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91.
Roshan Mahabir Mishie Tanino Aiman Elmansuri Lei Wang Taichi Kimura Tamio Itoh Yusuke Ohba Hiroshi Nishihara Hiroki Shirato Masumi Tsuda Shinya Tanaka 《Neuro-oncology》2014,16(5):671-685
Background
Ionizing irradiation is an effective treatment for malignant glioma (MG); however, a higher rate of recurrence with more aggressive phenotypes is a vital issue. Although epithelial-mesenchymal transition (EMT) is involved in irradiation-induced cancer progression, the role for such phenotypic transition in MG remains unknown.Methods
To investigate the mechanism of irradiation-dependent tumor progression in MG, we performed immunohistochemistry (IHC) and qRT-PCR using primary and recurrent MG specimens, MG cell lines, and primary culture cells of MG. siRNA technique was used for MG cell lines.Results
In 22 cases of clinically recurrent MG, the expression of the mesenchymal markers vimentin and CD44 was found to be increased by IHC. In paired identical MG of 7 patients, the expression of collagen, MMPs, and YKL-40 were also elevated in the recurrent MGs, suggesting the The Cancer Genome Atlas-based mesenchymal subtype. Among EMT regulators, sustained elevation of Snail was observed in MG cells at 21 days after irradiation. Cells exhibited an upregulation of migration, invasion, numbers of focal adhesion, and MMP-2 production, and all of these mesenchymal features were abrogated by Snail knockdown. Intriguingly, phosphorylation of ERK1/2 and GSK-3β were increased after irradiation in a Snail-dependent manner, and TGF-β was elevated in both fibroblasts and macrophages but not in MG cells after irradiation. It was noteworthy that irradiated cells also expressed stemness features such as SOX2 expression and tumor-forming potential in vivo.Conclusions
We here propose a novel concept of glial-mesenchymal transition after irradiation in which the sustained Snail expression plays an essential role. 相似文献92.
Satoshi Okayama Tomoya Nakano Shiro Uemura Shinichi Fujimoto Satoshi Somekawa Makoto Watanabe Tamio Nakajima Yoshihiko Saito 《Journal of cardiovascular magnetic resonance》2013,15(1):87
Background
Evaluation of left ventricular (LV) diastolic function is essential for the management of heart failure. We verified whether LV diastolic function could be evaluated by measuring the fractional area change (FAC) using cine cardiovascular magnetic resonance (CMR).Methods
We collected clinical data from 59 patients who underwent echocardiography and cine CMR. Normal, impaired relaxation, pseudonormal, and restrictive LV filling were observed in 15, 28, 11, and 5 patients, respectively. We calculated FAC during the first 30% of diastole (diastolic-index%) in the short-axis view, by tracing the contours on only three MR cine images.Results
The diastolic index was significantly lower (p < 0.0001) in patients with impaired relaxation (32.4 ± 7.5), pseudonormal filling (25.4 ± 5.6), and restrictive filling (9.5 ± 1.5) compared to those with normal diastolic function (67.7 ± 10.8), and the index decreased significantly with worsening of diastolic dysfunction. The diastolic index correlated positively with early diastolic mitral annular velocity measured by tissue Doppler imaging (r = 0.75, p < 0.0001), respectively.Conclusions
Measurement of FAC can be useful for the evaluation of LV diastolic function using cine CMR. 相似文献93.
Mashimo Y Maeda T Teramoto T 《Nihon rinsho. Japanese journal of clinical medicine》2012,70(5):852-856
Low-density lipoprotein (LDL) cholesterol is the most established risk factor for atherosclerotic disease such as coronary artery disease and cerebrovascular disease. High-density lipoprotein (HDL) cholesterol and nonHDL-C as well as small dense LDL, Remnant like particles cholesterol (RLP-C) and oxidized LDL are the secondary risk factors for atherosclerosis. It is important to integrate and control these risk factors for the prevention of atherosclerosis as a real endpoint of diagnosis and treatment of dyslipidemia. 相似文献
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97.
Guide for medical professionals (i.e. dermatologists) for the management of Rhododenol‐induced leukoderma
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Chikako Nishigori Yumi Aoyama Akiko Ito Kayoko Suzuki Tamio Suzuki Atsushi Tanemura Masaaki Ito Ichiro Katayama Naoki Oiso Yuji Kagohashi Shinichi Sugiura Kazuyoshi Fukai Yoko Funasaka Toshiharu Yamashita Kayoko Matsunaga 《The Journal of dermatology》2015,42(2):113-128
Because some users develop depigmentation after the use of melanogenesis‐inhibiting products containing the quasi‐drug ingredient Rhododenol, Japanese Dermatological Association (JDA) established a Special Committee on the Safety of Cosmetics Containing Rhododenol on July 17, 2013 and management guide for dermatologists has been updated on the website in order to delineate the diagnostic criteria for Rhododenol‐induced leukoderma and provides a broad guide for standard treatment based on current knowledge. This guide is produced on the basis of the guide (version 7) updated on June 20, 2014 in the website. Rhododenol‐induced leukoderma refers to depigmentation of varying severity that develops after the use of cosmetics containing Rhododenol, mainly at the site of use. In most cases, repigmentation of part or all the affected area is evident after discontinuation. Histopathologically cellular infiltration around the hair follicles and melanophages are present in most cases. The number of melanocytes in the lesion is declined but not totally absent in most cases. Rhododenol itself is a good substrate for tyrosinase, resulting in the formation of Rhododenol metabolites (e.g., Rhododenol quinone). Melanocytes are damaged by Rhododenol metabolites during the subsequent metabolic process. The continued use of cosmetics containing Rhododenol thus induces tyrosinase activity‐dependent cytotoxicity in melanocytes in the epidermis at application sites, resulting in decreasing the amount of melanin produced by melanocytes; the addition of some other factor to this process is believed to subsequently cause the decrease or disappearance of melanocytes themselves from the epidermis. 相似文献
98.
Sakai S Akiyama H Harikai N Toyoda H Toida T Maitani T Imanari T 《Immunology letters》2002,81(3):211-216
Precursors for Thy-1(+) dendritic epidermal T cells (DETC) develop as Vgamma3(+) T cells in the fetal thymus and become distributed in the adult skin. DETC are variably distributed from site to site and from strain to strain. To elucidate the basis of strain variation, we first compared the density of DETC in the ear epidermis among different mouse strains. In the ear epidermis, we detected the highest level of DETC in C57BL/6 mice, intermediate levels in C3H and CBA/J mice, and the lowest levels in other strains including BALB/c and 129 mice. Although BALB/c and 129+Ter/Sv mice showed higher levels of DETC in the abdomen than in the ear, the levels were significantly lower than C57BL/6 mice. Furthermore, in neonatal abdominal epidermis we detected considerably lower numbers of DETC in BALB/c and 129+Ter/Sv mice than in C57BL/6 mice. In contrast, Vgamma3(+) DETC precursors in the fetal thymus are rather increased in 129+Ter/Sv mice. These results suggest that fewer DETC precursors are seeded in the neonatal skin of BALB/c and 129+Ter/Sv mice and that their expansion in the skin during neonatal to adult stages does not reach the levels in C57BL/6 mice. 相似文献
99.
Ieiri T 《Rinsho byori. The Japanese journal of clinical pathology》2001,49(4):311-318
Major thyroid diseases and recent progress in thyroid research are reviewed, including our clinical experiences and data on genetic analysis. Of the 19,944 patients receiving care in our endocrinology and metabolism department over the past 26 years(from 1974 to 2000), there were 4,471(22.4%) patients with thyroid diseases. Of these patients with thyroid disease, 37.3% had Graves' disease, 24.1% had Hashimoto's thyroiditis, and 22.2% had a benign thyroid tumor. Male-to-female ratio for Graves' disease was 1:3.2. The precise mechanism and genetic or environmental factors underlying the onset and progression of autoimmune thyroid disease need further investigation, although recent thyroid research, especially molecular level studies, has resulted in many new insights. Our genetic analysis of patients and experimental animals with thyroglobulin(Tg) abnormalities indicated the amino acids involved in the surface electric charge were important in maintaining the solid structure of Tg and thyroid hormone synthesis in addition to tyrosine and cysteine. In three patients with hyperthyroid Graves' disease, Hashimoto's thyroiditis or idiopathic hypothyroidism, followed by the author for 8 to 20 years, it was indicated that continued comprehensive care was needed for various episodes, even those arising from non-endocrine conditions, throughout the clinical course, although clinical and laboratory findings showed improvement of the thyroid disease itself. 相似文献
100.
Akihito Yashima Masashi Mizuno Yukio Yuzawa Koki Shimada Norihiko Suzuki Hideo Tawada Waichi Sato Naotake Tsuboi Shoichi Maruyama Yasuhiko Ito Seiichi Matsuo Tamio Ohno 《Clinical and experimental nephrology》2017,21(4):589-596