边防海岛战士心理健康状况及人格特征与应对方式的研究

目的了解边防海岛战士的心理健康状况,人格特征及应对方式的关系。方法采用症状自评量表(SCL-90)、艾森克个性问卷(EPQ)和简易应对方式问卷对960名边防海岛战士进行心理测试,了解他们心理健康状况,人格特征和应对方式特点及其影响因素。结果(1)边防海岛战士SCL-90各因子分均显著高于军人常模;(2)边防海岛战士应对方式与心理健康状况密切相关,积极应对方式与SCL-90某些因子相关,消极应对方式与SCL-90各因子均呈显著正相关(P<0.01);(3)边防海岛战士在面对应激时所采取的应对方式与人格特征密切相关,消极应对方式与人格问卷中的P分(精神质)和N分(神经质)有显著或高度显著正相关(P<0.01),积极应对方式与人格问卷中的P分(精神质)呈负相关,和E分(内外向)呈正相关。结论边防海岛战士心理健康状况差于军人总体水平,人格特征及应对方式对心理健康水平有较大影响。     

应对方式的干预对边防海岛军人心理健康的影响

目的通过改变边防海岛军人的应对方式来提高他们的心理健康水平,提高部队的战斗力。方法运用多种形式组合的综合心理干预对边防海岛军人的应对方式进行干预,选用症状自评量表(SCL-90)、简易应对方式量表对边防海岛军人行心理测量。结果采取综合心理干预的边防海岛军人的症状自评量表(SCL-90)各项因子分均低于未采取综合心理干预的边防海岛军人(P<0.01),与未采取综合心理干预的边防海岛军人相比较,采取综合心理干预的边防海岛军人更多地采取积极的应对方式(P<0.01)。结论通过综合心理干预,让边防海岛军人更多地采取积极的应对方式对待生活和对抗应激,对提高和维护边防海岛军人的心理健康水平,确保部队的战斗力具有积极的意义。     

The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury

Herbal and dietary supplements(HDS)-induced liver injury has been a great concern all over the world.Polygonum multiflorum Thunb.,a well-known Chinese herbal medicine,is recently drawn increasing attention because of its hepatotoxicity.According to the clinical and experimental studies,P.multiflorum-induced liver injury(PM-DILI)is considered to be immune-mediated idiosyncratic liver injury,but the role of immune response and the underlying mechanisms are not completely elucidated.Previous studies focused on the direct toxicity of PM-DILI by using animal models with intrinsic drug-induced liver injury(DILI).However,most epidemiological and clinical evidence demonstrate that PM-DILI is immune-mediated idiosyncratic liver injury.The aim of this review is to assess current epidemiological,clinical and experimental evidence about the possible role of innate and adaptive immunity in the idiosyncratic hepatotoxicity of P.multiflorum.The potential effects of factors associated with immune tolerance,including immune checkpoint molecules and regulatory immune cells on the individual’s susceptibility to PM-DILI are also discussed.We conclude by giving our hypothesis of possible immune mechanisms of PM-DILI and providing suggestions for future studies on valuable biomarkers identification and proper immune models establishment.     

抗生素微生物检定法中滴加抗生素溶液方法的研究

目的：探索一种加样方法,用于抗生素微生物检定法中滴加抗生素溶液。方法：根据抗生素微生物检定法实验原理,通过对加样误差来源的分析,比较实验生物统计结果,筛选最佳滴加溶液方法。结果与结论：用微量移液器加样,定量270μL（以下称本方法）,其速度快、间隔时间短、加样量准确、减少实验误差,生物检定统计可靠性测验获得较好的结果,是抗生素微生物检定法实验中较好的加样方法。     

One-year efficacy of tenofovir alafenamide in patients with chronic hepatitis B: An observational study

Non-inferior antiviral efficacy and better renal safety have been reported in chronic hepatitis B patients with tenofovir alafenamide (TAF) treatment. The experience in real-world clinical practice is limited.We aimed to explore the efficacy after 1-year TAF treatment.A total of 148 patients (42 HBeAg-positive and 106 HBeAg-negative) with TAF treatment ≥1 year were included. Virological suppression (<20 IU/mL or undetectable), HBsAg level, alanine aminotransferase (ALT) normalization (≤36 U/L), and estimated glomerular filtration rate (eGFR) were analyzed at 1 year. Multivariate logistic regression analysis was performed to determine the associated factors for virological suppression and ALT normalization.Virological suppression was achieved in 83% and the 1-year median decline of hepatitis B virus DNA was 5.18 log IU/mL. ALT normalization occurred in 75.7%. HBsAg level decreased at a median of 0.27 log IU/mL with significant difference from baseline (P < .001). Baseline ALT (odds ratio [OR] 1.005, 95% confidence interval [CI] 1.000–1.010, P = .036) and hepatitis B virus DNA (OR 0.222, 95% CI 0.079–0.621, P = .004) were significant factors for 1-year virological suppression. Age (OR 1.064, 95% CI 1.003–1.130, P = .041) was associated with ALT normalization. Significant changes were observed in creatinine (mean increase 0.03 mg/dL, P = .011) and eGFR (mean decrease 2.6 mL/min/1.73 m², P = .004) after 1-year TAF treatment.One-year TAF treatment came to good virological response, modest ALT normalization rate and significant HBsAg decline. The observation of significant changes in eGFR warranted further studies.     

HPLC法测定蒲参胶囊中2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷的含量

目的：建立蒲参胶囊中2,3,5,4′-四羟基二苯乙烯-2-O-β-D-葡萄糖苷含量的HPLC测定方法。方法：采用Agilent C18柱（4.6mm×250mm,5μm）,流动相为乙腈-水（17∶83）,检测波长为320 nm。结果：2,3,5,4′-四羟基二苯乙烯-2-O-β-D-葡萄糖苷在0.0320～0.9606μg范围内呈线性关系（r＝1.0000）,平均回收率为96.6％（n＝6）,RSD为1.3％。结论：所建方法简便、准确,可用于该制剂的质量控制。