弱视的双眼视功能重建

目的：评价不同年龄、不同类型弱视的双眼视功能的训练效果。方法：观察各年龄组不同类型弱视62例94例,给予综合治疗及双眼视功能训练。治疗前及治疗后分别用同视机和《Randot Sterrotesis》图谱检查融合范围和立体视锐度。结果：随访12～30个月,视力进步82眼（占87.2%）,融合范围扩大39例（占62.9%）,立体视锐度提高37例（占59.7%）,双眼视功能训练的效果,各年龄组之间差异无显著性意义,但不同类型弱视之间差异有显著性意义,屈光不正性弱视疗效最好,形觉剥夺性弱视疗效最差。结论：不同年龄、不同类型的弱视患者经过综合治疗和双眼视功能训练后,大多有不同程度的视力进步,融合范围扩大及立体视锐度的提高。     

Gute Compliance mit Buccaltablette

panorama

Thromboserezidiv-prophylaxe mit Dalteparin     

In vivo imaging of T cell delivery to tumors after adoptive transfer therapy

Adoptive transfer therapy of in vitro-expanded tumor-specific cytolytic T lymphocytes (CTLs) can mediate objective cancer regression in patients. Yet, technical limitations hamper precise monitoring of posttherapy T cell responses. Here we show in a mouse model that fused single photon emission computed tomography and x-ray computed tomography allows quantitative whole-body imaging of (111)In-oxine-labeled CTLs at tumor sites. Assessment of CTL localization is rapid, noninvasive, three-dimensional, and can be repeated for longitudinal analyses. We compared the effects of lymphodepletion before adoptive transfer on CTL recruitment and report that combined treatment increased intratumoral delivery of CTLs and improved antitumor efficacy. Because (111)In-oxine is a Food and Drug Administration-approved clinical agent, and human SPECT-CT systems are available, this approach should be clinically translatable, insofar as it may assess the efficacy of immunization procedures in individual patients and lead to development of more effective therapies.     

From the Cover: Rapid detection and profiling of cancer cells in fine-needle aspirates

There is a growing need for fast, highly sensitive and quantitative technologies to detect and profile unaltered cells in biological samples. Technologies in current clinical use are often time consuming, expensive, or require considerable sample sizes. Here, we report a diagnostic magnetic resonance (DMR) sensor that combines a miniaturized NMR probe with targeted magnetic nanoparticles for detection and molecular profiling of cancer cells. The sensor measures the transverse relaxation rate of water molecules in biological samples in which target cells of interest are labeled with magnetic nanoparticles. We achieved remarkable sensitivity improvements over our prior DMR prototypes by synthesizing new nanoparticles with higher transverse relaxivity and by optimizing assay protocols. We detected as few as 2 cancer cells in 1-μL sample volumes of unprocessed fine-needle aspirates of tumors and profiled the expression of several cellular markers in <15 min.     

Zur Frage über die Retention des festen Mageninhaltes beim hungernden Kaninchen

Ohne Zusammenfassung     

天津市“九五”期间低视力康复调研报告

目的：总结“九五”期间低视力康复工作的经验,找出差距,为“十五”期间制订一整套有效的康复网络及措施提供参考。方法：按要求逐项登记接诊的低视力患者,进行眼科常规检查后,给予远、近助视器及闭路电视（CCTV）进行康复训练。结果：低视力患者的主要来源是：天津市管辖区内占84.1%,外省市占15.1%,国际友人占0.7%。主要病因：儿童仍是先天性/遗传性眼病,而成人患者特别是老年人则是高度近视、糖尿病性眼底病变及老年性白内障,接受应用助视器的人数不多,不到总人数的30%,但近2年来CCTV深受欢迎,接诊登记患者的人数近1～2年来有明显下降的趋势。结论：深入开展低视力康复工作和应用助视器对低视力患者的恢复有很大帮助。     

雷公藤红素抑制抗体形成及抗炎作用

雷公藤红素是雷公藤主妻活性成分之一,本支报道它在试管内及整体均明显抑制小鼠脾细胞溶血空斑细胞的形成,此作用与浓度呈依赖关系。对手大鼠实验性棉球肉芽肿的形成,小鼠二硝基氧苯。(DNCB)所致迟发型超敏反应均有明显抑制作用,回时还观察到它能延长戊巴比妥钠致小鼠睡眠时间。     

对中医学"心主神明"和"脑主神明"的再认识

在回顾《黄帝内经》及历代医家关于心、脑功能的论述的基础上,提出变革“心主神明”说,确立“脑主神明”论的观点。指出：传统中医学虽以“心主神明”立论,但对脑与精神、感觉、知觉及生命健康的关系也有描述,与“脑主神明”的认识相按近;并从系统修正、审慎扬弃、理论建设、方法研究等四个方面分析,强调确立“脑主神明”论符合中医药学自身发展规律。