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131.
Devdatta Suhas Neogi Vivek Trikha Kaushal Kant Mishra Shivanand M. Bandekar Chandra Shekhar Yadav 《Indian Journal of Orthopaedics》2015,49(2):193-198
Background:
Bicondylar tibial plateau fractures are complex injuries and treatment is challenging. Ideal method is still controversial with risk of unsatisfactory results if not treated properly. Many different techniques of internal and external fixation are used. This study compares the clinical results in single locked plating versus dual plating (DP) using two incision approaches. Our hypothesis was that DP leads to less collapse and change in alignment at final followup compared with single plating.Materials and Methods:
61 cases of Type C tibial plateau fractures operated between January 2007 and June 2011 were included in this prospective study. All cases were operated either by single lateral locked plate by anterolateral approach or double plating through double incision. All cases were followed for a minimum of 24 months radiologically and clinically. The statistical analysis was performed using software SPSS 10.0 to analyze the data.Results:
Twenty nine patients in a single lateral locked plate and 32 patients in a double plating group were followed for minimum 2 years. All fractures healed, however there was a significant incidence of malalignment in the single lateral plating group. Though there was a significant increase in soft tissue issues with the double plating group; however, there was only 3.12% incidence of deep infection. There was no significant difference in Hospital for special surgery score at 2 years followup.Conclusion:
Double plating through two incisions resulted in a better limb alignment and joint reduction with an acceptable soft tissue complication rate. 相似文献132.
Daniel K. White Tuhina Neogi David T. Felson Michael LaValley K. Doug Gross Jingbo Niu Michael Nevitt Cora E. Lewis Jim Torner Lisa Fredman 《Arthritis care & research》2012,64(9):1312-1319
Objective
While depressive symptoms and knee pain are independently known to impede daily walking in older adults, it is unknown whether positive affect promotes daily walking. This study investigated this association among adults with knee osteoarthritis (OA) and examined whether knee pain modified this association.Methods
This study is a cross‐sectional analysis of the Multicenter Osteoarthritis Study. We included 1,018 participants (mean ± SD age 63.1 ± 7.8 years, 60% women) who had radiographic knee OA and had worn a StepWatch monitor to record their number of steps per day. High and low positive affect and depressive symptoms were based on the Center for Epidemiologic Studies Depression Scale. Knee pain was categorized as present in respondents who reported pain on most days at both a clinic visit and a telephone screening.Results
Compared to respondents with low positive affect (27% of all respondents), those with high positive affect (63%) walked a similar number of steps per day, while those with depressive symptoms (10%) walked less (adjusted β ?32.6 [95% confidence interval (95% CI) ?458.9, 393.8] and ?579.1 [95% CI ?1,274.9, 116.7], respectively). There was a statistically significant interaction of positive affect by knee pain (P = 0.0045). Among the respondents with knee pain (39%), those with high positive affect walked significantly more steps per day (adjusted β 711.0 [95% CI 55.1, 1,366.9]) than those with low positive affect.Conclusion
High positive affect was associated with more daily walking among adults with painful knee OA. Positive affect may be an important psychological factor to consider for promoting physical activity among people with painful knee OA.133.
134.
Sharon L. Kolasinski Tuhina Neogi Marc C. Hochberg Carol Oatis Gordon Guyatt Joel Block Leigh Callahan Cindy Copenhaver Carole Dodge David Felson Kathleen Gellar William F. Harvey Gillian Hawker Edward Herzig C. Kent Kwoh Amanda E. Nelson Jonathan Samuels Carla Scanzello Daniel White Barton Wise Roy D. Altman Dana DiRenzo Joann Fontanarosa Gina Giradi Mariko Ishimori Devyani Misra Amit Aakash Shah Anna K. Shmagel Louise M. Thoma Marat Turgunbaev Amy S. Turner James Reston 《Arthritis care & research》2020,72(2):149-162
135.
Yongtao Duan Abhishek Dhar Chetan Patel Mehul Khimani Swarnali Neogi Prolay Sharma Nadavala Siva Kumar Rohit L. Vekariya 《RSC advances》2020,10(45):26777
Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal carriers, nanolipid dispersions (liposomes, deformable liposomes, virosomes, ethosomes, and solid lipid nanoparticles) are ideal delivery systems with the advantages of biodegradation and nontoxicity. Among them, nano-structured lipid carriers and solid lipid nanoparticles (SLNs) are dominant, which can be modified to exhibit various advantages, compared to liposomes and polymeric nanoparticles. Nano-structured lipid carriers and SLNs are non-biotoxic since they are biodegradable. Besides, they are highly stable. Their (nano-structured lipid carriers and SLNs) morphology, structural characteristics, ingredients used for preparation, techniques for their production, and characterization using various methods are discussed in this review. Also, although nano-structured lipid carriers and SLNs are based on lipids and surfactants, the effect of these two matrixes to build excipients is also discussed together with their pharmacological significance with novel theranostic approaches, stability and storage.Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. 相似文献
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HIV/AIDS has emerged as a major public health problem since its recognition as an emerging disease a couple of decades ago. While detection of HIV/AIDS cases remains a problem, ascertainment of AIDS deaths has emerged as a bigger challenge and concern. Despite a plethora of literature focusing on the methods to estimate AIDS deaths, none seems to be fulfilling the requirements for universal acceptance. In this paper, we give a systematic review of various methods used by experts to have a reliable estimate of the number of deaths due to AIDS. Initial assessments were derived from morgue based estimates in Africa which showed that AIDS was a leading cause of death. Its impact on demography was noticed in some of the studies conducted wherein age and sex specific mortality rates, standardized mortality ratios, potential years of life lost and decrease in life expectancy were calculated. "Excess mortality factor" as observed in 1980s and 1990s also indicated the approximate number of AIDS deaths. Besides, orphan hood method and verbal autopsy technique too, emerged as reliable means to identify mortality due to AIDS. Some indirect methods like estimation of deaths due to opportunistic infections like tuberculosis could also be a good indicator. The paper reviews the merits and possible biases encountered with each of the methods. 相似文献