全文获取类型
收费全文 | 608篇 |
免费 | 45篇 |
国内免费 | 8篇 |
专业分类
儿科学 | 51篇 |
妇产科学 | 3篇 |
基础医学 | 66篇 |
口腔科学 | 11篇 |
临床医学 | 124篇 |
内科学 | 137篇 |
皮肤病学 | 2篇 |
神经病学 | 8篇 |
特种医学 | 136篇 |
外科学 | 26篇 |
综合类 | 11篇 |
预防医学 | 21篇 |
眼科学 | 5篇 |
药学 | 28篇 |
中国医学 | 2篇 |
肿瘤学 | 30篇 |
出版年
2020年 | 6篇 |
2018年 | 3篇 |
2016年 | 3篇 |
2015年 | 6篇 |
2014年 | 7篇 |
2013年 | 12篇 |
2012年 | 6篇 |
2011年 | 8篇 |
2010年 | 11篇 |
2009年 | 14篇 |
2008年 | 6篇 |
2007年 | 7篇 |
2006年 | 12篇 |
2005年 | 12篇 |
2004年 | 6篇 |
2003年 | 9篇 |
2002年 | 11篇 |
2001年 | 11篇 |
2000年 | 8篇 |
1999年 | 11篇 |
1998年 | 38篇 |
1997年 | 61篇 |
1996年 | 40篇 |
1995年 | 34篇 |
1994年 | 37篇 |
1993年 | 27篇 |
1992年 | 20篇 |
1991年 | 13篇 |
1990年 | 7篇 |
1989年 | 17篇 |
1988年 | 21篇 |
1987年 | 18篇 |
1986年 | 20篇 |
1985年 | 20篇 |
1984年 | 14篇 |
1983年 | 6篇 |
1982年 | 11篇 |
1981年 | 7篇 |
1980年 | 9篇 |
1978年 | 9篇 |
1977年 | 13篇 |
1976年 | 5篇 |
1975年 | 10篇 |
1973年 | 6篇 |
1970年 | 3篇 |
1967年 | 2篇 |
1966年 | 2篇 |
1965年 | 3篇 |
1963年 | 2篇 |
1961年 | 2篇 |
排序方式: 共有661条查询结果,搜索用时 15 毫秒
101.
INTRODUCTION
The management of Hirschsprung’s disease continues to evolve. This questionnaire survey aimed to determine current surgical management strategies for Hirschsprung’s disease in Britain.SUBJECTS AND METHODS
The survey was sent electronically to all British paediatric surgeons. Initial questions explored individual experience and regional service provision. Additional questions, reserved for surgeons who perform definitive Hirschsprung’s disease surgery, addressed specific clinical scenarios.RESULTS
Surveys were sent to 142 surgeons yielding 85 responses. After exclusions, 64 surveys from 21 centres were analysed. Forty-seven respondents worked in centres with designated ‘Hirschsprung’s disease surgeons’. Forty respondents perform definitive Hirschsprung’s disease surgery. In a well neonate with left-sided Hirschsprung’s disease, 34 of 40 surgeons favour primary pull-through following bowel decompression with rectal washouts; 35 of 40 surgeons aim to perform definitive surgery at less than 3 months of age, with 17 favouring laparoscopic-assisted Soave–Boley and 15 favouring an open Duhamel pull-through. Of the 40 surgeons, 36 use a staged approach to right-sided/total colonic Hirschsprung’s disease with 23 favouring a Duhamel or Long Duhamel pull-through.CONCLUSIONS
The primary pull-through, using an open Duhamel or laparoscopic-assisted Soave–Boley technique, during the first 3 months of life, has become the operative strategy of choice in rectosigmoid Hirschsprung’s disease in Britain. Marked variation in practice remains for right-sided Hirschsprung’s disease. 相似文献102.
The how and why of exocytic vesicles 总被引:1,自引:0,他引:1
Greenwalt TJ 《Transfusion》2006,46(1):143-152
The purpose of this review is to draw the attention of general readers to the importance of cellular exocytic vesiculation as a normal mechanism of development and subsequent adjustment to changing conditions, focusing on red cell (RBC) vesiculation. Recent studies have emphasized the possible role of these microparticles as diagnostic and investigative tools. RBCs lose membrane, both in vivo and during ex vivo storage, by the blebbing of microvesicles from the tips of echinocytic spicules. Microvesicles shed by RBCs in vivo are rapidly removed by the reticuloendothelial system. During storage, this loss of membrane contributes to the storage lesion and the accumulation of the microvesicles are believed to be thrombogenic and thus to be clinically important. 相似文献
103.
Sixty years ago, the premier blood grouping laboratory was that of Robert Race in London. Agglutination tests and blood grouping had provided breakthroughs in immunology, genetics, and the solution of clinical problems. The significance of immunohematology was recognized by the clinical hematology community as a potent force in the expanding field of disorders of the blood and blood-forming organs. The instructions by Race to his London workers entitled Hints to Blood Groupers provide a picture of the immunohematology laboratory even before automation and differed slightly from the American techniques that derived from Landsteiner. Before agglutination is replaced in the near future by the emergence of molecular methods, the detailed method of a superb laboratory is recorded. 相似文献
104.
105.
Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias 总被引:9,自引:0,他引:9
Wollnik B; Schroeder BC; Kubisch C; Esperer HD; Wieacker P; Jentsch TJ 《Human molecular genetics》1997,6(11):1943-1949
The inherited long QT syndrome (LQTS), characterized by a prolonged QT
interval in the electrocardiogram and cardiac arrhythmia, is caused by
mutations in at least four different genes, three of which have been
identified and encode cardiac ion channels. The most common form of LQTS is
due to mutations in the potassium channel gene KVLQT1, but their effects on
associated currents are still unknown. Different mutations in KVLQT1 cause
the dominant Romano-Ward (RW) syndrome and the recessive Jervell and
Lange-Nielsen (JLN) syndrome, which, in addition to cardiac abnormalities,
includes congenital deafness. Co- expression of KvLQT1 with the IsK protein
elicits slowly activating potassium currents resembling the cardiac Iks
current. We now show that IsK not only changes the kinetics of KvLQT1
currents, but also its ion selectivity. Several mutations found in RW,
including a novel mutation (D222N) in the putative channel pore, abolish
channel activity and reduce the activity of wild-type KvLQT1 by a
dominant-negative mechanism. By contrast, a JLN mutation truncating the
carboxyterminus of the KvLQT1 channel protein abolishes channel function
without having a dominant-negative effect. This fully explains the
different patterns of inheritance. Further, we identified a novel splice
variant of the KVLQT1 gene, but could not achieve functional expression of
this nor of a previously described heart-specific isoform.
相似文献
106.
107.
低聚果糖口服补液盐的试制 总被引:8,自引:0,他引:8
目的:改良口服补液盐(ORS),使其具有微生态调节作用、并与肠道内渗透压相似。方法:将氯化钠2.6g、氯化钾1.5g、枸橼酸钠2.9g、低聚果糖(FOS)20g和葡萄糖10g等混合后低聚果糖口服液盐(FOS-ORS)。密封包装,使用时加开水1000ml冲服。可采用高效液相色谱法测定FOS的含量。结果:FOS-ORS为白色散剂,加水后为无色透明液体,味甜中微咸,其浓度(mmol/L)为钠75、钾20 相似文献
108.
M. Louise Markert Bruce D. Finkel Tanya M. McLaughlin TJ Watson Harold R. Collard Connette P. McMahon Lucy G. Andrews Michael J. Barrett Frances E. Ward 《Human mutation》1997,9(2):118-121
Purine nucleoside phosphorylase deficiency is an inherited disease of purine metabolism characterized clinically as combined immunodeficiency. The molecular defects have been published for 4 different alleles in 3 patients. We report four new mutations including two amino acid substitutions, A 174P and G190V, a single codon deletion, ΔI129, and a point mutation in intron 3 which leads to aberrant splicing and creation of a premature stop codon in exon 4 (286 -18G→A). Of the previously reported mutations, E89K was found in one additional patient, and R234P was found in 3 unrelated patients, making R234P the most common mutation reported to date in this disease. Hum Mutat 9:118–121, 1997. © 1997 Wiley-Liss, Inc. 相似文献
109.
110.
Daniels DL; Czervionke LF; Millen SJ; Haberkamp TJ; Meyer GA; Hendrix LE; Mark LP; Williams AL; Haughton VM 《Radiology》1989,171(3):807-809
The authors evaluated magnetic resonance (MR) images obtained with intravenously administered gadolinium in ten patients who had facial paralysis and no facial nerve tumor. In patients with either Bell palsy (four patients) or facial paralysis after temporal bone surgery (six patients), intratemporal facial nerve enhancement was seen. Facial nerve enhancement on MR images proved to be a nonspecific finding. 相似文献