全文获取类型
收费全文 | 3485篇 |
免费 | 113篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 41篇 |
儿科学 | 39篇 |
妇产科学 | 44篇 |
基础医学 | 459篇 |
口腔科学 | 117篇 |
临床医学 | 192篇 |
内科学 | 913篇 |
皮肤病学 | 49篇 |
神经病学 | 182篇 |
特种医学 | 115篇 |
外科学 | 713篇 |
综合类 | 4篇 |
预防医学 | 87篇 |
眼科学 | 32篇 |
药学 | 241篇 |
中国医学 | 8篇 |
肿瘤学 | 384篇 |
出版年
2023年 | 8篇 |
2022年 | 24篇 |
2021年 | 43篇 |
2020年 | 29篇 |
2019年 | 42篇 |
2018年 | 41篇 |
2017年 | 35篇 |
2016年 | 49篇 |
2015年 | 57篇 |
2014年 | 81篇 |
2013年 | 91篇 |
2012年 | 211篇 |
2011年 | 191篇 |
2010年 | 130篇 |
2009年 | 95篇 |
2008年 | 198篇 |
2007年 | 202篇 |
2006年 | 186篇 |
2005年 | 251篇 |
2004年 | 213篇 |
2003年 | 238篇 |
2002年 | 246篇 |
2001年 | 61篇 |
2000年 | 73篇 |
1999年 | 75篇 |
1998年 | 69篇 |
1997年 | 46篇 |
1996年 | 58篇 |
1995年 | 58篇 |
1994年 | 47篇 |
1993年 | 42篇 |
1992年 | 44篇 |
1991年 | 29篇 |
1990年 | 30篇 |
1989年 | 29篇 |
1988年 | 27篇 |
1987年 | 29篇 |
1986年 | 27篇 |
1985年 | 18篇 |
1984年 | 15篇 |
1983年 | 24篇 |
1982年 | 19篇 |
1981年 | 15篇 |
1980年 | 13篇 |
1979年 | 12篇 |
1978年 | 9篇 |
1977年 | 12篇 |
1976年 | 8篇 |
1975年 | 14篇 |
1972年 | 10篇 |
排序方式: 共有3620条查询结果,搜索用时 0 毫秒
61.
Arrecubieta C Matsunaga I Asai T Naka Y Deng MC Lowy FD 《The Journal of infectious diseases》2008,198(4):571-575
Staphylococcus aureus is a leading cause of ventricular assist device-related infections. This study evaluated the protective effect against S. aureus infection of active and passive immunization that targeted 3 proteins involved in bacterial attachment to a murine intra-aortic polyurethane patch. Active immunization of mice with a combination of the A domains of clumping factor A (ClfA), fibronectin-binding protein A (FnBPA) and fibronectin-binding protein B or passive immunization with monoclonal antibodies against ClfA and FnBPA resulted in a higher level of protection than that obtained by vaccination with either protein or antibody alone. The combination of antibodies or protein antigens appears to provide enhanced protection against prosthetic-device infection. 相似文献
62.
Yoshitama T Nakamura M Tsunoda T Kitagawa Y Shiba M Yajima S Wada M Iijima R Nakajima R Takagi T Anzai H Nishida T Yamaguchi T 《Coronary artery disease》2004,15(4):187-193
OBJECTIVE: Insulin resistance has been implicated as an important initiating factor in coronary atherosclerosis. However, associations between insulin resistance and specific morphologic features of atherosclerotic coronary arteries remain unclear. We ultrasonographically evaluated the morphologic features of atherosclerotic coronary arteries in nondiabetic patients with insulin resistance. METHODS: Before intervention, 90 patients with 105 culprit lesions underwent intravascular ultrasound examination through which vessel area, lumen area and plaque area were evaluated. Expansive remodeling (lesion vessel area more than 5% greater than at the proximal reference segment) and constrictive remodeling (lesion vessel area more than 5% less than at the distal reference segment) were also evaluated. Insulin resistance was determined by homeostasis model assessment and defined as values above the 75th percentile (that is, 1.71). RESULTS: Insulin-resistant patients numbered 23, while nonresistant patients numbered 67. Culprit lesions in the insulin-resistant group showed larger vessel area (18.16 +/- 6.94 compared with 13.64 +/- 4.28 mm, P = 0.0001) and plaque area (16.64 +/- 6.78 compared with 12.05 +/- 4.12 mm, P = 0.0001) and more frequently showed expansive remodeling (56% compared with 14%, P < 0.0001) and calcific plaque (33% compared with 12%, P = 0.01). Multivariable logistic regression analysis identified only insulin resistance (odds ratio, 4.9, P = 0.008) as an independent predictor of expansive remodeling. CONCLUSIONS: Insulin resistance independently predicted expansive remodeling, underscoring the importance of insulin resistance in coronary atheroscrelosis. 相似文献
63.
Satoko Kojima Kei Kawana Kensuke Tomio Aki Yamashita Ayumi Taguchi Shiho Miura Katsuyuki Adachi Takeshi Nagamatsu Kazunori Nagasaka Yoko Matsumoto Takahide Arimoto Katsutoshi Oda Osamu Wada‐Hiraike Tetsu Yano Yuji Taketani Tomoyuki Fujii Danny J. Schust Shiro Kozuma 《American journal of reproductive immunology (New York, N.Y. : 1989)》2013,69(2):134-141
64.
Prevalence and Significance of Clinically Unsuspected Pulmonary Embolism: Detection Using Coronary Computed Tomography Angiography 下载免费PDF全文
65.
66.
Do testosterone levels have prognostic significance in patients with metastatic prostate cancer treated with combined androgen blockade? 下载免费PDF全文
67.
68.
69.
70.
In situ Ca2+ dynamics of Purkinje fibers and its interconnection with subjacent ventricular myocytes
Hamamoto T Tanaka H Mani H Tanabe T Fujiwara K Nakagami T Horie M Oyamada M Takamatsu T 《Journal of molecular and cellular cardiology》2005,38(4):561-569
Purkinje fibers play essential roles in impulse propagation to the ventricles, and their functional impairment can become arrhythmogenic. However, little is known about precise spatiotemporal pattern(s) of interconnection between Purkinje-fiber network and the underlying ventricular myocardium within the heart. To address this issue, we simultaneously visualized intracellular Ca(2+) dynamics at Purkinje fibers and subjacent ventricular myocytes in Langendorff-perfused rat hearts using multi-pinhole type, rapid-scanning confocal microscopy. Under recording of electrocardiogram at room temperature spatiotemporal changes in fluo3-fluorescence intensity were visualized on the subendocardial region of the right-ventricular septum. Staining of the heart with either fluo3, acetylthiocholine iodide (ATCHI), or di-4-ANEPPS revealed characteristic structures of Purkinje fibers. During sinus rhythm (about 60 bpm) or atrial pacing (up to 3 Hz) each Purkinje-fiber exhibited spatiotemporally synchronous Ca(2+) transients nearly simultaneously to ventricular excitation. Ca(2+) transients in individual fibers were still synchronized within the Purkinje-fiber network not only under high-K(+) (8 mM) perfusion-induced Purkinje-to-ventricular (P-V) conduction delay, but also under unidirectional, orthodromic P-V block produced by 10-mM K(+) perfusion. While spontaneous, asynchronous intracellular Ca(2+) waves were identified in injured fibers of Purkinje network locally, surrounding fibers still exhibited Ca(2+) transients synchronously to ventricular excitation. In summary, these results are the first demonstration of intracellular Ca(2+) dynamics in the Purkinje-fiber network in situ. The synchronous Ca(2+) transients, preserved even under P-V conduction disturbances or under emergence of Ca(2+) waves, imply a syncytial role of Purkinje fibers as a specialized conduction system, whereas unidirectional block at P-V junctions indicates a substrate for reentrant arrhythmias. 相似文献