全文获取类型
收费全文 | 385篇 |
免费 | 15篇 |
国内免费 | 7篇 |
专业分类
儿科学 | 9篇 |
妇产科学 | 5篇 |
基础医学 | 70篇 |
口腔科学 | 1篇 |
临床医学 | 13篇 |
内科学 | 153篇 |
皮肤病学 | 7篇 |
神经病学 | 11篇 |
特种医学 | 2篇 |
外科学 | 38篇 |
综合类 | 1篇 |
预防医学 | 5篇 |
药学 | 45篇 |
肿瘤学 | 47篇 |
出版年
2023年 | 2篇 |
2022年 | 5篇 |
2021年 | 5篇 |
2020年 | 8篇 |
2019年 | 15篇 |
2018年 | 15篇 |
2017年 | 10篇 |
2016年 | 11篇 |
2015年 | 6篇 |
2014年 | 10篇 |
2013年 | 11篇 |
2012年 | 20篇 |
2011年 | 20篇 |
2010年 | 18篇 |
2009年 | 13篇 |
2008年 | 28篇 |
2007年 | 20篇 |
2006年 | 20篇 |
2005年 | 20篇 |
2004年 | 27篇 |
2003年 | 19篇 |
2002年 | 23篇 |
2001年 | 5篇 |
2000年 | 8篇 |
1999年 | 11篇 |
1998年 | 3篇 |
1997年 | 6篇 |
1996年 | 2篇 |
1995年 | 4篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1978年 | 1篇 |
排序方式: 共有407条查询结果,搜索用时 15 毫秒
41.
Predictive Histopathologic Factors for Lymph Node Metastasis in Patients With Nonpedunculated Submucosal Invasive Colorectal Carcinoma 总被引:4,自引:3,他引:4
Tominaga K Nakanishi Y Nimura S Yoshimura K Sakai Y Shimoda T 《Diseases of the colon and rectum》2005,48(1):92-100
PURPOSE Risk factors for lymph node metastasis in patients with nonpedunculated submucosal invasive colorectal carcinoma remain to be characterized. This study examines the relationship between lymph node metastasis and clinicopathologic factors in nonpedunculated submucosal invasive colorectal carcinoma.METHODS The study cohort comprised 155 patients who had undergone surgical treatment for nonpedunculated submucosal invasive colorectal carcinoma. The clinicopathologic factors investigated included gender, age, tumor location, macroscopic type, tumor size, histologic type and grade, intramucosal growth pattern, lymphatic invasion, venous invasion, degree of focal dedifferentiation at the submucosal invasive front, status of the remaining muscularis mucosa, and the depth and width of submucosal invasion.RESULTS Lymph node metastases were found in 19 patients (12.3 percent). Univariate analysis showed that lymphatic invasion, focal dedifferentiation at the submucosal invasive front, status of the remaining muscularis mucosa, and depth of submucosal invasion all had a significant influence on lymph node metastasis. Multivariate analysis showed lymphatic invasion (P = 0.014) and high-grade focal dedifferentiation at the submucosal invasive front (P = 0.049) to be independent factors predicting lymph node metastasis. No lymph node metastasis was found in tumors with a depth of submucosal invasion of <1.3 mm.CONCLUSIONS Lymphatic invasion and high-grade focal dedifferentiation at the submucosal invasive front are important predictors of lymph node metastasis in patients with nonpedunculated submucosal invasive colorectal carcinoma. Depth of submucosal invasion can be used as an identifying marker for patients who do not require subsequent surgery after endoscopic resection.Supported in part by a grant-in-aid for cancer research from the Ministry of Health and Welfare of Japan. 相似文献
42.
Takashi Matsushiro Takafumi Sato Akiko Umezawa Hiromi Tokumura Youichi Imaoka Akio Ouchi Kyoji Yamamoto Haruo Ohtani 《Journal of hepato-biliary-pancreatic sciences》1997,4(1):91-94
The objective of this study was to clarify the etiology of acute cholecystitis and the role of bacteria in the bile in this condition. We evaluated 52 patients with acute cholecystitis; 46 had cholesterol stones and 6 had no claculi. In the presence of cystic duct obstruction, circulatory disturbance occurs gradually, but circulatory disturbance alone cannot cause severe inflammation unless a bacterial infection is present. If there is no obstruction, rapid circulatory disturbance produces necrotic changes of the gallbladder wall, which are implicated in a fulminant course. In both instances, bacterial infection may play an important role in fulminant cholecystitis. Bacteria implicated in acute cholecystitis are usually present in the bile before the onset of this disease. 相似文献
43.
44.
45.
Itoh T Abe K Tokumura M Hirono S Haruna M Ibii N 《Clinical and experimental hypertension (New York, N.Y. : 1993)》2004,26(6):485-498
We investigated the difference in mechanical function after ischemia and reperfusion between Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) or stroke-prone SHR (SHRSP) using the isolated working heart model, in order to examine postischemic mechanical dysfunction in the severely hypertrophied heart. Systolic blood pressure of SHRSP was higher than that of SHR and WKY, and the left ventricular wall in SHRSP was thicker than in WKY. Mechanical dysfunction of the heart during reperfusion following ischemia (11 min) in SHRSP was severer than that in SHR and WKY, and recovery of the cardiac energy charge potential (ECP) level in SHRSP was lower than that in SHR and WKY. Twenty-five, 12 and 11 min-ischemia in WKY, SHR and SHRSP, respectively, caused a similar level of cardiac mechanical damage. Also, the ECP levels were almost equivalent among them at the end of 20 min reperfusion following each time of ischemia. Under each ischemic condition, a Ca2+-channel blocker, diltiazem, and an adenosine potentiator, dilazep, produced a beneficial effect on the post-ischemic dysfunction in SHR and WKY. However, neither cardioprotective drug led to recovery of the mechanical dysfunction of the heart during reperfusion following ischemia in SHRSP. Thus, the severely hypertrophied heart such as that in SHRSP was more susceptible to cardiac reperfusion dysfunction, than the moderately hypertrophied heart such as that in SHR. These results suggest that the cardioprotective effects of drugs may be deteriorated in severe hypertrophied hearts. 相似文献
46.
Yoshiaki Hamamoto Shinji Harada Naoki Yamamoto Yahiro Uemura Takashi Goto and Tadakazu Suyama 《Vox sanguinis》1987,53(2):65-69
More than 10(4) plaque-forming units (pfu)/ml of HIV are inactivated during the alcohol fractionation step from plasma to fraction (Fr)-II+III, greater than 10(4) pfu/ml is inactivated from Fr-II+III to Fr-II and greater than 10(4) pfu/ml is inactivated during the polyethylene glycol (PEG) fractionation process from Fr-II+III to intravenous IgG (IVIG). The total inactivation rate from plasma to IVIG via Fr-II+III or Fr-II was calculated to be greater than 10(8) or 10(12), respectively. The PEG fractionation method produces an intact and unmodified IVIG. In addition, the PEG fractionation method at a low ionic strength was found to be effective for the elimination of greater than 10(5) units of other viruses, including hepatitis B, vesicular stomatitis and Sindbis viruses. 相似文献
47.
Tsukamoto S Fujita S Yamaguchi T Yamamoto S Akasu T Moriya Y Taniguchi H Shimoda T 《International journal of colorectal disease》2008,23(11):1109-1113
Background To clarify the oncological outcome of rectal well-differentiated neuroendocrine tumors (W/D NETs), we examined the clinicopathological
characteristics and prognosis of patients with this neoplasm.
Materials and methods A total of 23 patients who underwent surgical treatment with lymph node dissection for rectal W/D NETs between 1973 and 2007
were reviewed.
Results Median tumor size measured preoperatively was 13 mm (range, 4–25 mm), and the median number of dissected lymph nodes was 16
(range, 1–46). The incidence of lymph node metastasis was 61% (14 of 23 cases). The smallest W/D NETs with lymph node metastasis
was 10 mm in diameter. All the patients without lymph node metastasis survived without recurrence. Among 11 patients who had
only regional lymph node metastasis, only one developed liver metastasis and died 13 months after initial surgery. Among three
patients with lateral pelvic lymph node metastasis, two survived more than 5 years, although two had liver metastasis.
Conclusions Because the incidence of lymph node metastasis is very high in patients with rectal W/D NETs greater than 10 mm in diameter,
radical surgery is required. In this series, the outcome of rectal W/D NETs patients with lateral pelvic lymph node metastasis
was better than expected. 相似文献
48.
Mitsuru Itoh Toshiyuki Kitano Mitsumasa Watanabe Tadakazu Kondo Takeshi Yabu Yoshimitu Taguchi Kazuya Iwai Masaro Tashima Takashi Uchiyama Toshiro Okazaki 《Clinical cancer research》2003,9(1):415-423
We investigated the possibility of the proapoptotic lipid ceramide as an indicator of chemoresistance in leukemia. Doxorubicin (DOX) increased the ceramide level and apoptosis in drug-sensitive HL-60 cells but not in drug-resistant HL-60/ADR cells, under the condition that the uptake of DOX was not different between the two cell lines. In addition, exogenous N-acetylsphingosine (C2-ceramide) enhanced DOX-induced apoptosis in HL-60/ADR cells without affecting the expression of multidrug resistant-1 protein (MDR 1) and the uptake of DOX. A lower level of ceramide with higher activities of glucosylceramide synthase (GCS) and sphingomyelin synthase (SMS) was detected in HL-60/ADR cells than in HL-60 cells. In contrast, HL-60/GCS cells, overexpressing GCS, significantly inhibited DOX-induced ceramide increase and apoptosis. These observations suggest the involvement of ceramide regulation in drug resistance of leukemia cells. In vivo, the level of ceramide was lower in chemoresistant leukemia patients (6.4 +/- 1.8 pmol/nmol phosphate; n = 14) than in chemosensitive patients (9.5 +/- 2.7 pmol/nmol phosphate; n = 9), and the activities of GCS and SMS were more than 2-fold higher in chemoresistant leukemia cells than in chemosensitive cells. MDR-1 protein was faintly expressed in one of four chemoresistant patients, but Bcl-2 were clearly detected in four patients. Therefore, it is suggested that a decrease of the ceramide level via activation of GCS and SMS is associated with the chemoresistant condition in leukemia, probably in relation to Bcl-2 but not to MDR-1 expression. 相似文献
49.
Hiroyuki Takamatsu Takeshi Yamashita Shingo Kurahashi Takayuki Saitoh Tadakazu Kondo Takeshi Maeda Hideyuki Nakazawa Makoto Murata Tomoko Narita Junya Kuroda Hisako Hashimoto Koji Kawamura Toshihiro Miyamoto Sumihisa Honda Tatsuo Ichinohe Yoshiko Atsuta Kazutaka Sunami 《Biology of blood and marrow transplantation》2019,25(3):474-479
Conventional cytogenetic analyses and fluorescent in situ hybridization (FISH) are helpful for stratifying patients with multiple myeloma (MM) into high-risk [t(4;14), t(14;16), and/or del 17p] and standard-risk [t(11;14)] categories. However, the prognosis of patients with MM treated with autologous stem cell transplantation (ASCT) stratified according to these categories remains unclear. This retrospective observational study analyzed 97 patients with MM who received a single, planned ASCT after treatment with 200 mg/m2 melphalan between 2001 and 2011. The patients were grouped according to chromosomal abnormality, including t(11;14) (n?=?45), t(4;14) (n?=?31), del 17p (n?=?10), t(11;14) with del 17p (n?=?7), and t(4;14) with del 17p (n?=?4). Median overall survival (OS) of the t(11;14) group (64.1 months) was not significantly different from that of the t(4;14) group (not reached), but it was significantly longer than that of the del 17p group (23.0 months; P?=?.002). G-banding revealed that the median OS of the t(11;14) group with additional chromosomal abnormalities (ACAs) (46.2 months) was significantly shorter than that of the t(11;14) group without ACAs (not reached; P?=?.005) and the t(4;14) group (not reached; P?=?.010). These findings highlight the importance of G-banding in patients with t(11;14) MM. 相似文献
50.