteropathy or any similar intestinal disorder. One of her four siblings also has the Inab phenotype, providing the first evidence that this phenotype may be inherited. Serum inhibitions showed that anit-Cra, -TCa, -Dra, -WESb, and -IFC are partially inhibited by sera from three siblings with the common red cell phenotype but not by serum from the Inab phenotype sibling. The serum of the proposita contained an antibody to a high-frequency antigen that showed characteristics of being a Cromer-related antibody. 相似文献
105.
Hemimegalencephaly: MR imaging in five children 总被引:5,自引:0,他引:5
Kalifa GL; Chiron C; Sellier N; Demange P; Ponsot G; Lalande G; Robain O 《Radiology》1987,165(1):29-33
Hemimegalencephaly is a rare brain malformation characterized by cerebral asymmetry and cortical dysplasia. Infants with the condition present with early seizures and severe encephalopathy. Five patients were studied with computed tomography and magnetic resonance (MR) imaging. MR imaging was the most efficient diagnostic method for this rare entity. It demonstrated brain hemispheric hypertrophy with lateral ventricle dilatation, abnormal gyral pattern, and a thick cortex on the enlarged side. The images correlate well with the known pathologic data. 相似文献
106.
To determine the appearance of artifactual renal duplication in ultrasound (US) imaging, the authors analyzed 22 examples of such duplication in 20 patients. The artifact appeared as a duplication of the collecting system in 18, as a suprarenal mass in three, and as upper-pole cortical thickening in one. It occurred in the left kidney in 15 patients, in the right kidney in three, and bilaterally in two. To determine the frequency of the artifact, 50 additional patients were scanned. It was identified in eight of these patients. Imaging characteristics and the results of in vitro modeling proved the artifact was due to sound beam refraction between the lower pole of the spleen or liver and adjacent fat. This artifact is much more common in the left kidney and occurs more frequently in obese patients. Knowledge of the appearance and cause of this artifact should help radiologists avoid diagnostic errors. 相似文献
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110.
Reported are the results of two uncontrolled outcome studies that evaluate the effectiveness of inpatient psychiatric treatment of children and adolescents suffering from clinical depression. Study 1 employed a sample of 7 children and measured outcome with the Depression Self-rating Scale (DSRS), the Hopelessness Scale for Children (HSC), and the Global Asssessment of Functioning (GAF) scale, which were administered to each child upon admission and again at discharge. Inpatient treatment involved multiple interventions, including individual psychotherapy, medication, milieu therapy and token economy, and other procedures. At discharge, statistically significant improvements were found on the patients' GAF and HSC scores, but not on their DSRS scores. Study 2 used a sample of 15 adolescents, also admitted for clinical depression. Administered at each patient's admission and discharge, the Beck Depression Inventory (BDI), Generalized Contentment Scale (GCS), and Index of Self-esteem (ISE) were used to measure outcome. The multi-modal treatment program offered to the sample in Study 2 was similar to that offered the sample in Study 1. At discharge all three outcome measures reflected statistically significant improvements in the patients studies; therefore, these results provide addmtional support for the inpatient treatment of depressed children and adolescents. 相似文献