原癌基因C－erb B－2蛋白产物在前列腺癌中的表达

应用抗Ｃ－ｅｒｂＢ－２癌蛋白抗体对３０例前列腺癌进行研究，同时选取１０例正常前列腺组织作为对照。结果表明Ｃ－ｅｒｂＢ－２蛋白与肿瘤分化程度有关。并可能对判断其生物学行为，评估预后有重要意义。     

The postoperative recurrence of crohn's disease: An analysis of 37 patients with crohn's disease who underwent endoscopy during initial surgery

A total 37 patients with Crohn's disease who underwent intraoperative endoscopy during resection of the affected intestine were evaluated in this study. The average age of the patients at surgery was 23.2 years. The residual lesions in the remaining intestine identified by intraoperative endoscopy were classified according to their pathologic profiles into three groups: A, B and C. In group A, comprising patients with longitudinal ulcers and/or a cobblestone appearance, 10 of 12 patients had recurrence. In 5 of these 10, the residual lesions were exacerbated and 2 required a further operation. The remaining 5 patients showed recurrence at the site of previous anastomosis and 2 of these 5 required additional surgery.In group B, comprising patients with small ulcers, aphthoid ulcers, or scars, and group C, comprising patients with no residual lesions, recurrence was observed in 13 of 16, and 3 of 9 patients, respectively. The recurrent lesions were all found proximal to, or at the site of previous anastomosis. Additional operations were performed on 3 of the group B patients. The findings of this study revealed that recurrence requiring additional surgery is more frequent at the site of anastomosis, regardless of the endoscopic appearance of the residual lesions.     

Correlation between Cyclin A Gene Expression in Adult Patients with Acute Leukemia and Drug Resistance

Adultacuteleukemia (AL)isoneofthemostcommonmalignanttumorsofhematology .Withtherecentprogressinchemotherapyandsupportivether apy ,theremissionandsurvivalrateinALhavebeenmarkedlyimproved .However ,drugresistanceandrelapsearestillimportantfactorsaffectinglongsur vivalofthese patients .Theabnormalregulationofcellcycleisanotherfactorthatcannotbeignoredex ceptformultipledrugresistance (MDR) .WedetectcyclinA ,multidrugresistantgene (mdrl) ,topoiso meraseⅡα(TopⅡα)andbcl 2inadultpatientswithA…     

第一掌背动脉双叶皮瓣在手外科中的应用

我们设计主要以第1掌背动脉为蒂的手背双叶皮瓣,同时修复两个部位的手部皮肤缺损和拇指再造,共10例均获成功。皮瓣面积最小10cm×3cm,最大13cm×5cm,蒂宽1.5cm×2.5cm。皮瓣每叶面积最小为3.5cm×2cm,最大6cm×3cm。文中介绍了本皮瓣的解剖学基础,并对其手术适应证和优缺点进行了讨论。     

老年2型糖尿病患者胰岛素抵抗相关指标的检测和意义

目的:探讨老年2型糖尿病胰岛素抵抗(IR)及其相关性,为老年2型糖尿病的合理防治提供临床依据。方法:选择120例老年2型糖尿病患者,按胰岛素敏感指数(HOMA)胰岛素抵抗(HOMA-IR)50百分位点将患者分为两组:胰岛素相对敏感组(HOMA-IR<3.56)和胰岛素相对抵抗组(HOMA-IR≥3.56),比较体重指数(BMI)、腰/臀比(WHR)、血压、血生化学检查等指标。用年龄>40岁,<60岁的2型糖尿病患者做对照组。结果:两组老年患者在年龄、性别、舒张压、空腹血糖、胆固醇、高密度脂蛋白、糖化血红蛋白、HOMA胰岛β细胞功能方面无差异;但BMI、WHR、收缩压、甘油三脂、空腹胰岛素、HOMA-IR差异具有显著性。多线性回归分析后,只有腰/臀比、收缩压、甘油三脂、HOMA-IR存在统计学差异。老年患者与对照组相比,IR发生率明显增加,且两者腰/臀比、收缩压、甘油三脂方面也差异显著。结论:IR与老年2型糖尿病密切相关,是临床防治糖尿病的重要靶点。     

103例流行性出血热患者的心电图及心肌酶学分析

目的了解流行性出血热病毒(EHFV)对心脏的损害情况。方法对103例流行性出血热(EHF)患者的心电图及心肌酶学检测结果进行分析。结果72例(69.9%)患者出现心电图异常,以窦性心动过缓(27.9%)及窦性心动过速(22.3%)最常见,明显高于其它类型的心电图改变(P分别<0.05和0.001)。103例流行性出血热(EHF)患者的CK、LDH及HBDH的升高者分别为43例(41.2%)、73例(70.9%)及46例(44.7%),以LDH异常最常见。轻型、中型、重型及危重型流行性出血热患者的LDH值分别为(346.3±155.6)IU/L、(330.7±130.7)IU/L、(1114.4±872.4)IU/L及(1227.1±936.7)IU/L,经统计学处理重型及危重型的值与轻型、中型比较均有显著性或高度显者性差异。结论EHF患者并发心肌损害较普遍,而且病情愈重者,心肌损害愈严重。     

磁场对家兔急性实验性高血压的影响

目的 :探讨内关穴敷磁的降压效应。方法 :40只清醒家兔和 40只麻醉家兔 (其中 2 0只去减压神经 ) ,静脉注射去甲肾上腺素或苯肾上腺素引起急性实验性高血压 ,并于内关穴敷磁 (0 .1～ 0 .2T) ,记录血压、心率和敷磁前及 1h后的血液粘度的变化。结果 :敷磁 1h后各实验组平均动脉压 (MAP)显著下降 (P <0 .0 1)。麻醉和清醒家兔MAP降幅无差异 (P >0 .0 5 ) ,但显著高于去减压神经家兔MAP的降幅 (P <0 .0 1或 0 .0 5 ) ,各实验组全血比粘度显著下降 (P <0 .0 1或 0 .0 5 ) ,实验组与各自对照组心率敷磁前后无差异 (P >0 .0 5 )。结论 :磁场具有降压作用 ,但对心率无影响 ,其降压效应与减压神经的抑制和全血粘度的降低有关 ,与化学感受性升压反射无关     

HQJ-500多功能净水装置装舰试用评价

目的：改善舰船官兵的饮用水水质，提高舰员的生活质量。方法：将研制的HQJ-500多功能净水装置装舰试用，征求试用意见并进行水质分析。结果：经实船试用证实，该多功能净水器能经受住各种海况下颠簸，摇晃的考验。运行正常。处理后的水质有明显改善。结论：该装置净化，消毒效果肯定，适合舰船使用，可推广应用。     

益肾化浊注射液对慢性肾功能衰竭大鼠残余肾中细胞因子含量的影响

通过观察益肾化浊注射液对5／6肾切除大鼠残余肾中细胞因子含量的影响，益肾化浊注射液延缓慢性肾功能衰竭（CRF）模型大鼠肾功能减退的作用机理。结果显示：益肾化浊注射液可以降低5／6肾切在鼠血清肌,尿素氮（P＜0．01），下调肾组织中白细胞介素－1（IL－1）（P＜0．05），白细胞介素－8（IL－8）（P＜0．05）及肿瘤坏死因子（TNF）（P＜0．05）的总体水平，说明益肾化浊注射液可以通过下调5／6肾切除大鼠残余肾中相关细胞因子含量，抑制促炎细胞因子对肾脏的损害，从而延缓CRF的进展。