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排序方式: 共有524条查询结果,搜索用时 15 毫秒
521.
D H Szolar R Groell K Preidler H Braun M A Stiskal H Stammberger W P Dillon 《AJNR. American journal of neuroradiology》1995,16(9):1889
PURPOSETo evaluate the diagnostic potential of three-dimensional image processing of ultrafast CT sialography in comparison with conventional CT sialography in patients with parotid masses.METHODSIn nine patients, CT sialography was done with three-dimensional image processing. The visibility of anatomic details and pathologic findings, derived from three-dimensional images, were graded numerically by three observers and compared with the findings obtained from conventional CT sialograms. Histopathologic specimens were obtained in all cases.RESULTSUltrafast CT images showed no motion artifact. Three-dimensional CT sialography offered significant improvement in demonstration of ductal anatomy (2.5 +/- 0.2 versus 1.5 +/- 0.1, respectively) and ductal pathology (2.6 +/- 0.1 versus 1.1 +/- 0.2, respectively) over conventional CT sialography. In two cases, the therapeutic regimen was altered substantially.CONCLUSIONUltrafast CT three-dimensional sialography has the potential to allow more precise presurgical planning and contributes to the diagnosis and therapy planning of parotid masses, especially in patients in whom MR image quality is degraded by motion artifact. 相似文献
522.
苦参碱对脂多糖/痤疮丙酸杆菌诱导的小鼠肝炎及产生肿瘤坏死因子的影响 总被引:4,自引:0,他引:4
用小鼠致死性肝炎模型和TNF体外诱生的方法,研究苦参碱(Mat)对脂多糖(lipopolysaccharides,LPS)诱导的经痤疮丙酸杆菌(propionibacterittmacnes,PA)预刺激的小鼠产生肿瘤坏死因子(TNF)以及致死性肝炎的影响。结果表明:Mat(10,50mg·kg ̄(-1),ip,bid×3d)可降低血清TNF和ALT水平及小鼠对LPS致死毒性的敏感性,并可在体外抑制LPS诱导的经PA预刺激的小鼠腹腔巨噬细胞释放TNF。提示Mat的保肝作用与其抑制TNF释放有关。 相似文献
523.
524.
Linkage and physical mapping of X-linked lissencephaly/SBH (XLIS): a gene causing neuronal migration defects in human brain 总被引:6,自引:2,他引:6
Ross ME; Allen KM; Srivastava AK; Featherstone T; Gleeson JG; Hirsch B; Harding BN; Andermann E; Abdullah R; Berg M; Czapansky-Bielman D; Flanders DJ; Guerrini R; Motte J; Mira AP; Scheffer I; Berkovic S; Scaravilli F; King RA; Ledbetter DH; Schlessinger D; Dobyns WB; Walsh CA 《Human molecular genetics》1997,6(4):555-562
While disorders of neuronal migration are associated with as much as 25% of
recurrent childhood seizures, few of the genes required to establish
neuronal position in cerebral cortex are known. Subcortical band
heterotopia (SBH) and lissencephaly (LIS), two distinct neuronal migration
disorders producing epilepsy and variable cognitive impairment, can be
inherited alone or together in a single pedigree. Here we report a new
genetic locus, XLIS, mapped by linkage analysis of five families and
physical mapping of a balanced X;2 translocation in a girl with LIS.
Linkage places the critical region in Xq21-q24, containing the breakpoint
that maps to Xq22.3-q23 by high-resolution chromosome analysis. Markers
used for somatic cell hybrid and fluorescence in situ hybridization
analyses place the XLIS region within a 1 cM interval. These data suggest
that SBH and X-linked lissencephaly are caused by mutation of a single
gene, XLIS, that the milder SBH phenotype in females results from random
X-inactivation (Lyonization), and that cloning of genes from the breakpoint
region on X will yield XLIS.
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