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41.
Nishida Hayato Fukuhara Hiroki Nawano Takaaki Kanno Hidenori Yagi Mayu Yamagishi Atsushi Sakurai Toshihiko Naito Sei Kato Tomoyuki Kudo Kosuke Ichikawa Kazunobu Tsuchiya Norihiko 《Clinical and experimental nephrology》2021,25(12):1346-1353
Clinical and Experimental Nephrology - Arteriovenous fistula (AVF) is the most preferred vascular access for hemodialysis patients, and early failure of AVF is one of the most avoidable... 相似文献
42.
The effects of unilateral sciatic neurectomy (USN) on the development of the femur were studied in 15 growing Wistar-derived
rats (age, 5 weeks). The rats were divided into four groups: USN-operated group (right femur), USN-nonoperated group (left
femur), sham-operated group (right femur), and sham-nonoperated group (left femur). Bone mineral density (BMD), bone mineral
content (BMC), bone area, periosteal circumference, and endosteal circumference were measured by peripheral quantitative computed
tomography (pQCT) and the mineral/matrix ratio was evaluated by Fourier transform infrared spectroscopy (FTIR). The USN-operated
group showed a significant decrease in cortical BMC, bone area, and periosteal circumference compared with the other groups
(P < 0.05). The cortical BMD did not vary significantly between the groups. In the cancellous bone, the USN-operated group showed
a significant decrease in BMD and BMC at the metaphysis compared with the other groups (P < 0.05). The mineral/matrix ratio of the cortical bone did not differ significantly between the USN-operated and USN-nonoperated
groups. These results suggest that in cortical bone, USN inhibits periosteal bone formation but has no significant effect
on the mineral/matrix ratio of cortical bone in femurs. In cancellous bone, USN induces bone loss at the metaphysis.
Received: Nov. 19, 1998 / Accepted: Feb. 12, 1999 相似文献
43.
Characteristics of bone mineral density and soft tissue composition of obese Japanese women: Application of dual-energy X-ray absorptiometry 总被引:2,自引:0,他引:2
We studied the characteristics of bone mineral density (BMD) and soft tissue composition in obese Japanese women using dual-energy
X-ray absorptiometry. Eighty-nine women, aged 45–85 years, were divided into three groups according to their body mass index
(BMI): a thin group (n = 38; BMI < 21), a standard weight group (n = 31; BMI, 21–25), and an obese group (n = 20; BMI ≥ 25). The mean BMD of the second to fourth lumbar vertebrae and BMD of the lumbar spine, thoracic spine, pelvis,
legs, and ribs of the thin group were significantly lower than those of the standard weight group or the obese group (P < 0.05), whereas no significant difference in total body BMD was observed among the three groups. There was a significant
difference in total and regional fat mass among the three groups (P < 0.05). Lean mass of legs and total lean mass showed a significant difference between the thin group and the obese group
(P < 0.05). The results showed that obesity was associated with higher BMD of weight bearing-bones and ribs, high total and
regional fat mass, and high lean mass of bilateral legs and total lean mass. We suggest that obesity may contribute to the
prevention of bone loss of weight-bearing bones and ribs and muscular atrophy of the legs.
Received: Sept. 30, 1998 / Accepted: Dec. 10, 1998 相似文献
44.
Relationship between autofluorescence and advanced glycation end products in diabetic lenses 总被引:1,自引:0,他引:1
Abiko T Abiko A Ishiko S Takeda M Horiuchi S Yoshida A 《Experimental eye research》1999,68(3):361-366
Autofluorescence and advanced glycation end product (AGE) levels were measured in the lenses of 9 diabetic Chinese hamsters and 6 age-matched controls. Lens autofluorescence also was measured in 37 diabetic patients and 14 age-matched controls. Lens autofluorescence values were measured noninvasively with a lens measurement system using color filters with peak transmission at 365- and 434-nm wavelengths (excitation and emission, respectively) that are characteristic of AGE fluorescence. The peak lens autofluorescence level was used as the lens autofluorescence value, and the mean lens autofluorescence values from both eyes of each subject were used for statistical analysis. The AGE levels in one lens from each hamster were measured by noncompetitive enzyme-linked immunosorbent assay with a polyclonal anti-AGE antibody. We found a 2.2 times increase of the mean lens autofluorescence value of diabetic hamsters in comparison with that of controls (P<0.01). We also found a 1.5 times increase of the mean AGE level from the lenses of diabetic hamsters in comparison with that of controls (P<0.01). Moreover, a statistically significant positive correlation between the AGE level and autofluorescence value in the same lenses was observed in all hamsters (rho=0.58, P<0.05). In human subjects, we found a 1.4 times increase of the mean lens autofluorescence value of diabetic patients in comparison with that of age-matched controls (P<0.01). Our results suggest that non invasive measurement of lens autofluorescence may be a guide to AGE levels in lenses. 相似文献
45.
Sakakibara H Zhu SK Furuta M Kondo T Miyao M Yamada S Hideaki T 《Environmental health and preventive medicine》1996,1(3):114-118
Factors associated with knee pain were investigated using 871 self-administered questionnaires (405 men and 466 women) from
residents aged over 30 years in a rural area of Japan. The prevalence of knee pain increased with age, particularly in women
over 50. It was significantly higher in women than in men. Body mass index (BMI) was significantly related to knee pain in
women, though not in men. With reference to occupational factors, frequent heavy lifting on the job was significantly associated
with knee pain in both men and women, whereas job-related standing and walking showed no such relationship. As for living
conditions, residence on rather steep mountain slopes and the habit of sitting on Japanese tatami mats were significant factors
related to knee pain in men, but not in women. There was no association of knee pain with the style of toilet (Japanese or
Western). After controlling for all significant factors by multiple logistic regression analysis, age, heavy lifting, and
residence on steep slopes were found to be independent factors related to knee pain in men; and age, BMI, and heavy lifting
were the factors in women. 相似文献
46.
Fujino S Tezuka N Sawai S Konishi T Inoue S Kato H Mori A Okabe H 《Breast cancer (Tokyo, Japan)》1996,3(3):205-208
A case of glycogen-rich clear cell carcinoma (GRCC) which arose in the right breast of a 35-year-old Japanese woman is reported. Light microscopic examination of the tumor revealed solid alveolar proliferation of clear cells containing abundant glycogen. Electron microscopy identified aggregates of glycogen particles and numerous empty glycogen lakes. This case is reported with a discussion on the other 42 GRCC cases reported in the international literature. 相似文献
47.
Hideo Iwasaka Kouji Itoh Hiroshi Miyakawa Takaaki Kitano Kazuo Taniguchi Natsuo Honda 《Journal canadien d'anesthésie》1996,43(10):1059-1061
Purpose
The effects of prolonged sevoflurane anaesthesia on insulin sensitivity were investigated by two successive intravenous glucose tolerance tests (IVGTT) in eight patients who underwent prolonged surgery.Methods
The first IVGTT was administered (25 g glucose as 20% dextrose in water iv) over two minutes 35 min after initiation of surgery. Arterial blood samples were obtained at 0, 5, 10, 30, 60, and 120 min after glucose administration for blood glucose and plasma insulin determination. A second IVGTT was performed six hours following the initiation of surgery.Results
The disappearance rate of glucose (k-value) for the first IVGTT was 0.887 ± 0.436 (mean ± SD) % · min?1, and 0.784 ± 0.289 for the second IVGTT. Both k-values are lower than the normal value. The maximum insulin response to glucose (ΔIRI · ΔBS?1) of the second IVGTT was lower than the first IVGTT (0.124 ± 0.092 vs 0.071 ± 0.056, P < 0.05). The total insulin output of the first IVGTT was higher than the second IVGTT (1,161 ± 830 vs 568 ± 389 μU · min · ml?1, P < 0.05).Conclusion
Glucose intolerance is enhanced by diminished insulin output in response to blood glucose elevation during prolonged anaesthesia and surgery. 相似文献48.
Hiroshi Arai Takaaki Beppu Tukasa Wada Yuuki Yoshida Yoshitaka Kubo Michiyasu Suzuki Akira Ogawa 《Brain tumor pathology》1998,15(1):37-40
We investigated factors of the early recurrence and malignant transformation of histologically benign meningiomas using immunohistochemistry
for MIB-1 positive indices (PI) and p53 protein expression, a flow cytometric DNA analysis, and the examination of numerical
chromosomal aberrations detected by fluorescence in situ hybridization using an α-satellite DNA probe and abcr gene locus-specific probe. Twenty-six meningiomas of 23 patients were classified into two groups: the 3 patients in whom
a recurrence was defined within two years after initial surgery and who showed histologically malignant features were classified
as the early recurrent group, and the other 20 patients in whom recurrence did not develop during the same period were classified
as the nonrecurrent group. DNA aneuploidy was observed in 40% of the nonrecurrent patients and in 67% of the early recurrent
patients. Loss of chromosome 22 was the most common numerical aberration, but the aberrations characteristic of early recurrent
meningiomas were not detected. The MIB-1 PI values of the early recurrent meningiomas were higher than those of nonrecurrent
meningiomas, suggesting that MIB-1 PI is very important for biological and histopathological analyses and prediction of the
future recurrence of meningiomas. 相似文献
49.
Microvascular decompression for cochlear symptoms 总被引:4,自引:0,他引:4
Okamura T Kurokawa Y Ikeda N Abiko S Ideguchi M Watanabe K Kido T 《Journal of neurosurgery》2000,93(3):421-426
OBJECT: The object of this study was to evaluate the efficacy of a new neurovascular decompression technique in relieving symptoms of cochlear nerve dysfunction. METHODS: Nineteen patients with slowly progressive hearing loss, low-frequency fluctuating hearing loss, and high-pitched tinnitus due to neurovascular compression (NVC) of the eighth cranial nerve in a triangular space between the seventh and eighth cranial nerves (the VII-VIII triangle) of the cerebellopontine angle (CPA) were treated using a new technique for microvascular decompression that was developed by anatomical study in 24 cadaver specimens of the CPA. In 12 of 19 patients the anterior inferior cerebellar artery (AICA) was observed to cause compression in the VII-VIII triangle and this vessel was easily mobilized medially for placement of a silicone sponge or Teflon cushion between the compressing artery and nerve. Postoperatively, hearing loss of 20 dB or more that was present in 11 of the 19 patients with NVC improved by more than 5 dB in seven (64%), including the patient with the most severe hearing loss. Of 18 patients presenting with tinnitus preoperatively, eight (44%) had no tinnitus and an additional nine (for a total of 94%) had good improvement in tinnitus after surgery and at long-term follow up. CONCLUSIONS: The microvascular decompression technique described is highly successful in treating symptoms due to direct or indirect compression of the cochlear nerve, with minimal risk of complications. Recordings of auditory brainstem responses confirmed the clinical diagnosis of NVC of the eighth cranial nerve and correlated with clinical results after microvascular decompression of the cochlear nerve. 相似文献
50.
Takaaki Imamura Osamu Yokosuka Tetsuhiro Chiba Tatso Kanda Hiroshige Kojima Kenichi Fukai Fumio Imazeki Miki Nishimura Yasushi Saito Hiromitsu Saisho 《Leukemia & lymphoma》2005,46(6):915-917
We report the case of a 52-year-old woman with hepatitis B virus (HBV) reactivation during treatment for chronic graft vs. host disease (GVHD) after peripheral bone marrow transplantation (PBSCT) to treat chronic myelocytic leukemia. She was given cyclosporine and prednisolone orally to treat chronic GVHD after PBSCT. Liver dysfunction first developed 25 months after transplantation with the appearance of hepatitis B s antigen (HBsAg), hepatitis B e antigen (HBeAg), and elevation of HBV-DNA up to 4.5 log copies/ml. Retrospective examination of her serum before PBSCT proved negative for HBsAg and HBeAg, and positive for anti-HBsAg, anti-HBeAg, anti-hepatitis B core antigen, and HBV-DNA (2.7 log copies/ml), showing that she was in a state of occult HBV infection. Nucleotide sequences of the HBV genome obtained from her serum showed no core promoter mutations at nt 1762 and 1764 and no pre-core mutation at nt 1896. Polymerase chain reaction-restriction fragment length polymorphism showed that she was infected with HBV genotype B. The administration of lamivudine, a nucleoside analog, improved her liver function and reduced HBV-DNA replication. We conclude that antiviral agents, such as lamivudine, are effective for treating hepatitis B reactivation during immunosuppressive treatment, such as for GVHD. The administration of a nucleoside analog before transplantation should also be considered in the light of HBV genotypes and mutations, even if HBsAg was negative and the viral load was low before transplantation. 相似文献