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231.
Naiya T Biswas A Neogi R Datta S Misra AK Das SK Ray K Ray J 《Acta neurologica Scandinavica》2006,114(3):210-215
OBJECTIVES: Dystonia is a common movement disorder. The purpose of this study is to examine the relative distribution of the primary dystonia subtypes and identify mutation (s) in the DYT1 gene in Indian patients. MATERIALS AND METHODS: Primary dystonia patients (n = 178) and controls (n = 63), lacking any symptoms of the disease, were recruited for the study from eastern India. The nucleotide variants in the DYT1 gene were identified by carrying out polymerase chain reaction, single stranded conformation polymorphism, and DNA sequencing. RESULTS: Unlike other reports, pain and/or tremor was more common in our sporadic patients than in familial cases. Three reported and two novel changes were identified in this gene. The homozygous genotype (G,G) for a missense variant (c.646G > C; Asp216His) was significantly over-represented in the patients compared with controls (P < 0.05). However, the commonly reported 3 bp deletion (904-906delGAG) was not detected. CONCLUSION: Our results suggest that the DYT1 gene might have a limited role in causation of dystonia in the Indian population. 相似文献
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Dalbeth N McQueen FM Singh JA MacDonald PA Edwards NL Schumacher HR Simon LS Stamp LK Neogi T Gaffo AL Khanna PP Becker MA Taylor WJ 《The Journal of rheumatology》2011,38(7):1458-1461
Despite the recognition that tophus regression is an important outcome measure in clinical trials of chronic gout, there is no agreed upon method of tophus measurement. A number of methods have been used in clinical trials of chronic gout, from simple physical measurement techniques to more complex advanced imaging methods. This article summarizes methods of tophus measurement and discusses their properties. Physical measurement using Vernier calipers meets most aspects of the Outcome Measures in Rheumatology (OMERACT) filter. Rigorous testing of the complex methods, particularly with respect to reliability and sensitivity to change, is needed to determine the appropriate use of these methods. Further information is also required regarding which method of physical measurement is best for use in future clinical trials. The need to develop and test a patient-reported outcome measure of tophus burden is also highlighted. 相似文献
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Direskeneli H Aydin SZ Kermani TA Matteson EL Boers M Herlyn K Luqmani RA Neogi T Seo P Suppiah R Tomasson G Merkel PA 《The Journal of rheumatology》2011,38(7):1471-1479
Giant cell (GCA) and Takayasu's arteritis (TAK) are 2 forms of large-vessel vasculitis (LVV) that involve the aorta and its major branches. GCA has a predilection for the cranial branches, while TAK tends to affect the extracranial branches. Both disorders may also cause nonspecific constitutional symptoms. Although some clinical features are more common in one or the other disorder and the ages of initial presentation differ substantially, there is enough clinical and histopathologic overlap between these disorders that some investigators suggest GCA and TAK may be 2 processes within the spectrum of a single disease. There have been few randomized therapeutic trials completed in GCA, and none in TAK. The lack of therapeutic trials in LVV is only partially explained by the rarity of these diseases. It is likely that the lack of well validated outcome measures for LVV and uncertainties regarding trial design contribute to the paucity of trials for these diseases. An initiative to develop a core set of outcome measures for use in clinical trials of LVV was launched by the international OMERACT Vasculitis Working Group in 2009 and subsequently endorsed by the OMERACT community at the OMERACT 10 meeting. Aims of this initiative include: (1) to review the literature and existing data related to outcome assessments in LVV; (2) to obtain the opinion of experts and patients on disease content; and (3) to formulate a research agenda to facilitate a more data-based approach to outcomes development. 相似文献
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Narender Rohilla Sudeep Jain Sameer Naranje Devdatta S. Neogi C. S. Yadav Prakash P. Kotwal 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2009,19(4):269-271
We report a highly unusual case of post traumatic completely embedded ring through a 2 mm of wound. Patient came to us 1 week
after the injury complaining of foreign body sensation in finger without any neurovascular symptoms. Only 2 mm of wound with
granulation tissue was present on the proximal phalanx of the middle finger. Ring was cut and removed through the same wound.
Wound healed with full functions of the finger on further follow up. To the best of our knowledge this the first case report
of post traumatic completely embedded ring. 相似文献
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