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131.
Jose U. Scher Carles Ubeda Michele Equinda Raya Khanin Yvonne Buischi Agnes Viale Lauren Lipuma Mukundan Attur Michael H. Pillinger Gerald Weissmann Dan R. Littman Eric G. Pamer Walter A. Bretz Steven B. Abramson 《Arthritis \u0026amp; Rheumatology》2012,64(10):3083-3094
Objective
To profile the abundance and diversity of subgingival oral microbiota in patients with never‐treated, new‐onset rheumatoid arthritis (RA).Methods
Periodontal disease (PD) status, clinical activity, and sociodemographic factors were determined in patients with new‐onset RA, patients with chronic RA, and healthy subjects. Multiplexed‐454 pyrosequencing was used to compare the composition of subgingival microbiota and establish correlations between the presence/abundance of bacteria and disease phenotypes. Anti–Porphyromonas gingivalis antibody testing was performed to assess prior exposure to the bacterial pathogen P gingivalis.Results
The more advanced forms of periodontitis were already present at disease onset in patients with new‐onset RA. The subgingival microbiota observed in patients with new‐onset RA was distinct from that found in healthy controls. In most cases, however, these microbial differences could be attributed to the severity of PD and were not inherent to RA. The presence and abundance of P gingivalis were also directly associated with the severity of PD and were not unique to RA. The presence of P gingivalis was not correlated with anti–citrullinated protein antibody (ACPA) titers. Overall exposure to P gingivalis was similar between patients with new‐onset RA and controls, observed in 78% of patients and 83% of controls. The presence and abundance of Anaeroglobus geminatus correlated with the presence of ACPAs/rheumatoid factor. Prevotella and Leptotrichia species were the only characteristic taxa observed in patients with new‐onset RA irrespective of PD status.Conclusion
Patients with new‐onset RA exhibited a high prevalence of PD at disease onset, despite their young age and paucity of smoking history. The subgingival microbiota profile in patients with new‐onset RA was similar to that in patients with chronic RA and healthy subjects whose PD was of comparable severity. Although colonization with P gingivalis correlated with the severity of PD, overall exposure to P gingivalis was similar among the groups. The role of A geminatus and Prevotella/Leptotrichia species in this process merits further study.132.
Christina Chen Raymond Huang Ainsley MacLean Alona Muzikansky Srinivasan Mukundan Patrick Y. Wen Andrew D. Norden 《Journal of neuro-oncology》2013,115(2):267-276
Although bevacizumab represented an important advance in treatment of recurrent high-grade gliomas (HGG), responses occur in fewer than half of patients. There are no validated biomarkers for anti-angiogenic therapy that are available for routine clinical use. We assessed the prognostic values of imaging and molecular markers in this patient population. MRI scans from 191 patients with recurrent HGG obtained prior to initiating bevacizumab were reviewed for areas of enhancement, necrosis, T2/FLAIR abnormality, and ADC values. Serial MRI scans following the initiation of bevacizumab were evaluated for response and progression. Non-radiographic markers including EGFR and MGMT status were also assessed with respect to response and patient survival. 65 of 191 patients (34 %) showed complete or partial response at the time of their best response MRI and demonstrated longer progression free survival (PFS) and overall survival (OS) compared to the group without response (PFS: 6.9 vs 3.5 months, OS: 10.9 vs 6.1 months). Minimum ADC values within enhancing and non-enhancing regions were lower in responders compared to those of non-responders (1,099 vs 984 × 10?6 mm2/s, p = 0.006). Smaller enhancing area was associated with longer OS (HR = 1.99, p = 0.017). The ratio of T2/FLAIR to enhancing area was prognostic of OS for only the Grade III HGG subgroup (HR = 0.14, p = 0.004). Area of enhancing tumor at baseline can stratify survival in patients with recurrent HGG treated with bevacizumab. The extent of edema relative to enhancing area may have a prognostic role specific to Grade III HGG. 相似文献
133.
Li J Yang B Levons J Pinnamaneni S Raghavan K 《Journal of pharmaceutical sciences》2011,100(11):4907-4921
Vitamin E D-alpha-tocopheryl polyethylene glycol succinate (TPGS) and polyethylene glycol are common excipients used in both preclinical and commercial formulations. In this paper, the phase diagrams of TPGS and polyethylene glycol 400 (PEG 400) in the presence of either water or ethanol were constructed. The effect of water and ethanol on the cloud point temperature of TPGS-PEG 400 mixtures was investigated. In general, the cloud point temperature was reduced by the presence of either water or ethanol in the formulation. However, water was more effective in lowering the cloud point temperature than ethanol. Similarly, the phase diagram of TPGS-PEG 1450 was constructed. The cloud point temperature was observed to decrease with increasing TPGS concentration. It was found that TPGS and PEG 1450 could form a single phase when TPGS concentration was above 75%, based on differential scanning calorimetry, and FT-Raman analysis indicated that a vibration at 1330 cm(-1) disappeared in the melted single phase. In addition, a systematic melting point depression was observed for the mixtures of TPGS-PEG 1450. In the presence of Ibuprofen, a model compound, the cloud point temperature was also reduced. Finally, the extended Flory-Huggins theory for polymer solution was used to analyze the entropic and enthalpic contributions of water and ethanol to the free energy of mixing. 相似文献
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Rajeev Redkar Anant Bangar Varun Hathiramani Vinod Raj C. Swathi 《Indian pediatrics》2018,55(10):871-873
Objective
To study the diagnostic methods and treatment outcomes in children with Budd-Chiari syndrome.Methods
Case records of 25 patients with Budd-Chiari syndrome were evaluated retrospectively. These patients were investigated with imaging techniques and underwent balloon angioplasty or surgical management.Results
21 patients underwent balloon angioplasty, of which 17 had good medium- to long-term results, while only one out of four patients who underwent a portocaval shunt survived.Conclusion
The balloon angioplasty has satisfactory outcome in the treatment of acute Budd-Chiari syndrome. In failed cases, the surgical therapy may be attempted, but the outcomes do not appear rewarding.138.
Ganapathy Aparna Mishra Avshesh Soni Megha Rani Kumar Priyanka Sadagopan Mukunth Kanthi Anil Vittal Patric Irene Rosetta Pia George Sobha Sridharan Aparajit Thyagarajan T. C. Aswathy S. L. Vidya H. K. Chinnappa Swathi M. Nayanala Swetha Prakash Manasa B. Raghavendrachar Vijayashree G. Parulekar Minothi Gowda Vykuntaraju K. Nampoothiri Sheela Menon Ramshekhar N. Pachat Divya Udani Vrajesh Naik Neeta Kamate Mahesh Devi A. Radha Rama Mohammed Kunju P. A. Nair Mohandas Hegde Anaita Udwadia Kumar M. Pradeep Sundaram Soumya Tilak Preetha Puri Ratna D. Shah Krati Sheth Jayesh Hasan Qurratulain Sheth Frenny Agrawal Pooja Katragadda Shanmukh Veeramachaneni Vamsi Chandru Vijay Hariharan Ramesh Mannan Ashraf U. 《Journal of neurology》2019,266(8):1919-1926
Journal of Neurology - Neurological disorders are clinically heterogeneous group of disorders and are major causes of disability and death. Several of these disorders are caused due to genetic... 相似文献
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